Association between inflammation and cardiac geometry in chronic kidney disease: Findings from the CRIC study

Jayanta Gupta, Elizabeth A. Dominic, Jeffrey C. Fink, Akinlolu O. Ojo, Ian R. Barrows, Muredach P. Reilly, Raymond R. Townsend, Marshall M. Joffe, Sylvia E. Rosas, Melanie Wolman, Samir S. Patel, Martin G. Keane, Harold I. Feldman, John W. Kusek, Dominic S. Raj, Lawrence J. Appel, Alan S. Go, Jiang He, James P. Lash, Mahboob Rahman

Research output: Contribution to journalArticle

Abstract

Background: Left ventricular hypertrophy (LVH) and myocardial contractile dysfunction are independent predictors of mortality in patients with chronic kidney disease (CKD). The association between inflammatory biomarkers and cardiac geometry has not yet been studied in a large cohort of CKD patients with a wide range of kidney function. Methods: Plasma levels of interleukin (IL)-1β, IL-1 receptor antagonist (IL-1RA), IL-6, tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β, high-sensitivity C-Reactive protein (hs- CRP), fibrinogen and serum albumin were measured in 3,939 Chronic Renal Insufficiency Cohort study participants. Echocardiography was performed according to the recommendations of the American Society of Echocardiography and interpreted at a centralized core laboratory. Results: LVH, systolic dysfunction and diastolic dysfunction were present in 52.3%, 11.8% and 76.3% of the study subjects, respectively. In logistic regression analysis adjusted for age, sex, race/ethnicity, diabetic status, current smoking status, systolic blood pressure, urinary albumin- creatinine ratio and estimated glomerular filtration rate, hs-CRP (OR 1.26 [95% CI 1.16, 1.37], p<0.001), IL-1RA (1.23 [1.13, 1.34], p<0.0001), IL-6 (1.25 [1.14, 1.36], p<0.001) and TNF-α (1.14 [1.04, 1.25], p = 0.004) were associated with LVH. The odds for systolic dysfunction were greater for subjects with elevated levels of hs-CRP (1.32 [1.18, 1.48], p<0.001) and IL-6 (1.34 [1.21, 1.49], p<0.001). Only hs-CRP was associated with diastolic dysfunction (1.14 [1.04, 1.26], p = 0.005). Conclusion: In patients with CKD, elevated plasma levels of hs-CRP and IL-6 are associated with LVH and systolic dysfunction.

Original languageEnglish (US)
Article numbere0124772
JournalPloS one
Volume10
Issue number4
DOIs
StatePublished - Apr 24 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Gupta, J., Dominic, E. A., Fink, J. C., Ojo, A. O., Barrows, I. R., Reilly, M. P., Townsend, R. R., Joffe, M. M., Rosas, S. E., Wolman, M., Patel, S. S., Keane, M. G., Feldman, H. I., Kusek, J. W., Raj, D. S., Appel, L. J., Go, A. S., He, J., Lash, J. P., & Rahman, M. (2015). Association between inflammation and cardiac geometry in chronic kidney disease: Findings from the CRIC study. PloS one, 10(4), [e0124772]. https://doi.org/10.1371/journal.pone.0124772