Abstract
Background: The myocardial contraction fraction (MCF: stroke volume to myocardial volume) is a volumetric measure of left ventricular myocardial shortening. We examined the relationship of MCF, measured by cardiac magnetic resonance imaging (cMRI), to incident cardiovascular (CV) events within the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: Participants (n = 5000, aged 45–84 years) underwent cMRI. Primary outcome: CVD events (myocardial infarction, resuscitated cardiac arrest, stroke, coronary heart disease: CHD death, and stroke death). Secondary outcomes: CHD and heart failure (HF) events. Cox proportional hazards regression was used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) for outcomes. Results: There were 299 incident CVD, 188 CHD, and 151 HF events over 10.2 years. The lowest MCF quartile was associated with an increased risk for incident CVD [HR 2.42, CI: 1.58–3.72], CHD [HR 2.32, CI: 1.36–3.96] and HF events [HR 1.99, CI: 1.15–3.44]. In a model adjusted for demographics, CV risk factors, antihypertensive and lipid-lowering medication use, each standard deviation decrease in MCF was associated with incident CVD [HR 1.42, CI: 1.23–1.64], CHD [HR 1.40, CI: 1.17–1.67] and HF [HR 1.58, CI: 1.30–1.94]. In a subgroup analysis of participants with preserved ejection fraction and without left ventricular hypertrophy, the lowest MCF quartile and each standard deviation decrease in MCF was also associated with an increased risk for incident CVD in fully-adjusted analyses. Conclusions: MCF is a novel measure that can be measured using cMRI. In this multi-ethnic cohort, MCF is a measure that can be used to predict incident CVD events.
| Original language | English (US) |
|---|---|
| Journal | International Journal of Cardiology |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Cardiovascular disease
- Epidemiology
- Myocardial contraction fraction
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Association between reduced myocardial contraction fraction and cardiovascular disease outcomes : The Multi-Ethnic Study of Atherosclerosis. / Abdalla, Marwah; Akwo, Elvis A.; Bluemke, David A.; Lima, Joao; Shimbo, Daichi; Maurer, Mathew S.; Bertoni, Alain G.
In: International Journal of Cardiology, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between reduced myocardial contraction fraction and cardiovascular disease outcomes
T2 - The Multi-Ethnic Study of Atherosclerosis
AU - Abdalla, Marwah
AU - Akwo, Elvis A.
AU - Bluemke, David A.
AU - Lima, Joao
AU - Shimbo, Daichi
AU - Maurer, Mathew S.
AU - Bertoni, Alain G.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: The myocardial contraction fraction (MCF: stroke volume to myocardial volume) is a volumetric measure of left ventricular myocardial shortening. We examined the relationship of MCF, measured by cardiac magnetic resonance imaging (cMRI), to incident cardiovascular (CV) events within the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: Participants (n = 5000, aged 45–84 years) underwent cMRI. Primary outcome: CVD events (myocardial infarction, resuscitated cardiac arrest, stroke, coronary heart disease: CHD death, and stroke death). Secondary outcomes: CHD and heart failure (HF) events. Cox proportional hazards regression was used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) for outcomes. Results: There were 299 incident CVD, 188 CHD, and 151 HF events over 10.2 years. The lowest MCF quartile was associated with an increased risk for incident CVD [HR 2.42, CI: 1.58–3.72], CHD [HR 2.32, CI: 1.36–3.96] and HF events [HR 1.99, CI: 1.15–3.44]. In a model adjusted for demographics, CV risk factors, antihypertensive and lipid-lowering medication use, each standard deviation decrease in MCF was associated with incident CVD [HR 1.42, CI: 1.23–1.64], CHD [HR 1.40, CI: 1.17–1.67] and HF [HR 1.58, CI: 1.30–1.94]. In a subgroup analysis of participants with preserved ejection fraction and without left ventricular hypertrophy, the lowest MCF quartile and each standard deviation decrease in MCF was also associated with an increased risk for incident CVD in fully-adjusted analyses. Conclusions: MCF is a novel measure that can be measured using cMRI. In this multi-ethnic cohort, MCF is a measure that can be used to predict incident CVD events.
AB - Background: The myocardial contraction fraction (MCF: stroke volume to myocardial volume) is a volumetric measure of left ventricular myocardial shortening. We examined the relationship of MCF, measured by cardiac magnetic resonance imaging (cMRI), to incident cardiovascular (CV) events within the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: Participants (n = 5000, aged 45–84 years) underwent cMRI. Primary outcome: CVD events (myocardial infarction, resuscitated cardiac arrest, stroke, coronary heart disease: CHD death, and stroke death). Secondary outcomes: CHD and heart failure (HF) events. Cox proportional hazards regression was used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) for outcomes. Results: There were 299 incident CVD, 188 CHD, and 151 HF events over 10.2 years. The lowest MCF quartile was associated with an increased risk for incident CVD [HR 2.42, CI: 1.58–3.72], CHD [HR 2.32, CI: 1.36–3.96] and HF events [HR 1.99, CI: 1.15–3.44]. In a model adjusted for demographics, CV risk factors, antihypertensive and lipid-lowering medication use, each standard deviation decrease in MCF was associated with incident CVD [HR 1.42, CI: 1.23–1.64], CHD [HR 1.40, CI: 1.17–1.67] and HF [HR 1.58, CI: 1.30–1.94]. In a subgroup analysis of participants with preserved ejection fraction and without left ventricular hypertrophy, the lowest MCF quartile and each standard deviation decrease in MCF was also associated with an increased risk for incident CVD in fully-adjusted analyses. Conclusions: MCF is a novel measure that can be measured using cMRI. In this multi-ethnic cohort, MCF is a measure that can be used to predict incident CVD events.
KW - Cardiovascular disease
KW - Epidemiology
KW - Myocardial contraction fraction
UR - http://www.scopus.com/inward/record.url?scp=85069165922&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069165922&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2019.07.040
DO - 10.1016/j.ijcard.2019.07.040
M3 - Article
C2 - 31327521
AN - SCOPUS:85069165922
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -