Association between family history of affective disorder and the depressive syndrome of alzheimer's disease

Godfrey D. Pearlson, Christopher A Ross, W. David Lohr, Barry W. Rovner, Gary A. Chase, Marshal F. Folstein

Research output: Contribution to journalArticle

Abstract

For each of 41 index patients with probable Alzheimer's disease and a first episode of major depression and 71 nondepressed Alzheimer's disease patients, two first-degree relatives were interviewed by a rater blind to presence or absence of depression in the proband. The depressed patients had significantly more first- and second-degree relatives with depression than did control subjects. The lifetime risk for major depression, adjusted for differences in age distribution, was significantly greater in first-degree relatives of index patients, suggesting that depression in Alzheimer's disease is genetically related to primary affective disorder. Alzheimer's disease may be useful for studying aspects of depressive pathophysiology.

Original languageEnglish (US)
Pages (from-to)452-456
Number of pages5
JournalAmerican Journal of Psychiatry
Volume147
Issue number4
StatePublished - 1990

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Depressive Disorder
Mood Disorders
Alzheimer Disease
Depression
Age Distribution

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Association between family history of affective disorder and the depressive syndrome of alzheimer's disease. / Pearlson, Godfrey D.; Ross, Christopher A; David Lohr, W.; Rovner, Barry W.; Chase, Gary A.; Folstein, Marshal F.

In: American Journal of Psychiatry, Vol. 147, No. 4, 1990, p. 452-456.

Research output: Contribution to journalArticle

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