Association between hormones and metabolic syndrome in older Italian men

Marcello Maggio, Fulvio Lauretani, Gian Paolo Ceda, Stefania Bandinelli, Shehzad Basaria, Alessandro Ble, Josephine Egan, Giuseppe Paolisso, Samer Najjar, E. Jeffrey Metter, Giorgio Valenti, Jack M. Guralnik, Luigi Ferrucci

Research output: Contribution to journalArticle


OBJECTIVES: To determine whether low levels of testosterone, sex hormone binding globulin (SHBG), insulin-like growth factor-1 (IGF-1), and dehydroepiandrosterone sulfate (DHEAS) and high levels of cortisol and leptin would be associated with metabolic syndrome (MS). DESIGN: Cross-sectional. SETTING: Population-based sample of older Italian men. PARTICIPANTS: Four hundred fifty-two men aged 65 and older enrolled in the Invecchiare in Chianti (InCHIANTI) study. MEASUREMENTS: Complete data on testosterone, cortisol, DHEAS, SHBG, fasting insulin, IGF-1 and leptin. MS was defined according to Adult Treatment Panel III criteria. RESULTS: MS was present in 73 men (15.8% of the sample). After adjusting for confounders, total testosterone (P

Original languageEnglish (US)
Pages (from-to)1832-1838
Number of pages7
JournalJournal of the American Geriatrics Society
Issue number12
StatePublished - Dec 2006
Externally publishedYes



  • Hormonal dysregulation
  • Metabolic syndrome
  • Older men
  • SHBG
  • Testosterone

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Maggio, M., Lauretani, F., Ceda, G. P., Bandinelli, S., Basaria, S., Ble, A., Egan, J., Paolisso, G., Najjar, S., Jeffrey Metter, E., Valenti, G., Guralnik, J. M., & Ferrucci, L. (2006). Association between hormones and metabolic syndrome in older Italian men. Journal of the American Geriatrics Society, 54(12), 1832-1838.