Association between physical activity, physical performance, and inflammatory biomarkers in an elderly population: The InCHIANTI study

Roberto Elosua, Benedetta Bartali, Jose M. Ordovas, Anna M. Corsi, Fulvio Lauretani, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

Background. Our aim was to determine the association between physical activity and physical performance, and inflammatory biomarkers in elderly persons. Methods. One thousand four persons aged 65 years or more, participants in a cross-sectional population-based study, were included. Interviewers collected information on self-reported physical activity during the previous year. Moreover, 841 participants performed a 400-meter walking test to assess physical performance. Plasma concentrations of inflammatory biomarkers were determined. Results. Compared to sedentary men, men practicing light and moderate-high physical activity had a significantly lower erythrocyte sedimentation rate (-0.33 and -0.40 mm/h; p = .023 and p = .006, respectively), fibrinogen level (-43 and -39 mg/dL; p = .001 and p = .004, respectively), and logarithm of C-reactive protein (CRP) (-0.43 and -0.73 mg/L; p = .025 and p <.001, respectively), whereas only those men practicing moderate-high physical activity had a significantly lower uric acid level (-0.57 mg/dL; p = .023), log(interleukin 6) levels (-0.33 pg/mL; p = .014), and log(tumor necrosis factor-α) (-0.31 pg/mL; p = .030). In women, those practicing light and moderate-high physical activity had significantly lower uric acid (-0.45 and -0.34 mg/dL; p = .001 and p = .039, respectively) and log(interleukin 6) levels (-0.18 and -0.30 pg/mL; p = .043 and p = .004, respectively); only those women practicing moderate-high physical activity had significantly lower log(CRP) (-0.31 mg/L; p = .020). In women, when the analysis was adjusted for body mass index, the association between physical activity and CRP was no longer significant. Similar findings were observed when we carried these analyses according to physical performance. Conclusions. Current physical activity practice and performance are associated with inflammatory biomarkers. A significant beneficial association is already observed with light physical activity practice and intermediate performance.

Original languageEnglish (US)
Pages (from-to)760-767
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume60
Issue number6
StatePublished - Jun 2005
Externally publishedYes

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Biomarkers
Exercise
Population
C-Reactive Protein
Uric Acid
Light
Interleukin-6
Blood Sedimentation
Fibrinogen
Walking
Body Mass Index
Tumor Necrosis Factor-alpha
Interviews

ASJC Scopus subject areas

  • Aging

Cite this

Association between physical activity, physical performance, and inflammatory biomarkers in an elderly population : The InCHIANTI study. / Elosua, Roberto; Bartali, Benedetta; Ordovas, Jose M.; Corsi, Anna M.; Lauretani, Fulvio; Ferrucci, Luigi.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 60, No. 6, 06.2005, p. 760-767.

Research output: Contribution to journalArticle

Elosua, Roberto ; Bartali, Benedetta ; Ordovas, Jose M. ; Corsi, Anna M. ; Lauretani, Fulvio ; Ferrucci, Luigi. / Association between physical activity, physical performance, and inflammatory biomarkers in an elderly population : The InCHIANTI study. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2005 ; Vol. 60, No. 6. pp. 760-767.
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abstract = "Background. Our aim was to determine the association between physical activity and physical performance, and inflammatory biomarkers in elderly persons. Methods. One thousand four persons aged 65 years or more, participants in a cross-sectional population-based study, were included. Interviewers collected information on self-reported physical activity during the previous year. Moreover, 841 participants performed a 400-meter walking test to assess physical performance. Plasma concentrations of inflammatory biomarkers were determined. Results. Compared to sedentary men, men practicing light and moderate-high physical activity had a significantly lower erythrocyte sedimentation rate (-0.33 and -0.40 mm/h; p = .023 and p = .006, respectively), fibrinogen level (-43 and -39 mg/dL; p = .001 and p = .004, respectively), and logarithm of C-reactive protein (CRP) (-0.43 and -0.73 mg/L; p = .025 and p <.001, respectively), whereas only those men practicing moderate-high physical activity had a significantly lower uric acid level (-0.57 mg/dL; p = .023), log(interleukin 6) levels (-0.33 pg/mL; p = .014), and log(tumor necrosis factor-α) (-0.31 pg/mL; p = .030). In women, those practicing light and moderate-high physical activity had significantly lower uric acid (-0.45 and -0.34 mg/dL; p = .001 and p = .039, respectively) and log(interleukin 6) levels (-0.18 and -0.30 pg/mL; p = .043 and p = .004, respectively); only those women practicing moderate-high physical activity had significantly lower log(CRP) (-0.31 mg/L; p = .020). In women, when the analysis was adjusted for body mass index, the association between physical activity and CRP was no longer significant. Similar findings were observed when we carried these analyses according to physical performance. Conclusions. Current physical activity practice and performance are associated with inflammatory biomarkers. A significant beneficial association is already observed with light physical activity practice and intermediate performance.",
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T1 - Association between physical activity, physical performance, and inflammatory biomarkers in an elderly population

