Association between specific plasmids and relapse in typhoid fever

E. Gotuzzo, J. G. Morris, L. Benavente, P. K. Wood, O. Levine, Robert E Black, M. M. Levine

Research output: Contribution to journalArticle

Abstract

We studied isolates from 73 patients hospitalized with typhoid fever in Lima, Peru. Of these 73 patients, 11 (15%) suffered a clinical relapse, with fever and positive blood cultures, within 3 months of their original illness. Using plasmids as epidemiologic markers, we found that three patients who subsequently relapsed were initially infected with more than one strain of Salmonella typhi. There was a highly significant association between relapse and isolation of a strain containing either a 24- or 38-kilobase plasmid at the time of the original infection; however, we were unable to show any evidence of homology between these two plasmids. Our data indicate that infection with multiple strains is not uncommon in this endemic area and suggest that relapse may be partly strain dependent.

Original languageEnglish (US)
Pages (from-to)1779-1781
Number of pages3
JournalJournal of Clinical Microbiology
Volume25
Issue number9
StatePublished - 1987
Externally publishedYes

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Typhoid Fever
Plasmids
Recurrence
Salmonella typhi
Peru
Infection
Fever

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Gotuzzo, E., Morris, J. G., Benavente, L., Wood, P. K., Levine, O., Black, R. E., & Levine, M. M. (1987). Association between specific plasmids and relapse in typhoid fever. Journal of Clinical Microbiology, 25(9), 1779-1781.

Association between specific plasmids and relapse in typhoid fever. / Gotuzzo, E.; Morris, J. G.; Benavente, L.; Wood, P. K.; Levine, O.; Black, Robert E; Levine, M. M.

In: Journal of Clinical Microbiology, Vol. 25, No. 9, 1987, p. 1779-1781.

Research output: Contribution to journalArticle

Gotuzzo, E, Morris, JG, Benavente, L, Wood, PK, Levine, O, Black, RE & Levine, MM 1987, 'Association between specific plasmids and relapse in typhoid fever', Journal of Clinical Microbiology, vol. 25, no. 9, pp. 1779-1781.
Gotuzzo E, Morris JG, Benavente L, Wood PK, Levine O, Black RE et al. Association between specific plasmids and relapse in typhoid fever. Journal of Clinical Microbiology. 1987;25(9):1779-1781.
Gotuzzo, E. ; Morris, J. G. ; Benavente, L. ; Wood, P. K. ; Levine, O. ; Black, Robert E ; Levine, M. M. / Association between specific plasmids and relapse in typhoid fever. In: Journal of Clinical Microbiology. 1987 ; Vol. 25, No. 9. pp. 1779-1781.
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