Association between the replication capacity and mother-to-child transmission of HIV-1, in antiretroviral drug-naive Malawian women

Susan Eshleman, Yolanda Lie, Donald R. Hoover, Shu Chen, Sarah E. Hudelson, Susan A. Fiscus, Christos J. Petropoulos, Newton Kumwenda, Neil Parkin, Taha E Taha

Research output: Contribution to journalArticle

Abstract

Replication capacity and transmission of human immunodeficiency virus (HIV)-1 in antiretroviral drug-naive Malawian women who had subtype C infection were investigated. Infant children of these women received either 1 dose of nevirapine or 1 dose of nevirapine plus 1 week of daily doses of zidovudine. PhenoSense HIV was used to determine replication capacity in 49 women whose infants were infected with HIV-1 and in 47 women whose infants were uninfected by 6-8 weeks of age. Mean replication capacity was higher in transmitters than in nontransmitters (P = .01). In a multivariate model, higher replication capacity was associated with transmission (odds ratio, 1.45 for each 10% increase in replication capacity [95% confidence interval, 1.11-1.90]; P = .0063), after adjustment for maternal HIV-1 load and other factors.

Original languageEnglish (US)
Pages (from-to)1512-1515
Number of pages4
JournalJournal of Infectious Diseases
Volume193
Issue number11
DOIs
StatePublished - Jun 1 2006

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HIV-1
Mothers
Nevirapine
Pharmaceutical Preparations
Zidovudine
Odds Ratio
HIV
Confidence Intervals
Infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Association between the replication capacity and mother-to-child transmission of HIV-1, in antiretroviral drug-naive Malawian women. / Eshleman, Susan; Lie, Yolanda; Hoover, Donald R.; Chen, Shu; Hudelson, Sarah E.; Fiscus, Susan A.; Petropoulos, Christos J.; Kumwenda, Newton; Parkin, Neil; Taha, Taha E.

In: Journal of Infectious Diseases, Vol. 193, No. 11, 01.06.2006, p. 1512-1515.

Research output: Contribution to journalArticle

Eshleman, S, Lie, Y, Hoover, DR, Chen, S, Hudelson, SE, Fiscus, SA, Petropoulos, CJ, Kumwenda, N, Parkin, N & Taha, TE 2006, 'Association between the replication capacity and mother-to-child transmission of HIV-1, in antiretroviral drug-naive Malawian women', Journal of Infectious Diseases, vol. 193, no. 11, pp. 1512-1515. https://doi.org/10.1086/503810
Eshleman, Susan ; Lie, Yolanda ; Hoover, Donald R. ; Chen, Shu ; Hudelson, Sarah E. ; Fiscus, Susan A. ; Petropoulos, Christos J. ; Kumwenda, Newton ; Parkin, Neil ; Taha, Taha E. / Association between the replication capacity and mother-to-child transmission of HIV-1, in antiretroviral drug-naive Malawian women. In: Journal of Infectious Diseases. 2006 ; Vol. 193, No. 11. pp. 1512-1515.
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