Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand

Sandra Ortiz-Cuaran; Stephanie Villar; Doriane Gouas; Gilles Ferro; Amelie Plymoth; Thiravud Khuhaprema; Anant Kalalak; Suleeporn Sangrajrang; Marlin D. Friesen; John D. Groopman; Pierre Hainaut

doi:10.1016/j.canlet.2012.11.012

Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand

Sandra Ortiz-Cuaran, Stephanie Villar, Doriane Gouas, Gilles Ferro, Amelie Plymoth, Thiravud Khuhaprema, Anant Kalalak, Suleeporn Sangrajrang, Marlin D. Friesen, John D. Groopman, Pierre Hainaut

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Hepatocellular carcinoma (HCC) is associated with hepatitis B virus (HBV) chronicity and dietary exposure to aflatoxin, a mutagen targeting codon 249 of tumor suppressor TP53 (R249S mutation). Based on a case-control in Thailand, we have measured R249S and the status of HBX gene in plasma DNA of 176 cases and 133 referents. Detection of HBX complete sequences was associated with R249S in HCC with no documented prior cirrhosis but not in HCC developing in a context of cirrhosis or in non-cancer chronic liver diseases. Thus, R249S may specifically cooperate with HBX in a pathway to HCC that bypasses cirrhosis.

Original language	English (US)
Pages (from-to)	46-51
Number of pages	6
Journal	Cancer Letters
Volume	331
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2012.11.012
State	Published - Apr 30 2013

Keywords

HBX
Hepatitis B virus
Hepatocellularcarcinoma
R249S

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2012.11.012

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Ortiz-Cuaran, S., Villar, S., Gouas, D., Ferro, G., Plymoth, A., Khuhaprema, T., Kalalak, A., Sangrajrang, S., Friesen, M. D., Groopman, J. D., & Hainaut, P. (2013). Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand. Cancer Letters, 331(1), 46-51. https://doi.org/10.1016/j.canlet.2012.11.012

Ortiz-Cuaran, S, Villar, S, Gouas, D, Ferro, G, Plymoth, A, Khuhaprema, T, Kalalak, A, Sangrajrang, S, Friesen, MD, Groopman, JD & Hainaut, P 2013, 'Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand', Cancer Letters, vol. 331, no. 1, pp. 46-51. https://doi.org/10.1016/j.canlet.2012.11.012

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title = "Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand",

abstract = "Hepatocellular carcinoma (HCC) is associated with hepatitis B virus (HBV) chronicity and dietary exposure to aflatoxin, a mutagen targeting codon 249 of tumor suppressor TP53 (R249S mutation). Based on a case-control in Thailand, we have measured R249S and the status of HBX gene in plasma DNA of 176 cases and 133 referents. Detection of HBX complete sequences was associated with R249S in HCC with no documented prior cirrhosis but not in HCC developing in a context of cirrhosis or in non-cancer chronic liver diseases. Thus, R249S may specifically cooperate with HBX in a pathway to HCC that bypasses cirrhosis.",

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author = "Sandra Ortiz-Cuaran and Stephanie Villar and Doriane Gouas and Gilles Ferro and Amelie Plymoth and Thiravud Khuhaprema and Anant Kalalak and Suleeporn Sangrajrang and Friesen, {Marlin D.} and Groopman, {John D.} and Pierre Hainaut",

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AU - Ortiz-Cuaran, Sandra

AU - Villar, Stephanie

AU - Gouas, Doriane

AU - Ferro, Gilles

AU - Plymoth, Amelie

AU - Khuhaprema, Thiravud

AU - Kalalak, Anant

AU - Sangrajrang, Suleeporn

AU - Friesen, Marlin D.

AU - Groopman, John D.

AU - Hainaut, Pierre

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KW - Hepatocellularcarcinoma

KW - R249S

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Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand

Abstract

Keywords

ASJC Scopus subject areas

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