Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis

Rohit Loomba, Maria Abraham, Aynur Unalp, Laura Wilson, Joel Lavine, Ed Doo, Nathan M. Bass

Research output: Contribution to journalArticle

Abstract

Previous studies have shown familial aggregation of insulin resistance and nonalcoholic fatty liver disease (NAFLD). Therefore, we aimed to examine whether family history of diabetes mellitus (DM) is associated with nonalcoholic steatohepatitis (NASH) and fibrosis in patients with NAFLD. This was a cross-sectional analysis in participants of the NAFLD Database study and PIVENS trial who had available data on family history of DM. One thousand and sixty-nine patients (63% women), with mean age of 49.6 (± 11.8) years and body mass index (BMI) of 34.2 (± 6.4) kg/m2, were included. Thirty percent had DM, and 56% had a family history of DM. Both personal history of DM and family history of DM were significantly associated with NASH, with an odds ratio (OR) of 1.93 (95% confidence interval [CI]: 1.37-2.73; P

Original languageEnglish (US)
Pages (from-to)943-951
Number of pages9
JournalHepatology
Volume56
Issue number3
DOIs
StatePublished - Sep 2012

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Diabetes Mellitus
Fibrosis
Insulin Resistance
Non-alcoholic Fatty Liver Disease
Body Mass Index
Cross-Sectional Studies
Odds Ratio
Databases
Confidence Intervals

ASJC Scopus subject areas

  • Hepatology

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Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis. / Loomba, Rohit; Abraham, Maria; Unalp, Aynur; Wilson, Laura; Lavine, Joel; Doo, Ed; Bass, Nathan M.

In: Hepatology, Vol. 56, No. 3, 09.2012, p. 943-951.

Research output: Contribution to journalArticle

Loomba, Rohit ; Abraham, Maria ; Unalp, Aynur ; Wilson, Laura ; Lavine, Joel ; Doo, Ed ; Bass, Nathan M. / Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis. In: Hepatology. 2012 ; Vol. 56, No. 3. pp. 943-951.
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