Association between polymorphisms in cell cycle genes and advanced prostate carcinoma

Adam S. Kibel, Carol H. Jin, Aleksandra Klim, Jason Luly, Kimberly A. Roehl, William S. Wu, Brian K. Suarez

Research output: Contribution to journalArticle

Abstract

BACKGROUND. Single nucleotide polymorphisms (SNPs) have been associated with a variety of malignancies including prostate carcinoma (PCa). Since a high percentage of PCa patients have low risk disease, of particular interest is not whether SNPs are associated with localized PCa, but whether they are associated with aggressive, potentially lethal disease. Herein, we explored the role of SNPs in cell cycle genes to determine if they were associated with advanced PCa. METHODS. Nine previously implicated SNPs in six cell cycle genes were evaluated in a European-American cohort of 186 patients with advanced PCa and 222 cancer-free controls. All patients received hormone ablation and had either a PSA >50 ng/ml or documented metastatic disease. Controls were all 75 years of age or older, had a negative DRE and had a PSA

Original languageEnglish (US)
Pages (from-to)1179-1186
Number of pages8
JournalProstate
Volume68
Issue number11
DOIs
StatePublished - Aug 2008
Externally publishedYes

Fingerprint

cdc Genes
Prostate
Single Nucleotide Polymorphism
Carcinoma
Neoplasms
Hormones

Keywords

  • Cancer susceptibility
  • Cell cycle
  • Metastatic disease
  • Prostate carcinoma
  • Risk assessment

ASJC Scopus subject areas

  • Urology

Cite this

Kibel, A. S., Jin, C. H., Klim, A., Luly, J., Roehl, K. A., Wu, W. S., & Suarez, B. K. (2008). Association between polymorphisms in cell cycle genes and advanced prostate carcinoma. Prostate, 68(11), 1179-1186. https://doi.org/10.1002/pros.20784

Association between polymorphisms in cell cycle genes and advanced prostate carcinoma. / Kibel, Adam S.; Jin, Carol H.; Klim, Aleksandra; Luly, Jason; Roehl, Kimberly A.; Wu, William S.; Suarez, Brian K.

In: Prostate, Vol. 68, No. 11, 08.2008, p. 1179-1186.

Research output: Contribution to journalArticle

Kibel, AS, Jin, CH, Klim, A, Luly, J, Roehl, KA, Wu, WS & Suarez, BK 2008, 'Association between polymorphisms in cell cycle genes and advanced prostate carcinoma', Prostate, vol. 68, no. 11, pp. 1179-1186. https://doi.org/10.1002/pros.20784
Kibel AS, Jin CH, Klim A, Luly J, Roehl KA, Wu WS et al. Association between polymorphisms in cell cycle genes and advanced prostate carcinoma. Prostate. 2008 Aug;68(11):1179-1186. https://doi.org/10.1002/pros.20784
Kibel, Adam S. ; Jin, Carol H. ; Klim, Aleksandra ; Luly, Jason ; Roehl, Kimberly A. ; Wu, William S. ; Suarez, Brian K. / Association between polymorphisms in cell cycle genes and advanced prostate carcinoma. In: Prostate. 2008 ; Vol. 68, No. 11. pp. 1179-1186.
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