Association between Helicobacter pylori infection and increased risk of typhoid fever

Maharaj K. Bhan, Rajiv Bahl, Sunil Sazawal, Anju Sinha, Ramesh Kumar, Dilip Mahalanabis, John D. Clemens

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Helicobacter pylori infection has been reported to increase the risk of cholera. This nested case-control study was conducted to determine whether H. priori infection is associated with occurrence of typhoid fever. Eighty-three case subjects of culture-proven typhoid fever were identified through a 1-year surveillance of subjects aged 0-40 years in an urban slum. Two age- and sex-matched neighborhood control subjects were concurrently selected for each case subject. Serum anti-H. pylori immunoglobulin G antibodies were measured in case and neighborhood control subjects. For determining other risk factors, 2 additional community control subjects per case were selected. There was a significant association between the presence of serum anti-H. pylori immunoglobulin G antibodies and typhoid fever (adjusted odds ratio, 2.03; 95% confidence interval, 1.02-4.01). Illiteracy, being part of a nuclear family, nonuse of soap, and consumption of ice cream were also associated with a significantly greater risk of typhoid fever. This study provides the first empiric evidence that H. pylori infection is associated with an increased risk of typhoid fever.

Original languageEnglish (US)
Pages (from-to)1857-1860
Number of pages4
JournalJournal of Infectious Diseases
Issue number12
StatePublished - Dec 15 2002
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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