Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand

Sandra Ortiz-Cuaran, Stephanie Villar, Doriane Gouas, Gilles Ferro, Amelie Plymoth, Thiravud Khuhaprema, Anant Kalalak, Suleeporn Sangrajrang, Marlin D. Friesen, John D. Groopman, Pierre Hainaut

Research output: Contribution to journalArticle

Abstract

Hepatocellular carcinoma (HCC) is associated with hepatitis B virus (HBV) chronicity and dietary exposure to aflatoxin, a mutagen targeting codon 249 of tumor suppressor TP53 (R249S mutation). Based on a case-control in Thailand, we have measured R249S and the status of HBX gene in plasma DNA of 176 cases and 133 referents. Detection of HBX complete sequences was associated with R249S in HCC with no documented prior cirrhosis but not in HCC developing in a context of cirrhosis or in non-cancer chronic liver diseases. Thus, R249S may specifically cooperate with HBX in a pathway to HCC that bypasses cirrhosis.

Original languageEnglish (US)
Pages (from-to)46-51
Number of pages6
JournalCancer Letters
Volume331
Issue number1
DOIs
StatePublished - Apr 30 2013

Keywords

  • HBX
  • Hepatitis B virus
  • Hepatocellularcarcinoma
  • R249S

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand'. Together they form a unique fingerprint.

  • Cite this

    Ortiz-Cuaran, S., Villar, S., Gouas, D., Ferro, G., Plymoth, A., Khuhaprema, T., Kalalak, A., Sangrajrang, S., Friesen, M. D., Groopman, J. D., & Hainaut, P. (2013). Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand. Cancer Letters, 331(1), 46-51. https://doi.org/10.1016/j.canlet.2012.11.012