TY - JOUR
T1 - Association between obstructive sleep apnea and left ventricular structure by age and gender
T2 - The multi-ethnic study of atherosclerosis
AU - Javaheri, Sogol
AU - Sharma, Ravi K.
AU - Wang, Rui
AU - Weng, Jia
AU - Rosen, Boaz D.
AU - Bluemke, David A.
AU - Lima, Joao A.C.
AU - Redline, Susan
N1 - Funding Information:
This was not an industry supported study. Funding was provided by NIH 5T32HL007901, 1R01HL083075, R01HL098433, R01 HL098433-02S1, 1U34HL105277-01, 1R01HL110068-01A1, and 1R01HL113338-01. Dr. Redline has received research support from Jazz Pharmaceuticals. The other authors have indicated no financial conflicts of interest.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Study Objectives: The presence and severity of obstructive sleep apnea (OSA) are associated with impaired left ventricular (LV) structure and function. Our goal was to quantify the associations between LV systolic function and mass with severity of OSA in an ethnically diverse cohort, assessing variations by age and sex. Methods: We conducted a cross-sectional analysis of data from 1,412 racially/ethnically diverse participants across 6 US communities from the Multi-Ethnic Study of Atherosclerosis who underwent both overnight polysomnography and cardiac magnetic resonance imaging from 2010-2012. We evaluated the association between the obstructive apnea-hypopnea index (AHI) by clinical category (< 5, 5-15, 15-30, 30-50, > 50) and secondary measures of sleep apnea with the outcomes left ventricular (LV) mass adjusted for height, LV mass/volume ratio, and LV ejection fraction. Results: After adjusting for potential confounders and mediators, LV mass was significantly increased with increasing AHI category for subjects age 65 y or younger (β = 1.84 ± 0.47 g/m, P = 0.0001). The association between the AHI and LV mass appeared stronger in whites and Chinese compared to blacks and Hispanics, although interaction terms were not statistically significant. Additionally, while both LV mass and LV mass/volume ratio were significantly associated with hypoxia, ejection fraction was not associated with any OSA severity index. Comparable associations were observed in men and women. Conclusions: Independent of confounders, higher levels of AHI are significantly associated with increased LV mass in both men and women younger than 65 y from a community-based cohort.
AB - Study Objectives: The presence and severity of obstructive sleep apnea (OSA) are associated with impaired left ventricular (LV) structure and function. Our goal was to quantify the associations between LV systolic function and mass with severity of OSA in an ethnically diverse cohort, assessing variations by age and sex. Methods: We conducted a cross-sectional analysis of data from 1,412 racially/ethnically diverse participants across 6 US communities from the Multi-Ethnic Study of Atherosclerosis who underwent both overnight polysomnography and cardiac magnetic resonance imaging from 2010-2012. We evaluated the association between the obstructive apnea-hypopnea index (AHI) by clinical category (< 5, 5-15, 15-30, 30-50, > 50) and secondary measures of sleep apnea with the outcomes left ventricular (LV) mass adjusted for height, LV mass/volume ratio, and LV ejection fraction. Results: After adjusting for potential confounders and mediators, LV mass was significantly increased with increasing AHI category for subjects age 65 y or younger (β = 1.84 ± 0.47 g/m, P = 0.0001). The association between the AHI and LV mass appeared stronger in whites and Chinese compared to blacks and Hispanics, although interaction terms were not statistically significant. Additionally, while both LV mass and LV mass/volume ratio were significantly associated with hypoxia, ejection fraction was not associated with any OSA severity index. Comparable associations were observed in men and women. Conclusions: Independent of confounders, higher levels of AHI are significantly associated with increased LV mass in both men and women younger than 65 y from a community-based cohort.
KW - Cardiac magnetic resonance imaging
KW - Left ventricular mass
KW - Left ventricular mass/volume ratio
KW - Obstructive sleep apnea
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U2 - 10.5665/sleep.5518
DO - 10.5665/sleep.5518
M3 - Article
C2 - 26888453
AN - SCOPUS:84960417165
SN - 0161-8105
VL - 39
SP - 523
EP - 529
JO - Sleep
JF - Sleep
IS - 3
ER -