Association between idiopathic pulmonary fibrosis and coronary artery disease: A case-control study and cohort analysis

Won Young Kim, Ye Jin Mok, Go Woon Kim, Soo Jin Baek, Young Duk Yun, Sun Ha Jee, Dong Soon Kim

Research output: Contribution to journalArticle

Abstract

Background: Although the increased risk of coronary artery disease (CAD) in the patients with id-iopathic pulmonary fibrosis (IPF) has been reported, there was few detailed information on the risk factors for CAD in IPF. The aim of this study was to investigate the prevalence of CAD in IPF with analysis of other risk factors.

Methods: The subjects were 460 patients (mean age, 65 years; 79% male; 74% current or ex-smoker) diagnosed as IPF at Asan Medical Center and 1, 925 controls matched with age, gender, smoking habits, and date of IPF diagnosis from the cohort of Korean Heart Study. Cardiovascular risk factors and prevalence of CAD in both groups were compared and the incidence of newly developed CAD during follow-up was also analyzed.

Results: IPF group was more diabetic, and control group had a higher proportion of hypertension and hypercholesterolemia. The prevalence of CAD in IPF group (7%) was two times higher than that of control group (3%). Multivariate analysis revealed that age (OR, 1.04; 95% CI, 1.02-1.07), hypertension (OR, 2.13; 95% CI, 1.36-3.33), hypercholesterolemia (OR, 3.85; 95% CI, 2.51-5.88), and IPF (OR, 2.64; 95% CI, 1.68-4.14) were significant risk factors for CAD. During follow-up (median: 2.5 years for IPF and 4.4 years for controls), the incidence of newly diagnosed CAD was higher in the patients with IPF (6.8%) compared to controls (2.8%) (RR, 1.92; 95% CI, 1.08-3.43).

Conclusions: IPF itself was an independent risk factor for CAD after the adjustment of age, hypertension, diabetes, and hypercholesterolemia.

Original languageEnglish (US)
Pages (from-to)289-296
Number of pages8
JournalSarcoidosis Vasculitis and Diffuse Lung Diseases
Volume31
Issue number4
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Idiopathic Pulmonary Fibrosis
Pulmonary Fibrosis
Pulmonary Artery
Case-Control Studies
Coronary Artery Disease
Cohort Studies
Hypercholesterolemia
Hypertension
Social Adjustment
Control Groups
Incidence
Habits
Multivariate Analysis
Smoking

Keywords

  • Coronary artery disease
  • Incidence
  • IPF
  • Risk factors

ASJC Scopus subject areas

  • Internal Medicine
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Association between idiopathic pulmonary fibrosis and coronary artery disease : A case-control study and cohort analysis. / Kim, Won Young; Mok, Ye Jin; Kim, Go Woon; Baek, Soo Jin; Yun, Young Duk; Jee, Sun Ha; Kim, Dong Soon.

In: Sarcoidosis Vasculitis and Diffuse Lung Diseases, Vol. 31, No. 4, 01.01.2014, p. 289-296.

Research output: Contribution to journalArticle

Kim, Won Young ; Mok, Ye Jin ; Kim, Go Woon ; Baek, Soo Jin ; Yun, Young Duk ; Jee, Sun Ha ; Kim, Dong Soon. / Association between idiopathic pulmonary fibrosis and coronary artery disease : A case-control study and cohort analysis. In: Sarcoidosis Vasculitis and Diffuse Lung Diseases. 2014 ; Vol. 31, No. 4. pp. 289-296.
@article{5c324ea09c964a51b5dc95590a9c9ebf,
title = "Association between idiopathic pulmonary fibrosis and coronary artery disease: A case-control study and cohort analysis",
abstract = "Background: Although the increased risk of coronary artery disease (CAD) in the patients with id-iopathic pulmonary fibrosis (IPF) has been reported, there was few detailed information on the risk factors for CAD in IPF. The aim of this study was to investigate the prevalence of CAD in IPF with analysis of other risk factors.Methods: The subjects were 460 patients (mean age, 65 years; 79{\%} male; 74{\%} current or ex-smoker) diagnosed as IPF at Asan Medical Center and 1, 925 controls matched with age, gender, smoking habits, and date of IPF diagnosis from the cohort of Korean Heart Study. Cardiovascular risk factors and prevalence of CAD in both groups were compared and the incidence of newly developed CAD during follow-up was also analyzed.Results: IPF group was more diabetic, and control group had a higher proportion of hypertension and hypercholesterolemia. The prevalence of CAD in IPF group (7{\%}) was two times higher than that of control group (3{\%}). Multivariate analysis revealed that age (OR, 1.04; 95{\%} CI, 1.02-1.07), hypertension (OR, 2.13; 95{\%} CI, 1.36-3.33), hypercholesterolemia (OR, 3.85; 95{\%} CI, 2.51-5.88), and IPF (OR, 2.64; 95{\%} CI, 1.68-4.14) were significant risk factors for CAD. During follow-up (median: 2.5 years for IPF and 4.4 years for controls), the incidence of newly diagnosed CAD was higher in the patients with IPF (6.8{\%}) compared to controls (2.8{\%}) (RR, 1.92; 95{\%} CI, 1.08-3.43).Conclusions: IPF itself was an independent risk factor for CAD after the adjustment of age, hypertension, diabetes, and hypercholesterolemia.",
keywords = "Coronary artery disease, Incidence, IPF, Risk factors",
author = "Kim, {Won Young} and Mok, {Ye Jin} and Kim, {Go Woon} and Baek, {Soo Jin} and Yun, {Young Duk} and Jee, {Sun Ha} and Kim, {Dong Soon}",
year = "2014",
month = "1",
day = "1",
language = "English (US)",
volume = "31",
pages = "289--296",
journal = "Sarcoidosis Vasculitis and Diffuse Lung Diseases",
issn = "1124-0490",
publisher = "Mattioli 1885 S.p.A.",
number = "4",

