Association between Cytomegalovirus antibody levels and cognitive functioning in non-elderly adults

Faith Dickerson, Cassie Stallings, Andrea Origoni, Emily Katsafanas, Lucy A B Schweinfurth, Christina L G Savage, Robert H Yolken

Research output: Contribution to journalArticle

Abstract

Background: Elevated levels of antibodies to Cytomegalovirus (CMV) have been associated with cognitive impairment, but the quantitative relationship between CMV antibody levels and domains of cognitive functioning in younger adults has not been established. Methods: We measured IgG class antibodies to Cytomegalovirus in 521 individuals, mean age 32.8 years. Participants were selected for the absence of psychiatric disorder and of a serious medical condition that could affect brain functioning. Cognitive functioning was measured with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), the Wisconsin Card Sorting Test, Trail Making Test part A, and the WAIS III Letter Number Sequencing subtest. Linear regression analyses were used to measure the quantitative association between cognitive scores and Cytomegalovirus IgG antibody level. Logistic regression analyses were used to measure the odds of low cognitive scores and elevated antibody levels defined as an antibody level > = 50th, 75th, and 90th percentile of the group. Results: Higher levels of CMV antibodies were associated with lower performance on RBANS Total (coefficient -1.03, p-7), and Letter Number Sequencing (coefficient -0.15, pth % CI 1.01, 2.64; pth % CI 1.33, 3.70; pth % CI 1.24, 4.86; pth, 75 th, and 90th percentile respectively. Conclusions: Higher levels of Cytomegalovirus antibodies are associated with lower levels of cognitive functioning in nonelderly adults. Methods for the prevention and treatment of CMV infection should be evaluated to determine if they result in an improvement in cognitive functioning in otherwise healthy adults.

Original languageEnglish (US)
Article numbere95510
JournalPLoS One
Volume9
Issue number5
DOIs
StatePublished - May 20 2014

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Cytomegalovirus
antibodies
Antibodies
Immunoglobulin G
Regression Analysis
Trail Making Test
Immunoglobulin Isotypes
Cytomegalovirus Infections
behavior disorders
Sorting
Linear regression
Psychiatry
Logistics
young adults
Young Adult
Linear Models
Brain
sorting
Logistic Models
testing

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Dickerson, F., Stallings, C., Origoni, A., Katsafanas, E., Schweinfurth, L. A. B., Savage, C. L. G., & Yolken, R. H. (2014). Association between Cytomegalovirus antibody levels and cognitive functioning in non-elderly adults. PLoS One, 9(5), [e95510]. https://doi.org/10.1371/journal.pone.0095510

Association between Cytomegalovirus antibody levels and cognitive functioning in non-elderly adults. / Dickerson, Faith; Stallings, Cassie; Origoni, Andrea; Katsafanas, Emily; Schweinfurth, Lucy A B; Savage, Christina L G; Yolken, Robert H.

In: PLoS One, Vol. 9, No. 5, e95510, 20.05.2014.

Research output: Contribution to journalArticle

Dickerson, F, Stallings, C, Origoni, A, Katsafanas, E, Schweinfurth, LAB, Savage, CLG & Yolken, RH 2014, 'Association between Cytomegalovirus antibody levels and cognitive functioning in non-elderly adults', PLoS One, vol. 9, no. 5, e95510. https://doi.org/10.1371/journal.pone.0095510
Dickerson F, Stallings C, Origoni A, Katsafanas E, Schweinfurth LAB, Savage CLG et al. Association between Cytomegalovirus antibody levels and cognitive functioning in non-elderly adults. PLoS One. 2014 May 20;9(5). e95510. https://doi.org/10.1371/journal.pone.0095510
Dickerson, Faith ; Stallings, Cassie ; Origoni, Andrea ; Katsafanas, Emily ; Schweinfurth, Lucy A B ; Savage, Christina L G ; Yolken, Robert H. / Association between Cytomegalovirus antibody levels and cognitive functioning in non-elderly adults. In: PLoS One. 2014 ; Vol. 9, No. 5.
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abstract = "Background: Elevated levels of antibodies to Cytomegalovirus (CMV) have been associated with cognitive impairment, but the quantitative relationship between CMV antibody levels and domains of cognitive functioning in younger adults has not been established. Methods: We measured IgG class antibodies to Cytomegalovirus in 521 individuals, mean age 32.8 years. Participants were selected for the absence of psychiatric disorder and of a serious medical condition that could affect brain functioning. Cognitive functioning was measured with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), the Wisconsin Card Sorting Test, Trail Making Test part A, and the WAIS III Letter Number Sequencing subtest. Linear regression analyses were used to measure the quantitative association between cognitive scores and Cytomegalovirus IgG antibody level. Logistic regression analyses were used to measure the odds of low cognitive scores and elevated antibody levels defined as an antibody level > = 50th, 75th, and 90th percentile of the group. Results: Higher levels of CMV antibodies were associated with lower performance on RBANS Total (coefficient -1.03, p-7), and Letter Number Sequencing (coefficient -0.15, pth {\%} CI 1.01, 2.64; pth {\%} CI 1.33, 3.70; pth {\%} CI 1.24, 4.86; pth, 75 th, and 90th percentile respectively. Conclusions: Higher levels of Cytomegalovirus antibodies are associated with lower levels of cognitive functioning in nonelderly adults. Methods for the prevention and treatment of CMV infection should be evaluated to determine if they result in an improvement in cognitive functioning in otherwise healthy adults.",
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