Association between high-density lipoprotein subfractions and low-grade inflammation, insulin resistance, and metabolic syndrome components: The ELSA-Brasil study

Giuliano Generoso, Isabela M. Bensenor, Raul D. Santos, Itamar S. Santos, Alessandra C. Goulart, Steven Jones, Krishnaji R. Kulkarni, Michael Blaha, Peter P. Toth, Paulo A. Lotufo, Marcio Sommer Bittencourt

Research output: Contribution to journalArticle

Abstract

Background: High-density lipoprotein cholesterol (HDL-C) can be divided into subfractions, which may have variable effects in atherogenesis. The results about the association between HDL-C subfractions and risk factors for cardiovascular disease are mixed. Objective: The objective of this study was to analyze the association between HDL-C subfractions and each metabolic syndrome component, homeostasis model assessment-estimated insulin resistance (HOMA-IR) and C-reactive protein (CRP). Methods: Four thousand five hundred thirty-two individuals between 35 and 74 years old without previous manifest cardiovascular disease not using fibrates were enrolled. HDL-C subfractions were separated by vertical ultracentrifugation (vertical auto profile—in mg/dL) into HDL2-C and HDL3-C. HDL2-C/HDL3-C ratio, HOMA-IR, and high-sensitivity CRP were also included in the analysis. Results: Mean age of participants was 51 ± 9 years, and 54.8% were women. In univariate analysis, HDL-C, HDL2-C, and HDL3-C were all inversely associated with each of the metabolic syndrome defining factors, HOMA-IR values, and serum CRP. We also observed a negative association between HDL2-C/HDL3-C ratio with the variables aforementioned even after adjusting for smoking, alcohol use, physical activity, and HDL-C levels (P < .01). Conclusion: HDL-C and its subfractions (HDL2-C and HDL3-C) are inversely associated with the defining features of metabolic syndrome, insulin resistance, and systemic inflammation. In addition, the HDL2-C/HDL3-C ratio measured by vertical auto profile is significantly associated with the former factors even after comprehensive adjustment for HDL-C and other confounding variables.

Original languageEnglish (US)
JournalJournal of Clinical Lipidology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

HDL Lipoproteins
HDL Cholesterol
Insulin Resistance
Inflammation
C-Reactive Protein
Homeostasis
Cardiovascular Diseases
HDL2 Lipoprotein
Fibric Acids
Confounding Factors (Epidemiology)
Ultracentrifugation
Blood Proteins
Atherosclerosis
Smoking
Alcohols
Exercise

Keywords

  • High-density lipoprotein subfractions
  • Insulin resistance
  • Low-grade inflammation
  • Metabolic syndrome

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

Cite this

Association between high-density lipoprotein subfractions and low-grade inflammation, insulin resistance, and metabolic syndrome components : The ELSA-Brasil study. / Generoso, Giuliano; Bensenor, Isabela M.; Santos, Raul D.; Santos, Itamar S.; Goulart, Alessandra C.; Jones, Steven; Kulkarni, Krishnaji R.; Blaha, Michael; Toth, Peter P.; Lotufo, Paulo A.; Bittencourt, Marcio Sommer.

In: Journal of Clinical Lipidology, 01.01.2018.

Research output: Contribution to journalArticle

Generoso, Giuliano ; Bensenor, Isabela M. ; Santos, Raul D. ; Santos, Itamar S. ; Goulart, Alessandra C. ; Jones, Steven ; Kulkarni, Krishnaji R. ; Blaha, Michael ; Toth, Peter P. ; Lotufo, Paulo A. ; Bittencourt, Marcio Sommer. / Association between high-density lipoprotein subfractions and low-grade inflammation, insulin resistance, and metabolic syndrome components : The ELSA-Brasil study. In: Journal of Clinical Lipidology. 2018.
@article{58fb316e25294287bff83fe694ac2b09,
title = "Association between high-density lipoprotein subfractions and low-grade inflammation, insulin resistance, and metabolic syndrome components: The ELSA-Brasil study",
abstract = "Background: High-density lipoprotein cholesterol (HDL-C) can be divided into subfractions, which may have variable effects in atherogenesis. The results about the association between HDL-C subfractions and risk factors for cardiovascular disease are mixed. Objective: The objective of this study was to analyze the association between HDL-C subfractions and each metabolic syndrome component, homeostasis model assessment-estimated insulin resistance (HOMA-IR) and C-reactive protein (CRP). Methods: Four thousand five hundred thirty-two individuals between 35 and 74 years old without previous manifest cardiovascular disease not using fibrates were enrolled. HDL-C subfractions were separated by vertical ultracentrifugation (vertical auto profile—in mg/dL) into HDL2-C and HDL3-C. HDL2-C/HDL3-C ratio, HOMA-IR, and high-sensitivity CRP were also included in the analysis. Results: Mean age of participants was 51 ± 9 years, and 54.8{\%} were women. In univariate analysis, HDL-C, HDL2-C, and HDL3-C were all inversely associated with each of the metabolic syndrome defining factors, HOMA-IR values, and serum CRP. We also observed a negative association between HDL2-C/HDL3-C ratio with the variables aforementioned even after adjusting for smoking, alcohol use, physical activity, and HDL-C levels (P < .01). Conclusion: HDL-C and its subfractions (HDL2-C and HDL3-C) are inversely associated with the defining features of metabolic syndrome, insulin resistance, and systemic inflammation. In addition, the HDL2-C/HDL3-C ratio measured by vertical auto profile is significantly associated with the former factors even after comprehensive adjustment for HDL-C and other confounding variables.",
keywords = "High-density lipoprotein subfractions, Insulin resistance, Low-grade inflammation, Metabolic syndrome",
author = "Giuliano Generoso and Bensenor, {Isabela M.} and Santos, {Raul D.} and Santos, {Itamar S.} and Goulart, {Alessandra C.} and Steven Jones and Kulkarni, {Krishnaji R.} and Michael Blaha and Toth, {Peter P.} and Lotufo, {Paulo A.} and Bittencourt, {Marcio Sommer}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.jacl.2018.05.003",
language = "English (US)",
journal = "Journal of Clinical Lipidology",
issn = "1933-2874",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Association between high-density lipoprotein subfractions and low-grade inflammation, insulin resistance, and metabolic syndrome components

