Association between Heat Shock Protein-60 and Development of Atrial Fibrillation: Results from the Multi-Ethnic Study of Atherosclerosis (MESA)

Abhishek Maan, Neal W. Jorgensen, Moussa Mansour, Samuel Dudley, Nancy S. Jenny, Christopher Defilippi, Moyses Szklo, Alvaro Alonso, Marwan M. Refaat, Jeremy Ruskin, Susan R. Heckbert, E. Kevin Heist

Research output: Contribution to journalArticle

Abstract

Background: During atrial fibrillation (AF), a high rate of myocyte activation causes cellular stress and initiates the process of atrial remodeling, which further promotes persistence of AF. Although heat shock proteins (HSPs) have been shown to prevent atrial remodeling and suppress the occurrence of AF in cellular and animal experimental models, increased levels of HSP-60 have been observed in patients with postoperative AF, likely reflecting a response to cellular stress. To better understand the role of HSP-60 in relation to AF, we examined the association of HSP-60 levels in relation to the future development of AF in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: MESA is a cohort study that recruited 6,814 participants aged 45–84 years and free of known cardiovascular disease at baseline (2000–2002) from six field centers. We investigated 983 participants, selected at random from the total cohort, who had HSP-60 measured and were free of AF at baseline. We tested the association of HSP-60 levels with the incidence of AF using multivariate Cox models after adjustment for demographics, clinical characteristics, and biomarkers. Results: During an average of 10.6 years of follow-up, 77 participants developed AF. We did not observe a significant association between the log-transformed HSP-60 levels and development of AF on either unadjusted or multivariate analysis (adjusted hazard ratio: 1.02 per unit difference on natural log scale, 95% confidence interval: 0.77–1.34 ln (ng/mL). Conclusion: Contrary to the findings from the preclinical studies, which demonstrated an important role of HSP-60 in the pathogenesis of AF, we did not observe a significant association between HSP-60 and occurrence of AF.

Original languageEnglish (US)
Pages (from-to)1373-1378
Number of pages6
JournalPACE - Pacing and Clinical Electrophysiology
Volume39
Issue number12
DOIs
StatePublished - Dec 1 2016

Keywords

  • atrial fibrillation
  • atrial stress response
  • heat shock protein

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Maan, A., Jorgensen, N. W., Mansour, M., Dudley, S., Jenny, N. S., Defilippi, C., Szklo, M., Alonso, A., Refaat, M. M., Ruskin, J., Heckbert, S. R., & Heist, E. K. (2016). Association between Heat Shock Protein-60 and Development of Atrial Fibrillation: Results from the Multi-Ethnic Study of Atherosclerosis (MESA). PACE - Pacing and Clinical Electrophysiology, 39(12), 1373-1378. https://doi.org/10.1111/pace.12969