Abstract
Objective: Inflammatory markers may be associated with breast cancer risk. We assessed the association between expression levels of proinflammatory (interleukin 6, tumor necrosis factor-α, C-reactive protein, cyclo-oxygenase 2, leptin, serum amyloid A1, interleukin 8, and signal transducer and activator of transcription 3) and anti-inflammatory markers (transforming growth factor-β, interleukin 10, and lactoferrin) in normal breast tissue with mammographic density, a strong breast cancer risk indicator, among 163 breast cancer patients. Methods: The expression of inflammatory markers was visually evaluated on immunohistochemistry stained slides. The percent mammographic density (PMD) was estimated by a computer-assisted method in the contralateral cancer-free breast. We used generalized linear models to estimate means of PMD by median expression levels of the inflammatory markers while adjusting for age and waist circumference. Results: Higher expression levels (above median) of the proinflammatory marker interleukin 6 were associated with higher PMD among all women (24.1% vs 18.5%, P = 0.007). Similarly, higher expression levels (above median) of the proinflammatory markers (interleukin 6, tumor necrosis factor-a, C-reactive protein, and interleukin 8) were associated with higher PMD among premenopausal women (absolute difference in the PMD of 8.8% [P= 0.006], 7.7% [P = 0.022], 6.7% [P = 0.037], and 16.5% [P = 0.032], respectively). Higher expression levels (above median) of the anti-inflammatory marker transforming growth factor-b were associated with lower PMD among all (18.8% vs 24.3%, P=0.005) and postmenopausal women (14.5% vs 20.7%, P=0.013). Conclusions: Our results provide support for the hypothesized role of inflammatory markers in breast carcinogenesis through their effects on mammographic density. Inflammatory markers could be targeted in future breast cancer prevention interventions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 524-535 |
| Number of pages | 12 |
| Journal | Menopause |
| Volume | 24 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 2017 |
| Externally published | Yes |
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Keywords
- Breast cancer risk
- Inflammatory markers
- Mammographic density
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Association between expression of inflammatory markers in normal breast tissue and mammographic density among premenopausal and postmenopausal women. / Hanna, Mirette; Dumas, Isabelle; Orain, Michèle; Jacob, Simon; Têtu, Bernard; Sanschagrin, François; Bureau, Alexandre; Poirier, Brigitte; Diorio, Caroline.
In: Menopause, Vol. 24, No. 5, 01.01.2017, p. 524-535.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between expression of inflammatory markers in normal breast tissue and mammographic density among premenopausal and postmenopausal women
AU - Hanna, Mirette
AU - Dumas, Isabelle
AU - Orain, Michèle
AU - Jacob, Simon
AU - Têtu, Bernard
AU - Sanschagrin, François
AU - Bureau, Alexandre
AU - Poirier, Brigitte
AU - Diorio, Caroline
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objective: Inflammatory markers may be associated with breast cancer risk. We assessed the association between expression levels of proinflammatory (interleukin 6, tumor necrosis factor-α, C-reactive protein, cyclo-oxygenase 2, leptin, serum amyloid A1, interleukin 8, and signal transducer and activator of transcription 3) and anti-inflammatory markers (transforming growth factor-β, interleukin 10, and lactoferrin) in normal breast tissue with mammographic density, a strong breast cancer risk indicator, among 163 breast cancer patients. Methods: The expression of inflammatory markers was visually evaluated on immunohistochemistry stained slides. The percent mammographic density (PMD) was estimated by a computer-assisted method in the contralateral cancer-free breast. We used generalized linear models to estimate means of PMD by median expression levels of the inflammatory markers while adjusting for age and waist circumference. Results: Higher expression levels (above median) of the proinflammatory marker interleukin 6 were associated with higher PMD among all women (24.1% vs 18.5%, P = 0.007). Similarly, higher expression levels (above median) of the proinflammatory markers (interleukin 6, tumor necrosis factor-a, C-reactive protein, and interleukin 8) were associated with higher PMD among premenopausal women (absolute difference in the PMD of 8.8% [P= 0.006], 7.7% [P = 0.022], 6.7% [P = 0.037], and 16.5% [P = 0.032], respectively). Higher expression levels (above median) of the anti-inflammatory marker transforming growth factor-b were associated with lower PMD among all (18.8% vs 24.3%, P=0.005) and postmenopausal women (14.5% vs 20.7%, P=0.013). Conclusions: Our results provide support for the hypothesized role of inflammatory markers in breast carcinogenesis through their effects on mammographic density. Inflammatory markers could be targeted in future breast cancer prevention interventions.
AB - Objective: Inflammatory markers may be associated with breast cancer risk. We assessed the association between expression levels of proinflammatory (interleukin 6, tumor necrosis factor-α, C-reactive protein, cyclo-oxygenase 2, leptin, serum amyloid A1, interleukin 8, and signal transducer and activator of transcription 3) and anti-inflammatory markers (transforming growth factor-β, interleukin 10, and lactoferrin) in normal breast tissue with mammographic density, a strong breast cancer risk indicator, among 163 breast cancer patients. Methods: The expression of inflammatory markers was visually evaluated on immunohistochemistry stained slides. The percent mammographic density (PMD) was estimated by a computer-assisted method in the contralateral cancer-free breast. We used generalized linear models to estimate means of PMD by median expression levels of the inflammatory markers while adjusting for age and waist circumference. Results: Higher expression levels (above median) of the proinflammatory marker interleukin 6 were associated with higher PMD among all women (24.1% vs 18.5%, P = 0.007). Similarly, higher expression levels (above median) of the proinflammatory markers (interleukin 6, tumor necrosis factor-a, C-reactive protein, and interleukin 8) were associated with higher PMD among premenopausal women (absolute difference in the PMD of 8.8% [P= 0.006], 7.7% [P = 0.022], 6.7% [P = 0.037], and 16.5% [P = 0.032], respectively). Higher expression levels (above median) of the anti-inflammatory marker transforming growth factor-b were associated with lower PMD among all (18.8% vs 24.3%, P=0.005) and postmenopausal women (14.5% vs 20.7%, P=0.013). Conclusions: Our results provide support for the hypothesized role of inflammatory markers in breast carcinogenesis through their effects on mammographic density. Inflammatory markers could be targeted in future breast cancer prevention interventions.
KW - Breast cancer risk
KW - Inflammatory markers
KW - Mammographic density
UR - http://www.scopus.com/inward/record.url?scp=85007240649&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85007240649&partnerID=8YFLogxK
U2 - 10.1097/GME.0000000000000794
DO - 10.1097/GME.0000000000000794
M3 - Article
C2 - 28002200
AN - SCOPUS:85007240649
VL - 24
SP - 524
EP - 535
JO - Menopause
JF - Menopause
SN - 1072-3714
IS - 5
ER -