TY - JOUR
T1 - Association between sex steroid hormones and hematocrit in a nationally representative sample of men
AU - Paller, Channing J.
AU - Shiels, Meredith S.
AU - Rohrmann, Sabine
AU - Menke, Andy
AU - Rifai, Nader
AU - Nelson, William G.
AU - Platz, Elizabeth A.
AU - Dobs, Adrian S.
PY - 2012
Y1 - 2012
N2 - Low or high hematocrit levels are associated with increased morbidity and mortality, mediated via anemia or thromboembolic events, respectively. It is therefore important to identify factors that influence hematocrit. Although androgens are known to stimulate hematopoietic cells, it is unknown whether circulating sex steroid hormones affect hematocrit. The association between serum sex steroid hormone concentrations and hematocrit in men aged ≥20 years was evaluated in a cross-sectional study of 1273 men in the Third National Health and Nutrition Examination Survey (1988-1991). Outcomes were low (<10th percentile), high (>90th percentile), and mean hematocrit. Men with low free testosterone levels had a lower hematocrit than men with normal free testosterone levels (P=.03), although no relationship was found between total testosterone level and hematocrit. The relationship between sex hormone-binding globulin (SHBG) and hematocrit was complex, with both low (P<.001) and high (P=.01) SHBG levels associated with lower hematocrit in men aged ≥20 years and only high (P=.01) SHBG levels in men aged ≥50 years. The odds ratio (OR) of high vs normal hematocrit increased as total estradiol (OR, 2.84; P trend=.04) and free estradiol (OR, 2.23; P trend=.09) levels increased. In this nationally representative study of men, sex steroid hormone levels, particularly low free testosterone and high SHBG levels, were associated with lower hematocrit, and high total and free estradiol levels were associated with high hematocrit. Thus, changes in sex hormone levels with aging may contribute to the increased prevalence of anemia and thromboembolic stroke in men as they age.
AB - Low or high hematocrit levels are associated with increased morbidity and mortality, mediated via anemia or thromboembolic events, respectively. It is therefore important to identify factors that influence hematocrit. Although androgens are known to stimulate hematopoietic cells, it is unknown whether circulating sex steroid hormones affect hematocrit. The association between serum sex steroid hormone concentrations and hematocrit in men aged ≥20 years was evaluated in a cross-sectional study of 1273 men in the Third National Health and Nutrition Examination Survey (1988-1991). Outcomes were low (<10th percentile), high (>90th percentile), and mean hematocrit. Men with low free testosterone levels had a lower hematocrit than men with normal free testosterone levels (P=.03), although no relationship was found between total testosterone level and hematocrit. The relationship between sex hormone-binding globulin (SHBG) and hematocrit was complex, with both low (P<.001) and high (P=.01) SHBG levels associated with lower hematocrit in men aged ≥20 years and only high (P=.01) SHBG levels in men aged ≥50 years. The odds ratio (OR) of high vs normal hematocrit increased as total estradiol (OR, 2.84; P trend=.04) and free estradiol (OR, 2.23; P trend=.09) levels increased. In this nationally representative study of men, sex steroid hormone levels, particularly low free testosterone and high SHBG levels, were associated with lower hematocrit, and high total and free estradiol levels were associated with high hematocrit. Thus, changes in sex hormone levels with aging may contribute to the increased prevalence of anemia and thromboembolic stroke in men as they age.
KW - Estradiol
KW - Nhanes iii
KW - Sex hormone-binding globulin
KW - Testosterone
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U2 - 10.2164/jandrol.111.015651
DO - 10.2164/jandrol.111.015651
M3 - Article
C2 - 22604627
AN - SCOPUS:84874407727
SN - 0196-3635
VL - 33
SP - 1332
EP - 1341
JO - Journal of andrology
JF - Journal of andrology
IS - 6
ER -