TY - JOUR
T1 - Association between combined interleukin-6 and c-reactive protein levels and pulmonary function in older women
T2 - Results from the women's health and aging studies i and II
AU - Chang, Sandy S.
AU - Vaz Fragoso, Carlos A.
AU - Van Ness, Peter H.
AU - Fried, Linda P.
AU - Tinetti, Mary E.
PY - 2011/1
Y1 - 2011/1
N2 - OBJECTIVES: To determine whether combined higher interleukin-6 (IL-6) and C-reactive protein (CRP) levels are associated with lower pulmonary function levels in older women, accounting for chronic inflammatory diseases, physical function, and other factors associated with inflammation. DESIGN: Cross-sectional study using data from two prospective cohorts. SETTING: Baltimore, Maryland. PARTICIPANTS: Eight hundred forty disabled and 332 higher-functioning community-dwelling women aged 65 and older from the Women's Health and Aging Studies (WHAS) I and II, respectively. MEASUREMENTS: IL-6 and CRP, combined according to their tertile concentrations, and pulmonary function measures, assessed according to forced expiratory volume in 1 second (FEV 1) and forced vital capacity (FVC). RESULTS: In WHAS I and II, similar dose-response trends were observed between combined higher IL-6 and CRP levels and lower pulmonary function levels. In WHAS I (disabled women), the combined highest IL-6 and CRP levels were associated with the lowest levels of FEV1 (mean 137.0 mL, 95% confidence interval (CI)=128.4-145.7 mL) and FVC (mean 191.7 mL, 95% CI=180.4-202.9 mL). Similarly, in WHAS II (higher-functioning women), the combined highest IL-6 and CRP levels were associated with the lowest levels of FEV1 (mean 158.3 mL, 95% CI=146.3-170.4 mL) and FVC (mean 224.2 mL, 95% CI=209.9-238.5 mL). CONCLUSION: Combined elevations in IL-6 and CRP were associated with the lowest pulmonary function levels in older women. These findings suggest that high IL-6 and CRP levels may be an indication of prevalent impaired pulmonary function. Future studies should determine whether measurement of IL-6 and CRP could enhance current methods of monitoring respiratory diseases beyond that provided by pulmonary function measures.
AB - OBJECTIVES: To determine whether combined higher interleukin-6 (IL-6) and C-reactive protein (CRP) levels are associated with lower pulmonary function levels in older women, accounting for chronic inflammatory diseases, physical function, and other factors associated with inflammation. DESIGN: Cross-sectional study using data from two prospective cohorts. SETTING: Baltimore, Maryland. PARTICIPANTS: Eight hundred forty disabled and 332 higher-functioning community-dwelling women aged 65 and older from the Women's Health and Aging Studies (WHAS) I and II, respectively. MEASUREMENTS: IL-6 and CRP, combined according to their tertile concentrations, and pulmonary function measures, assessed according to forced expiratory volume in 1 second (FEV 1) and forced vital capacity (FVC). RESULTS: In WHAS I and II, similar dose-response trends were observed between combined higher IL-6 and CRP levels and lower pulmonary function levels. In WHAS I (disabled women), the combined highest IL-6 and CRP levels were associated with the lowest levels of FEV1 (mean 137.0 mL, 95% confidence interval (CI)=128.4-145.7 mL) and FVC (mean 191.7 mL, 95% CI=180.4-202.9 mL). Similarly, in WHAS II (higher-functioning women), the combined highest IL-6 and CRP levels were associated with the lowest levels of FEV1 (mean 158.3 mL, 95% CI=146.3-170.4 mL) and FVC (mean 224.2 mL, 95% CI=209.9-238.5 mL). CONCLUSION: Combined elevations in IL-6 and CRP were associated with the lowest pulmonary function levels in older women. These findings suggest that high IL-6 and CRP levels may be an indication of prevalent impaired pulmonary function. Future studies should determine whether measurement of IL-6 and CRP could enhance current methods of monitoring respiratory diseases beyond that provided by pulmonary function measures.
KW - inflammation
KW - older women
KW - pulmonary function
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U2 - 10.1111/j.1532-5415.2010.03203.x
DO - 10.1111/j.1532-5415.2010.03203.x
M3 - Article
C2 - 21226682
AN - SCOPUS:78651384902
SN - 0002-8614
VL - 59
SP - 113
EP - 119
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 1
ER -