}

TY - JOUR

T1 - Association between idiopathic pulmonary fibrosis and coronary artery disease

T2 - A case-control study and cohort analysis

AU - Kim, Won Young

AU - Mok, Ye Jin

AU - Kim, Go Woon

AU - Baek, Soo Jin

AU - Yun, Young Duk

AU - Jee, Sun Ha

AU - Kim, Dong Soon

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Although the increased risk of coronary artery disease (CAD) in the patients with id-iopathic pulmonary fibrosis (IPF) has been reported, there was few detailed information on the risk factors for CAD in IPF. The aim of this study was to investigate the prevalence of CAD in IPF with analysis of other risk factors.Methods: The subjects were 460 patients (mean age, 65 years; 79% male; 74% current or ex-smoker) diagnosed as IPF at Asan Medical Center and 1, 925 controls matched with age, gender, smoking habits, and date of IPF diagnosis from the cohort of Korean Heart Study. Cardiovascular risk factors and prevalence of CAD in both groups were compared and the incidence of newly developed CAD during follow-up was also analyzed.Results: IPF group was more diabetic, and control group had a higher proportion of hypertension and hypercholesterolemia. The prevalence of CAD in IPF group (7%) was two times higher than that of control group (3%). Multivariate analysis revealed that age (OR, 1.04; 95% CI, 1.02-1.07), hypertension (OR, 2.13; 95% CI, 1.36-3.33), hypercholesterolemia (OR, 3.85; 95% CI, 2.51-5.88), and IPF (OR, 2.64; 95% CI, 1.68-4.14) were significant risk factors for CAD. During follow-up (median: 2.5 years for IPF and 4.4 years for controls), the incidence of newly diagnosed CAD was higher in the patients with IPF (6.8%) compared to controls (2.8%) (RR, 1.92; 95% CI, 1.08-3.43).Conclusions: IPF itself was an independent risk factor for CAD after the adjustment of age, hypertension, diabetes, and hypercholesterolemia.

AB - Background: Although the increased risk of coronary artery disease (CAD) in the patients with id-iopathic pulmonary fibrosis (IPF) has been reported, there was few detailed information on the risk factors for CAD in IPF. The aim of this study was to investigate the prevalence of CAD in IPF with analysis of other risk factors.Methods: The subjects were 460 patients (mean age, 65 years; 79% male; 74% current or ex-smoker) diagnosed as IPF at Asan Medical Center and 1, 925 controls matched with age, gender, smoking habits, and date of IPF diagnosis from the cohort of Korean Heart Study. Cardiovascular risk factors and prevalence of CAD in both groups were compared and the incidence of newly developed CAD during follow-up was also analyzed.Results: IPF group was more diabetic, and control group had a higher proportion of hypertension and hypercholesterolemia. The prevalence of CAD in IPF group (7%) was two times higher than that of control group (3%). Multivariate analysis revealed that age (OR, 1.04; 95% CI, 1.02-1.07), hypertension (OR, 2.13; 95% CI, 1.36-3.33), hypercholesterolemia (OR, 3.85; 95% CI, 2.51-5.88), and IPF (OR, 2.64; 95% CI, 1.68-4.14) were significant risk factors for CAD. During follow-up (median: 2.5 years for IPF and 4.4 years for controls), the incidence of newly diagnosed CAD was higher in the patients with IPF (6.8%) compared to controls (2.8%) (RR, 1.92; 95% CI, 1.08-3.43).Conclusions: IPF itself was an independent risk factor for CAD after the adjustment of age, hypertension, diabetes, and hypercholesterolemia.

KW - Coronary artery disease

KW - Incidence

KW - IPF

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=84920414044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920414044&partnerID=8YFLogxK

M3 - Article

C2 - 25591140

AN - SCOPUS:84920414044

VL - 31

SP - 289

EP - 296

JO - Sarcoidosis Vasculitis and Diffuse Lung Diseases

JF - Sarcoidosis Vasculitis and Diffuse Lung Diseases

SN - 1124-0490

IS - 4

ER -