Association between saccular function and gait speed: Data from the Baltimore Longitudinal study of aging

Andrew J. Layman, Carol Li, Eleanor Simonsick, Luigi Ferrucci, John P. Carey, Yuri Agrawal

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To investigate whether otolith function (saccular and utricular) is associated with walking performance. STUDY DESIGN: Cross-sectional analysis of observational data collected in the Baltimore Longitudinal Study of Aging. SETTING: National Institute on Aging Intramural Research Program Clinical Research Unit at Harbor Hospital, Baltimore, Maryland. PATIENTS: Community-dwelling participants. INTERVENTION(S): Cervical and ocular vestibular evoked myogenic potentials (VEMPs) were used to assess saccular and utricular function, respectively. MAIN OUTCOME MEASURE(S): Cervical and ocular VEMP latency and amplitude responses and usual, rapid, and narrow (20 cm) gait speed assessed over a 6-m course. RESULTS: In 314 participants (mean age, 73.1 yr; range, 26-96 yr), cervical VEMP amplitude mediated the association between age and gait speed - particularly narrow walk speed - in both men and women. Cervical VEMP latency had an independent association with gait speed in age-, height-, and weight-adjusted analyses, although the direction of the association differed by sex. Greater cervical VEMP latency was associated with slower usual, rapid, and narrow gait speed in women but faster rapid gait speed in men. Neither the amplitude nor latency of ocular VEMP was associated with gait speed in men or women. CONCLUSION: These findings suggest that age-related slowing of gait speed is in part mediated by the decreased magnitude of saccular response associated with age. The sex-related differential association between saccular response latency and gait speed requires further study.

Original languageEnglish (US)
Pages (from-to)260-266
Number of pages7
JournalOtology and Neurotology
Volume36
Issue number2
DOIs
StatePublished - Feb 2 2015

Keywords

  • Aging
  • Gait
  • Vestibular dysfunction
  • Vestibular evoked myogenic potentials

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Sensory Systems
  • Clinical Neurology

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