TY - JOUR
T1 - Association between colonization with group B streptococci during pregnancy and preterm delivery among Danish women
AU - Feikin, Daniel R.
AU - Thorsen, Poul
AU - Zywicki, Sara
AU - Arpi, Magnus
AU - Westergaard, Jes G.
AU - Schuchat, Anne
N1 - Funding Information:
Supported by the Danish Health Insurance Foundation; the Institute of Clinical Research, University of Odense; the Foundation of Reproductive Biology, Odense University Hospital; the National Fund for Research and Development; the Danish Ministry of Health; the Medical-Scientific Foundation for Copenhagen, the Faeroe Islands, and Greenland; the Merchant Sven Hansen and Mrs. Ina Hansen Foundation; the Director Jacob Madsen and Mrs. Olga Madsen Foundation; and the Nordic Union of Obstetricians and Gynaecologists Foundation, Odense University Hospital, Denmark. The activities of The Danish Epidemiology Science Centre were financed by a grant from The Danish National Research Foundation.
PY - 2001
Y1 - 2001
N2 - OBJECTIVE: We studied the relationship between group B streptococcal colonization and preterm delivery. STUDY DESIGN: In this prospective study at a single hospital in Odense, Denmark, cervicovaginal cultures were obtained at ≤24 weeks' gestation from all the women, at delivery from women with preterm deliveries, and from a random sample of women delivering at term. RESULTS: In 2846 singleton births, there was no significant association between group B streptococcal colonization at ≤24 weeks' gestation and preterm birth. After adjustment for the risk factors for preterm delivery, more women with preterm delivery (12/84, 14%) were colonized at delivery with group B streptococci than women with term deliveries (22/300, 7%; adjusted odds ratio, 3.0; 95% confidence interval, 1.4-6.8). Group B streptococcal colonization at ≤24 weeks' gestation and at delivery was significantly less likely to occur in the presence of normal vaginal flora. CONCLUSION: Group B streptococcal colonization at delivery, but not at ≤24 weeks' gestation, was associated with preterm delivery.
AB - OBJECTIVE: We studied the relationship between group B streptococcal colonization and preterm delivery. STUDY DESIGN: In this prospective study at a single hospital in Odense, Denmark, cervicovaginal cultures were obtained at ≤24 weeks' gestation from all the women, at delivery from women with preterm deliveries, and from a random sample of women delivering at term. RESULTS: In 2846 singleton births, there was no significant association between group B streptococcal colonization at ≤24 weeks' gestation and preterm birth. After adjustment for the risk factors for preterm delivery, more women with preterm delivery (12/84, 14%) were colonized at delivery with group B streptococci than women with term deliveries (22/300, 7%; adjusted odds ratio, 3.0; 95% confidence interval, 1.4-6.8). Group B streptococcal colonization at ≤24 weeks' gestation and at delivery was significantly less likely to occur in the presence of normal vaginal flora. CONCLUSION: Group B streptococcal colonization at delivery, but not at ≤24 weeks' gestation, was associated with preterm delivery.
KW - Group B streptococci
KW - Preterm delivery
KW - Vaginal colonization during pregnancy
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U2 - 10.1067/mob.2001.109936
DO - 10.1067/mob.2001.109936
M3 - Article
C2 - 11228498
AN - SCOPUS:0035092498
SN - 0002-9378
VL - 184
SP - 427
EP - 433
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 3
ER -