Association between inflammation and cardiac geometry in chronic kidney disease: Findings from the CRIC study

Jayanta Gupta, Elizabeth A. Dominic, Jeffrey C. Fink, Akinlolu O. Ojo, Ian R. Barrows, Muredach P. Reilly, Raymond R. Townsend, Marshall M. Joffe, Sylvia E. Rosas, Melanie Wolman, Samir S. Patel, Martin G. Keane, Harold I. Feldman, John W. Kusek, Dominic S. Raj, Lawrence J. Appel, Alan S. Go, Jiang He, James P. Lash, Mahboob Rahman

Research output: Contribution to journalArticle

Abstract

Background: Left ventricular hypertrophy (LVH) and myocardial contractile dysfunction are independent predictors of mortality in patients with chronic kidney disease (CKD). The association between inflammatory biomarkers and cardiac geometry has not yet been studied in a large cohort of CKD patients with a wide range of kidney function. Methods: Plasma levels of interleukin (IL)-1β, IL-1 receptor antagonist (IL-1RA), IL-6, tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β, high-sensitivity C-Reactive protein (hs- CRP), fibrinogen and serum albumin were measured in 3,939 Chronic Renal Insufficiency Cohort study participants. Echocardiography was performed according to the recommendations of the American Society of Echocardiography and interpreted at a centralized core laboratory. Results: LVH, systolic dysfunction and diastolic dysfunction were present in 52.3%, 11.8% and 76.3% of the study subjects, respectively. In logistic regression analysis adjusted for age, sex, race/ethnicity, diabetic status, current smoking status, systolic blood pressure, urinary albumin- creatinine ratio and estimated glomerular filtration rate, hs-CRP (OR 1.26 [95% CI 1.16, 1.37], p

Original languageEnglish (US)
Article numbere0124772
JournalPLoS One
Volume10
Issue number4
DOIs
StatePublished - Apr 24 2015

Fingerprint

interleukin-1
kidney diseases
Chronic Renal Insufficiency
hypertrophy
inflammation
Left Ventricular Hypertrophy
Inflammation
Echocardiography
transforming growth factors
glomerular filtration rate
Interleukin-1 Receptors
Geometry
tumor necrosis factors
C-reactive protein
echocardiography
Blood pressure
fibrinogen
systolic blood pressure
Transforming Growth Factors
Biomarkers

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Association between inflammation and cardiac geometry in chronic kidney disease : Findings from the CRIC study. / Gupta, Jayanta; Dominic, Elizabeth A.; Fink, Jeffrey C.; Ojo, Akinlolu O.; Barrows, Ian R.; Reilly, Muredach P.; Townsend, Raymond R.; Joffe, Marshall M.; Rosas, Sylvia E.; Wolman, Melanie; Patel, Samir S.; Keane, Martin G.; Feldman, Harold I.; Kusek, John W.; Raj, Dominic S.; Appel, Lawrence J.; Go, Alan S.; He, Jiang; Lash, James P.; Rahman, Mahboob.

In: PLoS One, Vol. 10, No. 4, e0124772, 24.04.2015.

Research output: Contribution to journalArticle

Gupta, J, Dominic, EA, Fink, JC, Ojo, AO, Barrows, IR, Reilly, MP, Townsend, RR, Joffe, MM, Rosas, SE, Wolman, M, Patel, SS, Keane, MG, Feldman, HI, Kusek, JW, Raj, DS, Appel, LJ, Go, AS, He, J, Lash, JP & Rahman, M 2015, 'Association between inflammation and cardiac geometry in chronic kidney disease: Findings from the CRIC study', PLoS One, vol. 10, no. 4, e0124772. https://doi.org/10.1371/journal.pone.0124772
Gupta, Jayanta ; Dominic, Elizabeth A. ; Fink, Jeffrey C. ; Ojo, Akinlolu O. ; Barrows, Ian R. ; Reilly, Muredach P. ; Townsend, Raymond R. ; Joffe, Marshall M. ; Rosas, Sylvia E. ; Wolman, Melanie ; Patel, Samir S. ; Keane, Martin G. ; Feldman, Harold I. ; Kusek, John W. ; Raj, Dominic S. ; Appel, Lawrence J. ; Go, Alan S. ; He, Jiang ; Lash, James P. ; Rahman, Mahboob. / Association between inflammation and cardiac geometry in chronic kidney disease : Findings from the CRIC study. In: PLoS One. 2015 ; Vol. 10, No. 4.
@article{1c12866bad5e4f44a3e72fd2d964c148,
title = "Association between inflammation and cardiac geometry in chronic kidney disease: Findings from the CRIC study",
abstract = "Background: Left ventricular hypertrophy (LVH) and myocardial contractile dysfunction are independent predictors of mortality in patients with chronic kidney disease (CKD). The association between inflammatory biomarkers and cardiac geometry has not yet been studied in a large cohort of CKD patients with a wide range of kidney function. Methods: Plasma levels of interleukin (IL)-1β, IL-1 receptor antagonist (IL-1RA), IL-6, tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β, high-sensitivity C-Reactive protein (hs- CRP), fibrinogen and serum albumin were measured in 3,939 Chronic Renal Insufficiency Cohort study participants. Echocardiography was performed according to the recommendations of the American Society of Echocardiography and interpreted at a centralized core laboratory. Results: LVH, systolic dysfunction and diastolic dysfunction were present in 52.3{\%}, 11.8{\%} and 76.3{\%} of the study subjects, respectively. In logistic regression analysis adjusted for age, sex, race/ethnicity, diabetic status, current smoking status, systolic blood pressure, urinary albumin- creatinine ratio and estimated glomerular filtration rate, hs-CRP (OR 1.26 [95{\%} CI 1.16, 1.37], p",
author = "Jayanta Gupta and Dominic, {Elizabeth A.} and Fink, {Jeffrey C.} and Ojo, {Akinlolu O.} and Barrows, {Ian R.} and Reilly, {Muredach P.} and Townsend, {Raymond R.} and Joffe, {Marshall M.} and Rosas, {Sylvia E.} and Melanie Wolman and Patel, {Samir S.} and Keane, {Martin G.} and Feldman, {Harold I.} and Kusek, {John W.} and Raj, {Dominic S.} and Appel, {Lawrence J.} and Go, {Alan S.} and Jiang He and Lash, {James P.} and Mahboob Rahman",
year = "2015",
month = "4",
day = "24",
doi = "10.1371/journal.pone.0124772",
language = "English (US)",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

