Association between Left Atrial Stiffness Index and Atrial Fibrillation Recurrence in Patients Undergoing Left Atrial Ablation

Research output: Contribution to journalArticle

Abstract

Background-Atrial fibrillation (AF) is associated with significant abnormalities of left atrial (LA) systolic and diastolic function. This study describes a novel measure, LA stiffness index, that estimates LA diastolic function and its association with clinical outcomes of catheter ablation. Methods and Results-A total of 219 AF patients referred for ablation (59% paroxysmal, mean CHA2DS2VASc score 1.7±1.4) were enrolled. Atrial pressure and volume loops were prepared from invasive pressure measures and cardiac magnetic resonance imaging volumetric data during sinus rhythm for all patients. An LA stiffness index was created, defined by the ratio of change in LA pressure to volume during passive filling of LA (ΔP/ΔV). Patients were followed prospectively. Mean LA stiffness index for AF patients was 0.6±0.5 mm Hg/mL (paroxysmal AF 0.51±0.4 and persistent AF 0.73±0.6; P

Original languageEnglish (US)
Article numbere003163
JournalCirculation: Arrhythmia and Electrophysiology
Volume9
Issue number3
DOIs
StatePublished - Mar 1 2016

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Atrial Fibrillation
Recurrence
Atrial Pressure
Left Atrial Function
Catheter Ablation
Magnetic Resonance Imaging
Pressure

Keywords

  • atrial fibrillation
  • catheter ablation
  • magnetic resonance imaging
  • recurrence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

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title = "Association between Left Atrial Stiffness Index and Atrial Fibrillation Recurrence in Patients Undergoing Left Atrial Ablation",
abstract = "Background-Atrial fibrillation (AF) is associated with significant abnormalities of left atrial (LA) systolic and diastolic function. This study describes a novel measure, LA stiffness index, that estimates LA diastolic function and its association with clinical outcomes of catheter ablation. Methods and Results-A total of 219 AF patients referred for ablation (59{\%} paroxysmal, mean CHA2DS2VASc score 1.7±1.4) were enrolled. Atrial pressure and volume loops were prepared from invasive pressure measures and cardiac magnetic resonance imaging volumetric data during sinus rhythm for all patients. An LA stiffness index was created, defined by the ratio of change in LA pressure to volume during passive filling of LA (ΔP/ΔV). Patients were followed prospectively. Mean LA stiffness index for AF patients was 0.6±0.5 mm Hg/mL (paroxysmal AF 0.51±0.4 and persistent AF 0.73±0.6; P",
keywords = "atrial fibrillation, catheter ablation, magnetic resonance imaging, recurrence",
author = "Khurram, {Irfan M.} and Farhan Maqbool and Berger, {Ronald D} and Joseph Marine and Spragg, {David D} and Hiroshi Ashikaga and Vadim Zipunnikov and Kass, {David A} and Hugh Calkins and Saman Nazarian and Stefan Zimmerman",
year = "2016",
month = "3",
day = "1",
doi = "10.1161/CIRCEP.115.003163",
language = "English (US)",
volume = "9",
journal = "Circulation: Arrhythmia and Electrophysiology",
issn = "1941-3149",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Association between Left Atrial Stiffness Index and Atrial Fibrillation Recurrence in Patients Undergoing Left Atrial Ablation

AU - Khurram, Irfan M.

AU - Maqbool, Farhan

AU - Berger, Ronald D

AU - Marine, Joseph

AU - Spragg, David D

AU - Ashikaga, Hiroshi

AU - Zipunnikov, Vadim

AU - Kass, David A

AU - Calkins, Hugh

AU - Nazarian, Saman

AU - Zimmerman, Stefan

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background-Atrial fibrillation (AF) is associated with significant abnormalities of left atrial (LA) systolic and diastolic function. This study describes a novel measure, LA stiffness index, that estimates LA diastolic function and its association with clinical outcomes of catheter ablation. Methods and Results-A total of 219 AF patients referred for ablation (59% paroxysmal, mean CHA2DS2VASc score 1.7±1.4) were enrolled. Atrial pressure and volume loops were prepared from invasive pressure measures and cardiac magnetic resonance imaging volumetric data during sinus rhythm for all patients. An LA stiffness index was created, defined by the ratio of change in LA pressure to volume during passive filling of LA (ΔP/ΔV). Patients were followed prospectively. Mean LA stiffness index for AF patients was 0.6±0.5 mm Hg/mL (paroxysmal AF 0.51±0.4 and persistent AF 0.73±0.6; P

AB - Background-Atrial fibrillation (AF) is associated with significant abnormalities of left atrial (LA) systolic and diastolic function. This study describes a novel measure, LA stiffness index, that estimates LA diastolic function and its association with clinical outcomes of catheter ablation. Methods and Results-A total of 219 AF patients referred for ablation (59% paroxysmal, mean CHA2DS2VASc score 1.7±1.4) were enrolled. Atrial pressure and volume loops were prepared from invasive pressure measures and cardiac magnetic resonance imaging volumetric data during sinus rhythm for all patients. An LA stiffness index was created, defined by the ratio of change in LA pressure to volume during passive filling of LA (ΔP/ΔV). Patients were followed prospectively. Mean LA stiffness index for AF patients was 0.6±0.5 mm Hg/mL (paroxysmal AF 0.51±0.4 and persistent AF 0.73±0.6; P

KW - atrial fibrillation

KW - catheter ablation

KW - magnetic resonance imaging

KW - recurrence

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