TY - JOUR
T1 - Association between sex hormones and adiposity
T2 - Qualitative differences in women and men in the multi-ethnic study of atherosclerosis
AU - Mongraw-Chaffin, Morgana L.
AU - Anderson, Cheryl A.M.
AU - Allison, Matthew A.
AU - Ouyang, Pamela
AU - Szklo, Moyses
AU - Vaidya, Dhananjay
AU - Woodward, Mark
AU - Golden, Sherita Hill
N1 - Publisher Copyright:
Copyright © 2015 by the Endocrine Society.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Context: Sex hormones may influence adipose tissue deposition, possibly contributing to sex disparities in cardiovascular disease risk. Objective: We hypothesized that associations of sex hormone levels with visceral and subcutaneous fat differ by sex. Design, Setting, and Participants: Participants were from the Multi-Ethnic Study of Atherosclerosis with sex hormone levels at baseline and visceral and subcutaneous fat measurements from computed tomography at visit 2 or 3 (n = 1835). Main Outcome Measures: Multivariable linear regression was used to investigate the relationships between sex hormones and adiposity. Testing for interaction by sex, race/ethnicity, and age was conducted. Results: In adjusted models, there was a modest significant positive association between estradiol and visceral fat in both sexes (percent difference in visceral fat for1%difference in hormone [95% confidence interval] inwomen, 5.44 [1.82, 9.09]; and in men, 8.22 [0.61, 16.18]). Higher bioavailable T was significantly associated with higher visceral and subcutaneous fat in women and with the reverse in men (women, 14.38 [10.23, 18.69]; men, -7.69 [-13.06, -1.00]). Higher dehydroepiandrosterone was associated with higher visceral fat in women (7.57 [1.71, 13.88]), but not in men (-2.47 [-8.88, 4.29]). Higher SHBG was associated with significantly lower levels of adiposity in both sexes (women, -24.42 [-28.11, -20.55]; men, -27.39 [-32.97, -21.34]). There was no significant interaction by race/ethnicity or age. Conclusion: Sex hormones are significantly associated with adiposity, and the associations of and rogens differ qualitatively by sex. This heterogeneity may help explain the complexity of the contribution of sex hormones to sex differences in cardiovascular disease.
AB - Context: Sex hormones may influence adipose tissue deposition, possibly contributing to sex disparities in cardiovascular disease risk. Objective: We hypothesized that associations of sex hormone levels with visceral and subcutaneous fat differ by sex. Design, Setting, and Participants: Participants were from the Multi-Ethnic Study of Atherosclerosis with sex hormone levels at baseline and visceral and subcutaneous fat measurements from computed tomography at visit 2 or 3 (n = 1835). Main Outcome Measures: Multivariable linear regression was used to investigate the relationships between sex hormones and adiposity. Testing for interaction by sex, race/ethnicity, and age was conducted. Results: In adjusted models, there was a modest significant positive association between estradiol and visceral fat in both sexes (percent difference in visceral fat for1%difference in hormone [95% confidence interval] inwomen, 5.44 [1.82, 9.09]; and in men, 8.22 [0.61, 16.18]). Higher bioavailable T was significantly associated with higher visceral and subcutaneous fat in women and with the reverse in men (women, 14.38 [10.23, 18.69]; men, -7.69 [-13.06, -1.00]). Higher dehydroepiandrosterone was associated with higher visceral fat in women (7.57 [1.71, 13.88]), but not in men (-2.47 [-8.88, 4.29]). Higher SHBG was associated with significantly lower levels of adiposity in both sexes (women, -24.42 [-28.11, -20.55]; men, -27.39 [-32.97, -21.34]). There was no significant interaction by race/ethnicity or age. Conclusion: Sex hormones are significantly associated with adiposity, and the associations of and rogens differ qualitatively by sex. This heterogeneity may help explain the complexity of the contribution of sex hormones to sex differences in cardiovascular disease.
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U2 - 10.1210/jc.2014-2934
DO - 10.1210/jc.2014-2934
M3 - Article
C2 - 25636047
AN - SCOPUS:84927636503
SN - 0021-972X
VL - 100
SP - E596-E600
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 4
ER -