Association between prenatal exposure to methylmercury and visuospatial ability at 10.7 years in the seychelles child development study

Philip W. Davidson, Jean-Sloane-Reeves, Gary J. Myers, Ole Nørby Hansen, Li Shan Huang, Leslie A. Georger, Christopher Cox, Sally W. Thurston, Conrad F. Shamlaye, Thomas W. Clarkson

Research output: Contribution to journalArticle

Abstract

The Seychelles Child Development Study was designed to test the hypothesis that prenatal exposure to MeHg from maternal consumption of a diet high in fish is detrimental to child neurodevelopment. To date, no consistent pattern of adverse associations between prenatal exposure and children's development has appeared. In a comprehensive review of developmental studies involving MeHg, a panel of experts recommended a more consistent use of the same endpoints across studies to facilitate comparisons. Both the SCDS and the Faeroe Islands studies administered the Bender Visual Motor Gestalt Test. However, the method of test administration and scoring used was different. We repeated the test on the SCDS Main Study children (mean age 10.7 years) using the same testing and scoring procedure reported by the Faeroe studies to obtain Copying Task and Reproduction Task scores. We found no association between prenatal MeHg exposure and Copying Task scores which was reported from the Faeroese study. However, our analysis did show a significant adverse association between MeHg and Reproduction Task scores with all the data (p = 0.04), but not when the single outlier was removed (p = 0.07). In a population whose exposure to MeHg is from fish consumption, we continue to find no consistent adverse association between MeHg and visual motor coordination.

Original languageEnglish (US)
Pages (from-to)453-459
Number of pages7
JournalNeuroToxicology
Volume29
Issue number3
DOIs
StatePublished - May 2008

Fingerprint

Seychelles
Copying
Aptitude
Child Development
Fish
Reproduction
Fishes
Bender-Gestalt Test
Psychomotor Performance
Denmark
Nutrition
Mothers
Diet
Testing
Population

Keywords

  • Methylmercury
  • Prenatal exposure
  • Visual motor development

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Toxicology

Cite this

Davidson, P. W., Jean-Sloane-Reeves, Myers, G. J., Hansen, O. N., Huang, L. S., Georger, L. A., ... Clarkson, T. W. (2008). Association between prenatal exposure to methylmercury and visuospatial ability at 10.7 years in the seychelles child development study. NeuroToxicology, 29(3), 453-459. https://doi.org/10.1016/j.neuro.2008.02.009

Association between prenatal exposure to methylmercury and visuospatial ability at 10.7 years in the seychelles child development study. / Davidson, Philip W.; Jean-Sloane-Reeves; Myers, Gary J.; Hansen, Ole Nørby; Huang, Li Shan; Georger, Leslie A.; Cox, Christopher; Thurston, Sally W.; Shamlaye, Conrad F.; Clarkson, Thomas W.

In: NeuroToxicology, Vol. 29, No. 3, 05.2008, p. 453-459.

Research output: Contribution to journalArticle

Davidson, PW, Jean-Sloane-Reeves, Myers, GJ, Hansen, ON, Huang, LS, Georger, LA, Cox, C, Thurston, SW, Shamlaye, CF & Clarkson, TW 2008, 'Association between prenatal exposure to methylmercury and visuospatial ability at 10.7 years in the seychelles child development study', NeuroToxicology, vol. 29, no. 3, pp. 453-459. https://doi.org/10.1016/j.neuro.2008.02.009
Davidson, Philip W. ; Jean-Sloane-Reeves ; Myers, Gary J. ; Hansen, Ole Nørby ; Huang, Li Shan ; Georger, Leslie A. ; Cox, Christopher ; Thurston, Sally W. ; Shamlaye, Conrad F. ; Clarkson, Thomas W. / Association between prenatal exposure to methylmercury and visuospatial ability at 10.7 years in the seychelles child development study. In: NeuroToxicology. 2008 ; Vol. 29, No. 3. pp. 453-459.
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abstract = "The Seychelles Child Development Study was designed to test the hypothesis that prenatal exposure to MeHg from maternal consumption of a diet high in fish is detrimental to child neurodevelopment. To date, no consistent pattern of adverse associations between prenatal exposure and children's development has appeared. In a comprehensive review of developmental studies involving MeHg, a panel of experts recommended a more consistent use of the same endpoints across studies to facilitate comparisons. Both the SCDS and the Faeroe Islands studies administered the Bender Visual Motor Gestalt Test. However, the method of test administration and scoring used was different. We repeated the test on the SCDS Main Study children (mean age 10.7 years) using the same testing and scoring procedure reported by the Faeroe studies to obtain Copying Task and Reproduction Task scores. We found no association between prenatal MeHg exposure and Copying Task scores which was reported from the Faeroese study. However, our analysis did show a significant adverse association between MeHg and Reproduction Task scores with all the data (p = 0.04), but not when the single outlier was removed (p = 0.07). In a population whose exposure to MeHg is from fish consumption, we continue to find no consistent adverse association between MeHg and visual motor coordination.",
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