TY - JOUR
T1 - Association Between Sleep Problems and Perceived Cognitive Dysfunction Over 12 Months in Individuals with Multiple Sclerosis
AU - Hughes, Abbey J.
AU - Turner, Aaron P.
AU - Alschuler, Kevin N.
AU - Atkins, David C.
AU - Beier, Meghan
AU - Amtmann, Dagmar
AU - Ehde, Dawn M.
N1 - Funding Information:
Contents of this article were developed under grants from the Department of Education National Institute on Disability and Rehabilitation Research (grant number H133B080025); and the National Multiple Sclerosis Society (grant number MB0026). Contents of this article were developed under grants from the Department of Education National Institute on Disability and Rehabilitation Research (grant number H133B080025); and the National Multiple Sclerosis Society (grant number MB0026).
Publisher Copyright:
Copyright © Taylor & Francis Group, LLC.
PY - 2018/1/2
Y1 - 2018/1/2
N2 - Sleep problems are highly prevalent among individuals with multiple sclerosis (MS); however, the relationship between sleep problems and cognitive dysfunction is poorly understood in this population. In the present study, 163 individuals with MS and depression, fatigue, or pain completed self-report measures of sleep, cognitive dysfunction, and relevant demographic and clinical characteristics (e.g., disability severity, depressive symptomatology, pain intensity, fatigue impact) at four time points over 12 months. Mixed-effects regression demonstrated that poorer sleep was independently associated with worse perceived cognitive dysfunction (β = –0.05, p =.001), beyond the influence of depressive symptomatology. Fatigue impact was found to partially mediate this relationship. Results suggest that for individuals with MS and depression, fatigue, or pain, self-reported sleep problems are related to perceived cognitive dysfunction, and that fatigue impact accounts for part of this relationship.
AB - Sleep problems are highly prevalent among individuals with multiple sclerosis (MS); however, the relationship between sleep problems and cognitive dysfunction is poorly understood in this population. In the present study, 163 individuals with MS and depression, fatigue, or pain completed self-report measures of sleep, cognitive dysfunction, and relevant demographic and clinical characteristics (e.g., disability severity, depressive symptomatology, pain intensity, fatigue impact) at four time points over 12 months. Mixed-effects regression demonstrated that poorer sleep was independently associated with worse perceived cognitive dysfunction (β = –0.05, p =.001), beyond the influence of depressive symptomatology. Fatigue impact was found to partially mediate this relationship. Results suggest that for individuals with MS and depression, fatigue, or pain, self-reported sleep problems are related to perceived cognitive dysfunction, and that fatigue impact accounts for part of this relationship.
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U2 - 10.1080/15402002.2016.1173553
DO - 10.1080/15402002.2016.1173553
M3 - Article
C2 - 27167969
AN - SCOPUS:84966714099
SN - 1540-2002
VL - 16
SP - 79
EP - 91
JO - Behavioral Sleep Medicine
JF - Behavioral Sleep Medicine
IS - 1
ER -