Association between chronic disseminated candidiasis in adult acute leukemia and common IL4 promoter haplotypes

Eun Hwa Choi, Charles B. Foster, James G. Taylor, Hans Christian Erichsen, Renee A. Chen, Thomas J. Walsh, Veli Jukka Anttila, Tapani Ruutu, Aarno Palotie, Stephen J. Chanock

Research output: Contribution to journalArticle

Abstract

Chronic disseminated candidiasis (CDC) is a form of Candida species infection observed primarily in patients with acute leukemia. To investigate possible genetic factors associated with CDC, we conducted a pilot study of 40 patients with both leukemia and CDC and 50 control patients with leukemia only. A common haplotype of the IL4 promoter (-1098T/-589C/-33C) was overrepresented in patients with CDC (P = .01; odds ratio [OR], 2.16), whereas another common haplotype (-1098T/-589T/-33T) appeared to be protective against CDC (P = .018; OR, 0.47). Genetic variants of IL4 could contribute to the development of CDC in patients with acute leukemia.

Original languageEnglish (US)
Pages (from-to)1153-1156
Number of pages4
JournalJournal of Infectious Diseases
Volume187
Issue number7
DOIs
StatePublished - Apr 1 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Choi, E. H., Foster, C. B., Taylor, J. G., Erichsen, H. C., Chen, R. A., Walsh, T. J., Anttila, V. J., Ruutu, T., Palotie, A., & Chanock, S. J. (2003). Association between chronic disseminated candidiasis in adult acute leukemia and common IL4 promoter haplotypes. Journal of Infectious Diseases, 187(7), 1153-1156. https://doi.org/10.1086/368345