Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women

Kathryn Chu; Sukhum Jiamton; Jacques Pepin; Frances Cowan; Bussakorn Mahakkanukrauh; Ruengpung Suttent; Noah J. Robinson; Sylvie Deslandes; Eric Frost; Pongsakdi Chaisilwattana; Puan Suthipinittharm; Heiner Grosskurth; David Brown; Shabbar Jaffar

doi:10.1258/095646206780071108

Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women

Kathryn Chu, Sukhum Jiamton, Jacques Pepin, Frances Cowan, Bussakorn Mahakkanukrauh, Ruengpung Suttent, Noah J. Robinson, Sylvie Deslandes, Eric Frost, Pongsakdi Chaisilwattana, Puan Suthipinittharm, Heiner Grosskurth, David Brown, Shabbar Jaffar

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We studied the association between herpes simplex virus type-2 (HSV-2) and HIV-1 viralload in plasma, semen, cervico-vaginal secretions and genital ulcers. Forty-seven (68%) men and 57 (80%) women were HSV-2 antibody positive, of whom 12 (26%, 95% confidence interval [CI] 20, 32) and five (8%, 95% CI 4, 12), respectively, had HSV-2 genital shedding detected by polymerase chain reaction. The mean HIV-1 seminal and cervico-vaginal viral loads did not differ significantly according to the presence of HSV-2 shedding. Eleven men and 15 women presented with genital ulcers; all ulcers were due to HSV-2. Ten men and nine women were followed up over six days: the mean (95% CI) HIV-1 log viral load copies/mL in the genital ulcers at baseline and final visits were 2.5 (2.3, 2.7) and 3.1 (2.0, 4.2) for men and 3.0 (2.6, 3.4) and 2.7 (2.3, 3.1) for women. These findings do not support the hypothesis that HSV-2 increases the HIV-1 viral load in genital secretions.

Original language	English (US)
Pages (from-to)	681-686
Number of pages	6
Journal	International Journal of STD and AIDS
Volume	17
Issue number	10
DOIs	https://doi.org/10.1258/095646206780071108
State	Published - 2006

Keywords

HIV-1
HSV-2
Thailand
Viral load

ASJC Scopus subject areas

Dermatology
Public Health, Environmental and Occupational Health
Pharmacology (medical)
Infectious Diseases

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Chu, K., Jiamton, S., Pepin, J., Cowan, F., Mahakkanukrauh, B., Suttent, R., Robinson, N. J., Deslandes, S., Frost, E., Chaisilwattana, P., Suthipinittharm, P., Grosskurth, H., Brown, D., & Jaffar, S. (2006). Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women. International Journal of STD and AIDS, 17(10), 681-686. https://doi.org/10.1258/095646206780071108

Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women. / Chu, Kathryn; Jiamton, Sukhum; Pepin, Jacques; Cowan, Frances; Mahakkanukrauh, Bussakorn; Suttent, Ruengpung; Robinson, Noah J.; Deslandes, Sylvie; Frost, Eric; Chaisilwattana, Pongsakdi; Suthipinittharm, Puan; Grosskurth, Heiner; Brown, David; Jaffar, Shabbar.

In: International Journal of STD and AIDS, Vol. 17, No. 10, 2006, p. 681-686.

Research output: Contribution to journal › Article › peer-review

Chu, K, Jiamton, S, Pepin, J, Cowan, F, Mahakkanukrauh, B, Suttent, R, Robinson, NJ, Deslandes, S, Frost, E, Chaisilwattana, P, Suthipinittharm, P, Grosskurth, H, Brown, D & Jaffar, S 2006, 'Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women', International Journal of STD and AIDS, vol. 17, no. 10, pp. 681-686. https://doi.org/10.1258/095646206780071108

Chu, Kathryn ; Jiamton, Sukhum ; Pepin, Jacques ; Cowan, Frances ; Mahakkanukrauh, Bussakorn ; Suttent, Ruengpung ; Robinson, Noah J. ; Deslandes, Sylvie ; Frost, Eric ; Chaisilwattana, Pongsakdi ; Suthipinittharm, Puan ; Grosskurth, Heiner ; Brown, David ; Jaffar, Shabbar. / Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women. In: International Journal of STD and AIDS. 2006 ; Vol. 17, No. 10. pp. 681-686.

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abstract = "We studied the association between herpes simplex virus type-2 (HSV-2) and HIV-1 viralload in plasma, semen, cervico-vaginal secretions and genital ulcers. Forty-seven (68%) men and 57 (80%) women were HSV-2 antibody positive, of whom 12 (26%, 95% confidence interval [CI] 20, 32) and five (8%, 95% CI 4, 12), respectively, had HSV-2 genital shedding detected by polymerase chain reaction. The mean HIV-1 seminal and cervico-vaginal viral loads did not differ significantly according to the presence of HSV-2 shedding. Eleven men and 15 women presented with genital ulcers; all ulcers were due to HSV-2. Ten men and nine women were followed up over six days: the mean (95% CI) HIV-1 log viral load copies/mL in the genital ulcers at baseline and final visits were 2.5 (2.3, 2.7) and 3.1 (2.0, 4.2) for men and 3.0 (2.6, 3.4) and 2.7 (2.3, 3.1) for women. These findings do not support the hypothesis that HSV-2 increases the HIV-1 viral load in genital secretions.",

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AU - Mahakkanukrauh, Bussakorn

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AB - We studied the association between herpes simplex virus type-2 (HSV-2) and HIV-1 viralload in plasma, semen, cervico-vaginal secretions and genital ulcers. Forty-seven (68%) men and 57 (80%) women were HSV-2 antibody positive, of whom 12 (26%, 95% confidence interval [CI] 20, 32) and five (8%, 95% CI 4, 12), respectively, had HSV-2 genital shedding detected by polymerase chain reaction. The mean HIV-1 seminal and cervico-vaginal viral loads did not differ significantly according to the presence of HSV-2 shedding. Eleven men and 15 women presented with genital ulcers; all ulcers were due to HSV-2. Ten men and nine women were followed up over six days: the mean (95% CI) HIV-1 log viral load copies/mL in the genital ulcers at baseline and final visits were 2.5 (2.3, 2.7) and 3.1 (2.0, 4.2) for men and 3.0 (2.6, 3.4) and 2.7 (2.3, 3.1) for women. These findings do not support the hypothesis that HSV-2 increases the HIV-1 viral load in genital secretions.

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Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women

Abstract

Keywords

ASJC Scopus subject areas

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