Association between semen exposure and incident bacterial vaginosis

Maria F. Gallo, Lee Warner, Caroline C. King, Jack D. Sobel, Robert S. Klein, Susan Cu-Uvin, Anne M. Rompalo, Denise J. Jamieson

Research output: Contribution to journalArticle

Abstract

Objective. To identify correlates of incident bacterial vaginosis (BV) diagnosed with Nugent scoring among high-risk women. Study Design. We conducted both cohort and case-crossover analyses, stratified by HIV infection status, based on 871 HIV-infected and 439 HIV-uninfected participants in the HIV Epidemiology Research Study, conducted in 4 US sites in 1993-2000. Results. BV incidence was 21 and 19 among HIV-infected and -uninfected women, respectively. Fewer correlates of BV were found with case-crossover than with cohort design. Reporting frequent coitus (regardless of consistency of condom use) was correlated with BV in cohort analyses but not in case-crossover analyses. The sole correlate of BV in both types of analyses was the detection of spermatozoa on Gram stain, which is a marker of semen exposure. Conclusion. The inconsistent association between condom use and BV in prior studies could be from reporting bias. We found evidence of a relationship between semen exposure and incident BV.

Original languageEnglish (US)
Article number842652
JournalInfectious Diseases in Obstetrics and Gynecology
Volume2011
DOIs
StatePublished - Dec 1 2011

ASJC Scopus subject areas

  • Dermatology
  • Obstetrics and Gynecology
  • Infectious Diseases

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    Gallo, M. F., Warner, L., King, C. C., Sobel, J. D., Klein, R. S., Cu-Uvin, S., Rompalo, A. M., & Jamieson, D. J. (2011). Association between semen exposure and incident bacterial vaginosis. Infectious Diseases in Obstetrics and Gynecology, 2011, [842652]. https://doi.org/10.1155/2011/842652