Association between GABA-A receptor alpha 5 subunit gene locus and schizophrenia of a later age of onset

George Papadimitriou, Dimitris Dikeos, Eugenia Daskalopoulou, Georgia Karadima, Dimitrios Avramopoulos, Costas Contis, Costas Stefanis

Research output: Contribution to journalArticle

Abstract

Heritability is considered to be a major etiologic factor for schizophrenia. Among the genes considered as candidates for the disease, are those related to GABAergic neurotransmission. Our aim was to test for a genetic association between GABA-A receptor alpha 5 subunit gene locus (GABRA5) and schizophrenia. Genotyping of the GABRA5 locus was performed by the use of a dinucleotide (CA) repeat marker in 46 schizophrenic patients and 50 healthy individuals, all unrelated Greeks. Eight alleles were identified, 276-290 bp long. A nonsignificant excess of the 282-bp allele, which was found in a previous study in a Greek population to be associated with bipolar affective disorder, was observed in schizophrenic patients (33.8 vs. 23.9% in the controls). The frequency of this allele was 43.3% among patients with a later age of onset (over 25 years), differing at a statistically significant level from the controls (p < 0.05). These results suggest that common pathophysiological mechanisms may possibly underlie affective disorders and schizophrenia, at least in a subgroup of patients.

Original languageEnglish (US)
Pages (from-to)141-144
Number of pages4
JournalNeuropsychobiology
Volume43
Issue number3
DOIs
StatePublished - Apr 17 2001
Externally publishedYes

Keywords

  • GABA-A receptor alpha 5 subunit gene
  • Schizophrenia, age of onset
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

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    Papadimitriou, G., Dikeos, D., Daskalopoulou, E., Karadima, G., Avramopoulos, D., Contis, C., & Stefanis, C. (2001). Association between GABA-A receptor alpha 5 subunit gene locus and schizophrenia of a later age of onset. Neuropsychobiology, 43(3), 141-144. https://doi.org/10.1159/000054882