T2 - The ELSA-Brasil study

AU - Generoso, Giuliano

AU - Bensenor, Isabela M.

AU - Santos, Raul D.

AU - Santos, Itamar S.

AU - Goulart, Alessandra C.

AU - Jones, Steven

AU - Kulkarni, Krishnaji R.

AU - Blaha, Michael

AU - Toth, Peter P.

AU - Lotufo, Paulo A.

AU - Bittencourt, Marcio Sommer

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: High-density lipoprotein cholesterol (HDL-C) can be divided into subfractions, which may have variable effects in atherogenesis. The results about the association between HDL-C subfractions and risk factors for cardiovascular disease are mixed. Objective: The objective of this study was to analyze the association between HDL-C subfractions and each metabolic syndrome component, homeostasis model assessment-estimated insulin resistance (HOMA-IR) and C-reactive protein (CRP). Methods: Four thousand five hundred thirty-two individuals between 35 and 74 years old without previous manifest cardiovascular disease not using fibrates were enrolled. HDL-C subfractions were separated by vertical ultracentrifugation (vertical auto profile—in mg/dL) into HDL2-C and HDL3-C. HDL2-C/HDL3-C ratio, HOMA-IR, and high-sensitivity CRP were also included in the analysis. Results: Mean age of participants was 51 ± 9 years, and 54.8% were women. In univariate analysis, HDL-C, HDL2-C, and HDL3-C were all inversely associated with each of the metabolic syndrome defining factors, HOMA-IR values, and serum CRP. We also observed a negative association between HDL2-C/HDL3-C ratio with the variables aforementioned even after adjusting for smoking, alcohol use, physical activity, and HDL-C levels (P < .01). Conclusion: HDL-C and its subfractions (HDL2-C and HDL3-C) are inversely associated with the defining features of metabolic syndrome, insulin resistance, and systemic inflammation. In addition, the HDL2-C/HDL3-C ratio measured by vertical auto profile is significantly associated with the former factors even after comprehensive adjustment for HDL-C and other confounding variables.

AB - Background: High-density lipoprotein cholesterol (HDL-C) can be divided into subfractions, which may have variable effects in atherogenesis. The results about the association between HDL-C subfractions and risk factors for cardiovascular disease are mixed. Objective: The objective of this study was to analyze the association between HDL-C subfractions and each metabolic syndrome component, homeostasis model assessment-estimated insulin resistance (HOMA-IR) and C-reactive protein (CRP). Methods: Four thousand five hundred thirty-two individuals between 35 and 74 years old without previous manifest cardiovascular disease not using fibrates were enrolled. HDL-C subfractions were separated by vertical ultracentrifugation (vertical auto profile—in mg/dL) into HDL2-C and HDL3-C. HDL2-C/HDL3-C ratio, HOMA-IR, and high-sensitivity CRP were also included in the analysis. Results: Mean age of participants was 51 ± 9 years, and 54.8% were women. In univariate analysis, HDL-C, HDL2-C, and HDL3-C were all inversely associated with each of the metabolic syndrome defining factors, HOMA-IR values, and serum CRP. We also observed a negative association between HDL2-C/HDL3-C ratio with the variables aforementioned even after adjusting for smoking, alcohol use, physical activity, and HDL-C levels (P < .01). Conclusion: HDL-C and its subfractions (HDL2-C and HDL3-C) are inversely associated with the defining features of metabolic syndrome, insulin resistance, and systemic inflammation. In addition, the HDL2-C/HDL3-C ratio measured by vertical auto profile is significantly associated with the former factors even after comprehensive adjustment for HDL-C and other confounding variables.

KW - High-density lipoprotein subfractions

KW - Insulin resistance

KW - Low-grade inflammation

KW - Metabolic syndrome

UR - http://www.scopus.com/inward/record.url?scp=85048886031&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048886031&partnerID=8YFLogxK

U2 - 10.1016/j.jacl.2018.05.003

DO - 10.1016/j.jacl.2018.05.003

M3 - Article

C2 - 29941395

AN - SCOPUS:85048886031

JO - Journal of Clinical Lipidology

JF - Journal of Clinical Lipidology

SN - 1933-2874

ER -