T2 - The InCHIANTI study

AU - Elosua, Roberto

AU - Bartali, Benedetta

AU - Ordovas, Jose M.

AU - Corsi, Anna M.

AU - Lauretani, Fulvio

AU - Ferrucci, Luigi

PY - 2005/6

Y1 - 2005/6

N2 - Background. Our aim was to determine the association between physical activity and physical performance, and inflammatory biomarkers in elderly persons. Methods. One thousand four persons aged 65 years or more, participants in a cross-sectional population-based study, were included. Interviewers collected information on self-reported physical activity during the previous year. Moreover, 841 participants performed a 400-meter walking test to assess physical performance. Plasma concentrations of inflammatory biomarkers were determined. Results. Compared to sedentary men, men practicing light and moderate-high physical activity had a significantly lower erythrocyte sedimentation rate (-0.33 and -0.40 mm/h; p = .023 and p = .006, respectively), fibrinogen level (-43 and -39 mg/dL; p = .001 and p = .004, respectively), and logarithm of C-reactive protein (CRP) (-0.43 and -0.73 mg/L; p = .025 and p <.001, respectively), whereas only those men practicing moderate-high physical activity had a significantly lower uric acid level (-0.57 mg/dL; p = .023), log(interleukin 6) levels (-0.33 pg/mL; p = .014), and log(tumor necrosis factor-α) (-0.31 pg/mL; p = .030). In women, those practicing light and moderate-high physical activity had significantly lower uric acid (-0.45 and -0.34 mg/dL; p = .001 and p = .039, respectively) and log(interleukin 6) levels (-0.18 and -0.30 pg/mL; p = .043 and p = .004, respectively); only those women practicing moderate-high physical activity had significantly lower log(CRP) (-0.31 mg/L; p = .020). In women, when the analysis was adjusted for body mass index, the association between physical activity and CRP was no longer significant. Similar findings were observed when we carried these analyses according to physical performance. Conclusions. Current physical activity practice and performance are associated with inflammatory biomarkers. A significant beneficial association is already observed with light physical activity practice and intermediate performance.

AB - Background. Our aim was to determine the association between physical activity and physical performance, and inflammatory biomarkers in elderly persons. Methods. One thousand four persons aged 65 years or more, participants in a cross-sectional population-based study, were included. Interviewers collected information on self-reported physical activity during the previous year. Moreover, 841 participants performed a 400-meter walking test to assess physical performance. Plasma concentrations of inflammatory biomarkers were determined. Results. Compared to sedentary men, men practicing light and moderate-high physical activity had a significantly lower erythrocyte sedimentation rate (-0.33 and -0.40 mm/h; p = .023 and p = .006, respectively), fibrinogen level (-43 and -39 mg/dL; p = .001 and p = .004, respectively), and logarithm of C-reactive protein (CRP) (-0.43 and -0.73 mg/L; p = .025 and p <.001, respectively), whereas only those men practicing moderate-high physical activity had a significantly lower uric acid level (-0.57 mg/dL; p = .023), log(interleukin 6) levels (-0.33 pg/mL; p = .014), and log(tumor necrosis factor-α) (-0.31 pg/mL; p = .030). In women, those practicing light and moderate-high physical activity had significantly lower uric acid (-0.45 and -0.34 mg/dL; p = .001 and p = .039, respectively) and log(interleukin 6) levels (-0.18 and -0.30 pg/mL; p = .043 and p = .004, respectively); only those women practicing moderate-high physical activity had significantly lower log(CRP) (-0.31 mg/L; p = .020). In women, when the analysis was adjusted for body mass index, the association between physical activity and CRP was no longer significant. Similar findings were observed when we carried these analyses according to physical performance. Conclusions. Current physical activity practice and performance are associated with inflammatory biomarkers. A significant beneficial association is already observed with light physical activity practice and intermediate performance.

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