Association between genetic variants in the 8q24 cancer risk regions and circulating levels of androgens and sex hormone-binding globulin

Lisa W. Chu, Tamra E. Meyer, Qizhai Li, Idan Menashe, Kai Yu, Philip S. Rosenberg, Wen Yi Huang, Sabah M. Quraishi, Rudolf Kaaks, Jocelyn M. Weiss, Richard B. Hayes, Stephen J. Chanock, Ann W. Hsing

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: Genome-wide association studies have identified multiple independent regions on chromosome 8q24 that are associated with cancers of the prostate, breast, colon, and bladder. Methods: To investigate their biological basis, we examined the possible association between 164 single nucleotide polymorphisms (SNPs) in the 8q24 risk regions spanning 128,101,433-128,828,043 bp, and serum androgen (testosterone, androstenedione, 3αdiol G, and bioavailable testosterone), and sex hormone-binding globulin levels in 563 healthy, non-Hispanic, Caucasian men (55-74 years old) from a prospective cohort study (the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial). Age-adjusted linear regression models were used to determine the association between the SNPs in an additive genetic model and log-transformed biomarker levels. Results: Three adjacent SNPs centromeric to prostate cancer risk-region 2 (rs12334903, rs1456310, and rs980171) were associated with testosterone (P < 1.1 × 10-3) and bioavailable testosterone (P < 6.3 × 10-4). Suggestive associations were seen for a cluster of nine SNPs in prostate cancer risk region 1 and androstenedione (P < 0.05). Conclusions: These preliminary findings require confirmation in larger studies but raise the intriguing hypothesis that genetic variations in the 8q24 cancer risk regions might correlate with androgen levels. Impact: These results might provide some clues for the strong link between 8q24 and prostate cancer risk.

Original languageEnglish (US)
Pages (from-to)1848-1854
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume19
Issue number7
DOIs
StatePublished - Jul 2010
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

Fingerprint

Dive into the research topics of 'Association between genetic variants in the 8q24 cancer risk regions and circulating levels of androgens and sex hormone-binding globulin'. Together they form a unique fingerprint.

Cite this