Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder

Thomas W. Mühleisen; Manuel Mattheisen; Jana Strohmaier; Franziska Degenhardt; Lutz Priebe; C. Christoph Schultz; René Breuer; Sandra Meier; Per Hoffmann; Fernando Rivandeneira; Albert Hofman; André G. Uitterlinden; Susanne Moebus; Christian Gieger; Rebecca Emeny; Karl Heinz Ladwig; H. Erich Wichmann; Markus Schwarz; Jutta Kammerer-Ciernioch; Ralf G M Schlösser; Igor Nenadic; Heinrich Sauer; Rainald Mössner; Wolfgang Maier; Dan Rujescu; Christoph Lange; Roel A. Ophoff; Thomas G. Schulze; Marcella Rietschel; Markus M. Nöthen; Sven Cichon

doi:10.1016/j.schres.2012.03.007

Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder

Thomas W. Mühleisen, Manuel Mattheisen, Jana Strohmaier, Franziska Degenhardt, Lutz Priebe, C. Christoph Schultz, René Breuer, Sandra Meier, Per Hoffmann, Fernando Rivandeneira, Albert Hofman, André G. Uitterlinden, Susanne Moebus, Christian Gieger, Rebecca Emeny, Karl Heinz Ladwig, H. Erich Wichmann, Markus Schwarz, Jutta Kammerer-Ciernioch, Ralf G M SchlösserIgor Nenadic, Heinrich Sauer, Rainald Mössner, Wolfgang Maier, Dan Rujescu, Christoph Lange, Roel A. Ophoff, Thomas G. Schulze, Marcella Rietschel, Markus M. Nöthen, Sven Cichon

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

A recent study found genome-wide significant association between common variation in the gene neurocan (NCAN, rs1064395) and bipolar disorder (BD). In view of accumulating evidence that BD and schizophrenia partly share genetic risk factors, we tested this single-nucleotide polymorphism for association with schizophrenia in three independent patient-control samples of European ancestry, totaling 5061 patients and 9655 controls. The rs1064395 A-allele, which confers risk for BD, was significantly over-represented in schizophrenia patients compared to controls (p=2.28×10 ^-3; odds ratio=1.11). Follow-up in non-overlapping samples from the Schizophrenia Psychiatric GWAS Consortium (5537 patients, 8043 controls) provided further support for our finding (p=0.0239, odds ratio=1.07). Our data suggest that genetic variation in NCAN is a common risk factor for BD and schizophrenia.

Original language	English (US)
Pages (from-to)	69-73
Number of pages	5
Journal	Schizophrenia Research
Volume	138
Issue number	1
DOIs	https://doi.org/10.1016/j.schres.2012.03.007
State	Published - Jun 2012
Externally published	Yes

Keywords

Association
Cortex
Genetic overlap
Hippocampus
Manic depression
Psychotic disorder

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2012.03.007

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Mühleisen, T. W., Mattheisen, M., Strohmaier, J., Degenhardt, F., Priebe, L., Schultz, C. C., Breuer, R., Meier, S., Hoffmann, P., Rivandeneira, F., Hofman, A., Uitterlinden, A. G., Moebus, S., Gieger, C., Emeny, R., Ladwig, K. H., Wichmann, H. E., Schwarz, M., Kammerer-Ciernioch, J., ... Cichon, S. (2012). Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder. Schizophrenia Research, 138(1), 69-73. https://doi.org/10.1016/j.schres.2012.03.007

Mühleisen, TW, Mattheisen, M, Strohmaier, J, Degenhardt, F, Priebe, L, Schultz, CC, Breuer, R, Meier, S, Hoffmann, P, Rivandeneira, F, Hofman, A, Uitterlinden, AG, Moebus, S, Gieger, C, Emeny, R, Ladwig, KH, Wichmann, HE, Schwarz, M, Kammerer-Ciernioch, J, Schlösser, RGM, Nenadic, I, Sauer, H, Mössner, R, Maier, W, Rujescu, D, Lange, C, Ophoff, RA, Schulze, TG, Rietschel, M, Nöthen, MM & Cichon, S 2012, 'Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder', Schizophrenia Research, vol. 138, no. 1, pp. 69-73. https://doi.org/10.1016/j.schres.2012.03.007

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title = "Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder",

abstract = "A recent study found genome-wide significant association between common variation in the gene neurocan (NCAN, rs1064395) and bipolar disorder (BD). In view of accumulating evidence that BD and schizophrenia partly share genetic risk factors, we tested this single-nucleotide polymorphism for association with schizophrenia in three independent patient-control samples of European ancestry, totaling 5061 patients and 9655 controls. The rs1064395 A-allele, which confers risk for BD, was significantly over-represented in schizophrenia patients compared to controls (p=2.28×10 -3; odds ratio=1.11). Follow-up in non-overlapping samples from the Schizophrenia Psychiatric GWAS Consortium (5537 patients, 8043 controls) provided further support for our finding (p=0.0239, odds ratio=1.07). Our data suggest that genetic variation in NCAN is a common risk factor for BD and schizophrenia.",

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AU - Priebe, Lutz

AU - Schultz, C. Christoph

AU - Breuer, René

AU - Meier, Sandra

AU - Hoffmann, Per

AU - Rivandeneira, Fernando

AU - Hofman, Albert

AU - Uitterlinden, André G.

AU - Moebus, Susanne

AU - Gieger, Christian

AU - Emeny, Rebecca

AU - Ladwig, Karl Heinz

AU - Wichmann, H. Erich

AU - Schwarz, Markus

AU - Kammerer-Ciernioch, Jutta

AU - Schlösser, Ralf G M

AU - Nenadic, Igor

AU - Sauer, Heinrich

AU - Mössner, Rainald

AU - Maier, Wolfgang

AU - Rujescu, Dan

AU - Lange, Christoph

AU - Ophoff, Roel A.

AU - Schulze, Thomas G.

AU - Rietschel, Marcella

AU - Nöthen, Markus M.

AU - Cichon, Sven

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Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder

Abstract

Keywords

ASJC Scopus subject areas

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