TY - JOUR
T1 - Association between IL13 polymorphisms and psoriatic arthritis is modified by smoking
AU - Duffin, Kristina Callis
AU - Freeny, Ingrid C.
AU - Schrodi, Steven J.
AU - Wong, Bob
AU - Feng, Bing Jian
AU - Soltani-Arabshahi, Razieh
AU - Rakkhit, Tina
AU - Goldgar, David E.
AU - Krueger, Gerald G.
N1 - Funding Information:
We would like to thank Christopher Hansen, Jason Papenfuss, Jackie Panko, Matthew Hoffman, and Tyler Nelson for their work in enrolling the patients into the Utah Psoriasis Initiative. We would also like to thank Celera Corporation, the National Institutes of Health, and the Genetic Association Information Network for their ongoing support of this work.
PY - 2009
Y1 - 2009
N2 - Genetic and environmental factors influence the development of psoriasis (Ps) and psoriatic arthritis (PsA). Recently, we reported that three IL13 polymorphisms, rs1800925, rs20541, and rs848, on chromosome 5q31 conferred the risk for Ps. IL13 encodes IL-13, a Th2 cytokine, and rs1800925 and rs20541 confer risk of asthma. Further, smoking may increase the risk of developing Ps. We examined the association between IL13 polymorphisms, smoking, and PsA in two Ps sample sets genotyped for rs1800925, rs20541, and rs848. We found that the minor alleles (rs1800925 * T, rs20541 * A, and rs848 * A) were significantly associated with protection from PsA versus controls, and that no association with Ps is seen when the PsA cases are excluded. This effect was strongest with rs1800925 * T (odds ratio (OR) 0.40, P allelic 0.000067). The prevalence of PsA in cases with the rs1800925 * CT or TT genotype is about half that of those with the CC genotype (15.5 vs 32.1%, P=0.0002). However, smoking appears to abrogate this effect (CT/TT/non-smoker, prevalence of PsA 13%, OR 0.20, P=0.0001; CT/TT/smoker, prevalence 38%, OR 0.88, P=0.74, CC/non-smoker, prevalence 42% (reference), CC/smoker prevalence 47%, OR 1.21, P=0.47). This study suggests that IL13 polymorphisms associate most strongly with PsA and that smoking may modulate this effect.
AB - Genetic and environmental factors influence the development of psoriasis (Ps) and psoriatic arthritis (PsA). Recently, we reported that three IL13 polymorphisms, rs1800925, rs20541, and rs848, on chromosome 5q31 conferred the risk for Ps. IL13 encodes IL-13, a Th2 cytokine, and rs1800925 and rs20541 confer risk of asthma. Further, smoking may increase the risk of developing Ps. We examined the association between IL13 polymorphisms, smoking, and PsA in two Ps sample sets genotyped for rs1800925, rs20541, and rs848. We found that the minor alleles (rs1800925 * T, rs20541 * A, and rs848 * A) were significantly associated with protection from PsA versus controls, and that no association with Ps is seen when the PsA cases are excluded. This effect was strongest with rs1800925 * T (odds ratio (OR) 0.40, P allelic 0.000067). The prevalence of PsA in cases with the rs1800925 * CT or TT genotype is about half that of those with the CC genotype (15.5 vs 32.1%, P=0.0002). However, smoking appears to abrogate this effect (CT/TT/non-smoker, prevalence of PsA 13%, OR 0.20, P=0.0001; CT/TT/smoker, prevalence 38%, OR 0.88, P=0.74, CC/non-smoker, prevalence 42% (reference), CC/smoker prevalence 47%, OR 1.21, P=0.47). This study suggests that IL13 polymorphisms associate most strongly with PsA and that smoking may modulate this effect.
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U2 - 10.1038/jid.2009.169
DO - 10.1038/jid.2009.169
M3 - Article
C2 - 19554022
AN - SCOPUS:79958169705
SN - 0022-202X
VL - 129
SP - 2777
EP - 2783
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 12
ER -