TY - JOUR

T1 - Association between inflammation and cardiac geometry in chronic kidney disease

T2 - Findings from the CRIC study

AU - Gupta, Jayanta

AU - Dominic, Elizabeth A.

AU - Fink, Jeffrey C.

AU - Ojo, Akinlolu O.

AU - Barrows, Ian R.

AU - Reilly, Muredach P.

AU - Townsend, Raymond R.

AU - Joffe, Marshall M.

AU - Rosas, Sylvia E.

AU - Wolman, Melanie

AU - Patel, Samir S.

AU - Keane, Martin G.

AU - Feldman, Harold I.

AU - Kusek, John W.

AU - Raj, Dominic S.

AU - Appel, Lawrence J.

AU - Go, Alan S.

AU - He, Jiang

AU - Lash, James P.

AU - Rahman, Mahboob

PY - 2015/4/24

Y1 - 2015/4/24

N2 - Background: Left ventricular hypertrophy (LVH) and myocardial contractile dysfunction are independent predictors of mortality in patients with chronic kidney disease (CKD). The association between inflammatory biomarkers and cardiac geometry has not yet been studied in a large cohort of CKD patients with a wide range of kidney function. Methods: Plasma levels of interleukin (IL)-1β, IL-1 receptor antagonist (IL-1RA), IL-6, tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β, high-sensitivity C-Reactive protein (hs- CRP), fibrinogen and serum albumin were measured in 3,939 Chronic Renal Insufficiency Cohort study participants. Echocardiography was performed according to the recommendations of the American Society of Echocardiography and interpreted at a centralized core laboratory. Results: LVH, systolic dysfunction and diastolic dysfunction were present in 52.3%, 11.8% and 76.3% of the study subjects, respectively. In logistic regression analysis adjusted for age, sex, race/ethnicity, diabetic status, current smoking status, systolic blood pressure, urinary albumin- creatinine ratio and estimated glomerular filtration rate, hs-CRP (OR 1.26 [95% CI 1.16, 1.37], p

AB - Background: Left ventricular hypertrophy (LVH) and myocardial contractile dysfunction are independent predictors of mortality in patients with chronic kidney disease (CKD). The association between inflammatory biomarkers and cardiac geometry has not yet been studied in a large cohort of CKD patients with a wide range of kidney function. Methods: Plasma levels of interleukin (IL)-1β, IL-1 receptor antagonist (IL-1RA), IL-6, tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β, high-sensitivity C-Reactive protein (hs- CRP), fibrinogen and serum albumin were measured in 3,939 Chronic Renal Insufficiency Cohort study participants. Echocardiography was performed according to the recommendations of the American Society of Echocardiography and interpreted at a centralized core laboratory. Results: LVH, systolic dysfunction and diastolic dysfunction were present in 52.3%, 11.8% and 76.3% of the study subjects, respectively. In logistic regression analysis adjusted for age, sex, race/ethnicity, diabetic status, current smoking status, systolic blood pressure, urinary albumin- creatinine ratio and estimated glomerular filtration rate, hs-CRP (OR 1.26 [95% CI 1.16, 1.37], p

UR - http://www.scopus.com/inward/record.url?scp=84929353620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929353620&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0124772

DO - 10.1371/journal.pone.0124772

M3 - Article

C2 - 25909952

AN - SCOPUS:84929353620

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 4

M1 - e0124772

ER -