Association between colonization with group B streptococci during pregnancy and preterm delivery among Danish women

Daniel Feikin, Poul Thorsen, Sara Zywicki, Magnus Arpi, Jes G. Westergaard, Anne Schuchat

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: We studied the relationship between group B streptococcal colonization and preterm delivery. STUDY DESIGN: In this prospective study at a single hospital in Odense, Denmark, cervicovaginal cultures were obtained at ≤24 weeks' gestation from all the women, at delivery from women with preterm deliveries, and from a random sample of women delivering at term. RESULTS: In 2846 singleton births, there was no significant association between group B streptococcal colonization at ≤24 weeks' gestation and preterm birth. After adjustment for the risk factors for preterm delivery, more women with preterm delivery (12/84, 14%) were colonized at delivery with group B streptococci than women with term deliveries (22/300, 7%; adjusted odds ratio, 3.0; 95% confidence interval, 1.4-6.8). Group B streptococcal colonization at ≤24 weeks' gestation and at delivery was significantly less likely to occur in the presence of normal vaginal flora. CONCLUSION: Group B streptococcal colonization at delivery, but not at ≤24 weeks' gestation, was associated with preterm delivery.

Original languageEnglish (US)
Pages (from-to)427-433
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume184
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Streptococcus agalactiae
Pregnancy
Premature Birth
Denmark
Odds Ratio
Parturition
Prospective Studies
Confidence Intervals

Keywords

  • Group B streptococci
  • Preterm delivery
  • Vaginal colonization during pregnancy

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Association between colonization with group B streptococci during pregnancy and preterm delivery among Danish women. / Feikin, Daniel; Thorsen, Poul; Zywicki, Sara; Arpi, Magnus; Westergaard, Jes G.; Schuchat, Anne.

In: American Journal of Obstetrics and Gynecology, Vol. 184, No. 3, 2001, p. 427-433.

Research output: Contribution to journalArticle

Feikin, Daniel ; Thorsen, Poul ; Zywicki, Sara ; Arpi, Magnus ; Westergaard, Jes G. ; Schuchat, Anne. / Association between colonization with group B streptococci during pregnancy and preterm delivery among Danish women. In: American Journal of Obstetrics and Gynecology. 2001 ; Vol. 184, No. 3. pp. 427-433.
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