TY - JOUR
T1 - Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women
AU - Chu, Kathryn
AU - Jiamton, Sukhum
AU - Pepin, Jacques
AU - Cowan, Frances
AU - Mahakkanukrauh, Bussakorn
AU - Suttent, Ruengpung
AU - Robinson, Noah J.
AU - Deslandes, Sylvie
AU - Frost, Eric
AU - Chaisilwattana, Pongsakdi
AU - Suthipinittharm, Puan
AU - Grosskurth, Heiner
AU - Brown, David
AU - Jaffar, Shabbar
PY - 2006
Y1 - 2006
N2 - We studied the association between herpes simplex virus type-2 (HSV-2) and HIV-1 viralload in plasma, semen, cervico-vaginal secretions and genital ulcers. Forty-seven (68%) men and 57 (80%) women were HSV-2 antibody positive, of whom 12 (26%, 95% confidence interval [CI] 20, 32) and five (8%, 95% CI 4, 12), respectively, had HSV-2 genital shedding detected by polymerase chain reaction. The mean HIV-1 seminal and cervico-vaginal viral loads did not differ significantly according to the presence of HSV-2 shedding. Eleven men and 15 women presented with genital ulcers; all ulcers were due to HSV-2. Ten men and nine women were followed up over six days: the mean (95% CI) HIV-1 log viral load copies/mL in the genital ulcers at baseline and final visits were 2.5 (2.3, 2.7) and 3.1 (2.0, 4.2) for men and 3.0 (2.6, 3.4) and 2.7 (2.3, 3.1) for women. These findings do not support the hypothesis that HSV-2 increases the HIV-1 viral load in genital secretions.
AB - We studied the association between herpes simplex virus type-2 (HSV-2) and HIV-1 viralload in plasma, semen, cervico-vaginal secretions and genital ulcers. Forty-seven (68%) men and 57 (80%) women were HSV-2 antibody positive, of whom 12 (26%, 95% confidence interval [CI] 20, 32) and five (8%, 95% CI 4, 12), respectively, had HSV-2 genital shedding detected by polymerase chain reaction. The mean HIV-1 seminal and cervico-vaginal viral loads did not differ significantly according to the presence of HSV-2 shedding. Eleven men and 15 women presented with genital ulcers; all ulcers were due to HSV-2. Ten men and nine women were followed up over six days: the mean (95% CI) HIV-1 log viral load copies/mL in the genital ulcers at baseline and final visits were 2.5 (2.3, 2.7) and 3.1 (2.0, 4.2) for men and 3.0 (2.6, 3.4) and 2.7 (2.3, 3.1) for women. These findings do not support the hypothesis that HSV-2 increases the HIV-1 viral load in genital secretions.
KW - HIV-1
KW - HSV-2
KW - Thailand
KW - Viral load
UR - http://www.scopus.com/inward/record.url?scp=33750231632&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750231632&partnerID=8YFLogxK
U2 - 10.1258/095646206780071108
DO - 10.1258/095646206780071108
M3 - Article
C2 - 17059638
AN - SCOPUS:33750231632
VL - 17
SP - 681
EP - 686
JO - International Journal of STD and AIDS
JF - International Journal of STD and AIDS
SN - 0956-4624
IS - 10
ER -