@article{3aa588824bfd4304af76d21a1047fda3,
title = "Association between inflammatory markers and myocardial fibrosis the mesa",
abstract = "Inflammation promotes adverse ventricular remodeling. T1 mapping has been used to noninvasively assess interstitial myocardial fibrosis. We examined the association of baseline markers of systemic inflammation with interstitial myocardial fibrosis measured by extracellular volume fraction (ECV) and native T1 mapping at 10-year follow-up in the MESA (Multi-Ethnic Study of Atherosclerosis). Seven hundred seventy-two participants had complete baseline data and underwent cardiac magnetic resonance imaging. All analyses were stratified by sex. Multivariable linear regression models were constructed to assess the associations of baseline CRP (C-reactive protein), IL (interleukin)-6, and fibrinogen with native T1 time and ECV. Longer native T1 times and higher percentages of ECV represent increasing myocardial fibrosis. A 1-SD increment of log-transformed IL-6 levels was associated with 0.4% higher ECV in men (β=0.4; P=0.05). CRP and fibrinogen were not associated to ECV. A 1-SD increment in the log-transformed CRP levels was associated with 4.9 ms higher native T1 (β=4.9; P=0.03). In women, the inflammatory markers did not demonstrate association with native T1 nor ECV. Higher IL-6 and CRP levels are associated with increased interstitial myocardial fibrosis assessed by cardiac magnetic resonance in men. However, no inflammatory markers were associated to myocardial fibrosis in women.",
keywords = "C-reactive protein, Heart ventricles, Inflammation, Interleukin 6, Magnetic resonance imaging, Ventricular remodeling",
author = "Marques, {Mateus D.} and Victor Nauffal and Bharath Ambale-Venkatesh and Vasconcellos, {Henrique D.} and Colin Wu and Hossein Bahrami and Tracy, {Russell P.} and Mary Cushman and Bluemke, {David A.} and Lima, {Jo{\~a}o A.C.}",
note = "Funding Information: We thank the other investigators, the staff, and the participants of the MESA (Multi-Ethnic Study of Atherosclerosis) for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org. This research was supported by contracts N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, and N01-HC-95169 from the National Heart, Lung, and Blood Institute; by grants UL1-TR-000040 and UL1-TR-001079 from National Center for Research Resources National Institutes of Health Intramural Research Program, and by a grant from Bayer Healthcare for the use of gadolinium contrast agent. The views expressed in this article are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the US Department of Health and Human Services. Funding Information: This research was supported by contracts N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, and N01-HC-95169 from the National Heart, Lung, and Blood Institute; by grants UL1-TR-000040 and UL1-TR-001079 from National Center for Research Resources National Institutes of Health Intramural Research Program, and by a grant from Bayer Healthcare for the use of gadolinium contrast agent. The views expressed in this article are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the US Department of Health and Human Services. Publisher Copyright: {\textcopyright} 2018 American Heart Association, Inc.",
year = "2018",
doi = "10.1161/HYPERTENSIONAHA.118.11463",
language = "English (US)",
volume = "72",
pages = "902--908",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "4",
}