Association between expression of glutathione-associated enzymes and response to platinum-based chemotherapy in head and neck cancer

Toshiro Nishimura, Kenneth Newkirk, Roy B. Sessions, Paul A. Andrews, Bruce J. Trock, Audrey A. Rusmussen, Elizabeth A. Montogomery, Elizabeth K. Bischoff, Marie H. Hanigan, Kevin J. Cullen

Research output: Contribution to journalArticle

Abstract

We examined the correlation between response to platinum-based chemotherapy and expression of glutathione S-transferase (GST), γ-GGT (both by immunohistochemistry) and γ-GCS (by in situ hybridization) in 51 patients with head and neck cancer, who received a total of 56 courses of chemotherapy. The overall response rate for the 56 chemotherapy treatment courses was 48%. The overall response rate (CR, PR) for patients with low GST scores was 88% (21 of 24), while among the patients with high GST scores, the overall response rate was 19% (6 of 32, P=0.001). Patients with a low GST score were 4.7 times more likely to respond to chemotherapy than patients with high GST scores. GST scores corresponded to response in 84% of cases. Among 33 patients treated with chemotherapy for relapsed disease, the overall response rate for patients with low GST score was 70% (7 of 10), while among the patients with high GST scores, the overall response rate was 8.7% (2 of 23, P<0.001). In contrast, both γ-GCS and γ-GGT showed a range of expression in these samples, but there was no significant correlation with treatment response. We conclude that GST expression correlates well with response to platinum based chemotherapy in head and neck cancer. Copyright (C) 1998 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)187-198
Number of pages12
JournalChemico-Biological Interactions
Volume111-112
DOIs
StatePublished - Apr 24 1998
Externally publishedYes

Keywords

  • Cancer
  • Glutathione-associated enzymes
  • Platinum-based chemotherapy

ASJC Scopus subject areas

  • Toxicology

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  • Cite this

    Nishimura, T., Newkirk, K., Sessions, R. B., Andrews, P. A., Trock, B. J., Rusmussen, A. A., Montogomery, E. A., Bischoff, E. K., Hanigan, M. H., & Cullen, K. J. (1998). Association between expression of glutathione-associated enzymes and response to platinum-based chemotherapy in head and neck cancer. Chemico-Biological Interactions, 111-112, 187-198. https://doi.org/10.1016/S0009-2797(97)00161-0