Association between mild anemia and executive function impairment in community-dwelling older women: The women's health and aging study II

Paulo H.M. Chaves, Michelle C. Carlson, Luigi Ferrucci, Jack M. Guralnik, Richard Semba, Linda P. Fried

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To evaluate the relationship between mild anemia and executive function in community-dwelling older women. DESIGN: Cross-sectional. SETTING: Community-based. PARTICIPANTS: High-functioning subjects participating in the baseline assessment of the Women's Health and Aging Study (WHAS) II, Baltimore, Maryland, 1994 to 1996. WHAS II eligibility criteria included aged 70 to 80, a Mini-Mental State Examination score of 24 or greater, and absence of advanced disability (difficulty in no more than 1 domain of physical function). Included in this study were 364 subjects with a hemoglobin concentration 10 g/dL or greater and known executive function status. MEASUREMENTS: Trail Making Test (TMT) Parts B and A. Tertiles of time to complete each test were used to define best (bottom), intermediate, and worst (top) performance. Tertiles of the difference TMT-B minus TMT-A were calculated. Anemia defined as hemoglobin concentration less than 12 g/dL. RESULTS: The percentage of subjects in the worst TMT-B, TMT-A, and TMT-B minus TMT-A performance tertile was highest for those with anemia. Prevalent anemia substantially increased the likelihood of performing worst (as opposed to best) on the TMT-B (odds ratio (OR)=5.2, 95% confidence interval (CI)=1.3-20.5), TMT-A (OR=4.8, 95% CI=1.5-15.6), and TMT-B minus TMT-A (OR= 4.2, 95% CI=1.0-17.2), even after controlling for age, education, race, prevalent diseases, and relevant physiological and functional parameters. CONCLUSION: This study provides preliminary evidence in support of the hypothesis that mild anemia might be an independent risk factor for executive function impairment in community-dwelling older adults. Whether such an association is causal or noncausal remains to be determined.

Original languageEnglish (US)
Pages (from-to)1429-1435
Number of pages7
JournalJournal of the American Geriatrics Society
Volume54
Issue number9
DOIs
StatePublished - Sep 1 2006

Keywords

  • Anemia
  • Elderly
  • Executive function
  • Trail Making Test

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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