Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder

Thomas W. Mühleisen, Manuel Mattheisen, Jana Strohmaier, Franziska Degenhardt, Lutz Priebe, C. Christoph Schultz, René Breuer, Sandra Meier, Per Hoffmann, Fernando Rivandeneira, Albert Hofman, André G. Uitterlinden, Susanne Moebus, Christian Gieger, Rebecca Emeny, Karl Heinz Ladwig, H. Erich Wichmann, Markus Schwarz, Jutta Kammerer-Ciernioch, Ralf G M SchlösserIgor Nenadic, Heinrich Sauer, Rainald Mössner, Wolfgang Maier, Dan Rujescu, Christoph Lange, Roel A. Ophoff, Thomas G. Schulze, Marcella Rietschel, Markus M. Nöthen, Sven Cichon

Research output: Contribution to journalArticlepeer-review


A recent study found genome-wide significant association between common variation in the gene neurocan (NCAN, rs1064395) and bipolar disorder (BD). In view of accumulating evidence that BD and schizophrenia partly share genetic risk factors, we tested this single-nucleotide polymorphism for association with schizophrenia in three independent patient-control samples of European ancestry, totaling 5061 patients and 9655 controls. The rs1064395 A-allele, which confers risk for BD, was significantly over-represented in schizophrenia patients compared to controls (p=2.28×10 -3; odds ratio=1.11). Follow-up in non-overlapping samples from the Schizophrenia Psychiatric GWAS Consortium (5537 patients, 8043 controls) provided further support for our finding (p=0.0239, odds ratio=1.07). Our data suggest that genetic variation in NCAN is a common risk factor for BD and schizophrenia.

Original languageEnglish (US)
Pages (from-to)69-73
Number of pages5
JournalSchizophrenia Research
Issue number1
StatePublished - Jun 2012
Externally publishedYes


  • Association
  • Cortex
  • Genetic overlap
  • Hippocampus
  • Manic depression
  • Psychotic disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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