TY - JOUR
T1 - Association Between Sleep Problems and Perceived Cognitive Dysfunction Over 12 Months in Individuals with Multiple Sclerosis
AU - Hughes, Abbey J.
AU - Turner, Aaron P.
AU - Alschuler, Kevin N.
AU - Atkins, David C.
AU - Beier, Meghan
AU - Amtmann, Dagmar
AU - Ehde, Dawn M.
N1 - Publisher Copyright:
Copyright © Taylor & Francis Group, LLC.
PY - 2018/1/2
Y1 - 2018/1/2
N2 - Sleep problems are highly prevalent among individuals with multiple sclerosis (MS); however, the relationship between sleep problems and cognitive dysfunction is poorly understood in this population. In the present study, 163 individuals with MS and depression, fatigue, or pain completed self-report measures of sleep, cognitive dysfunction, and relevant demographic and clinical characteristics (e.g., disability severity, depressive symptomatology, pain intensity, fatigue impact) at four time points over 12 months. Mixed-effects regression demonstrated that poorer sleep was independently associated with worse perceived cognitive dysfunction (β = –0.05, p =.001), beyond the influence of depressive symptomatology. Fatigue impact was found to partially mediate this relationship. Results suggest that for individuals with MS and depression, fatigue, or pain, self-reported sleep problems are related to perceived cognitive dysfunction, and that fatigue impact accounts for part of this relationship.
AB - Sleep problems are highly prevalent among individuals with multiple sclerosis (MS); however, the relationship between sleep problems and cognitive dysfunction is poorly understood in this population. In the present study, 163 individuals with MS and depression, fatigue, or pain completed self-report measures of sleep, cognitive dysfunction, and relevant demographic and clinical characteristics (e.g., disability severity, depressive symptomatology, pain intensity, fatigue impact) at four time points over 12 months. Mixed-effects regression demonstrated that poorer sleep was independently associated with worse perceived cognitive dysfunction (β = –0.05, p =.001), beyond the influence of depressive symptomatology. Fatigue impact was found to partially mediate this relationship. Results suggest that for individuals with MS and depression, fatigue, or pain, self-reported sleep problems are related to perceived cognitive dysfunction, and that fatigue impact accounts for part of this relationship.
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U2 - 10.1080/15402002.2016.1173553
DO - 10.1080/15402002.2016.1173553
M3 - Article
C2 - 27167969
AN - SCOPUS:84966714099
SN - 1540-2002
VL - 16
SP - 79
EP - 91
JO - Behavioral Sleep Medicine
JF - Behavioral Sleep Medicine
IS - 1
ER -