Association between chronic disseminated candidiasis in adult acute leukemia and common IL4 promoter haplotypes

Eun Hwa Choi; Charles B. Foster; James G. Taylor; Hans Christian Erichsen; Renee A. Chen; Thomas J. Walsh; Veli Jukka Anttila; Tapani Ruutu; Aarno Palotie; Stephen J. Chanock

doi:10.1086/368345

Association between chronic disseminated candidiasis in adult acute leukemia and common IL4 promoter haplotypes

Eun Hwa Choi, Charles B. Foster, James G. Taylor, Hans Christian Erichsen, Renee A. Chen, Thomas J. Walsh, Veli Jukka Anttila, Tapani Ruutu, Aarno Palotie, Stephen J. Chanock

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42 Scopus citations

Abstract

Chronic disseminated candidiasis (CDC) is a form of Candida species infection observed primarily in patients with acute leukemia. To investigate possible genetic factors associated with CDC, we conducted a pilot study of 40 patients with both leukemia and CDC and 50 control patients with leukemia only. A common haplotype of the IL4 promoter (-1098T/-589C/-33C) was overrepresented in patients with CDC (P = .01; odds ratio [OR], 2.16), whereas another common haplotype (-1098T/-589T/-33T) appeared to be protective against CDC (P = .018; OR, 0.47). Genetic variants of IL4 could contribute to the development of CDC in patients with acute leukemia.

Original language	English (US)
Pages (from-to)	1153-1156
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	187
Issue number	7
DOIs	https://doi.org/10.1086/368345
State	Published - Apr 1 2003
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1086/368345

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title = "Association between chronic disseminated candidiasis in adult acute leukemia and common IL4 promoter haplotypes",

abstract = "Chronic disseminated candidiasis (CDC) is a form of Candida species infection observed primarily in patients with acute leukemia. To investigate possible genetic factors associated with CDC, we conducted a pilot study of 40 patients with both leukemia and CDC and 50 control patients with leukemia only. A common haplotype of the IL4 promoter (-1098T/-589C/-33C) was overrepresented in patients with CDC (P = .01; odds ratio [OR], 2.16), whereas another common haplotype (-1098T/-589T/-33T) appeared to be protective against CDC (P = .018; OR, 0.47). Genetic variants of IL4 could contribute to the development of CDC in patients with acute leukemia.",

author = "Choi, {Eun Hwa} and Foster, {Charles B.} and Taylor, {James G.} and Erichsen, {Hans Christian} and Chen, {Renee A.} and Walsh, {Thomas J.} and Anttila, {Veli Jukka} and Tapani Ruutu and Aarno Palotie and Chanock, {Stephen J.}",

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doi = "10.1086/368345",

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T1 - Association between chronic disseminated candidiasis in adult acute leukemia and common IL4 promoter haplotypes

AU - Choi, Eun Hwa

AU - Foster, Charles B.

AU - Taylor, James G.

AU - Erichsen, Hans Christian

AU - Chen, Renee A.

AU - Walsh, Thomas J.

AU - Anttila, Veli Jukka

AU - Ruutu, Tapani

AU - Palotie, Aarno

AU - Chanock, Stephen J.

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Chronic disseminated candidiasis (CDC) is a form of Candida species infection observed primarily in patients with acute leukemia. To investigate possible genetic factors associated with CDC, we conducted a pilot study of 40 patients with both leukemia and CDC and 50 control patients with leukemia only. A common haplotype of the IL4 promoter (-1098T/-589C/-33C) was overrepresented in patients with CDC (P = .01; odds ratio [OR], 2.16), whereas another common haplotype (-1098T/-589T/-33T) appeared to be protective against CDC (P = .018; OR, 0.47). Genetic variants of IL4 could contribute to the development of CDC in patients with acute leukemia.

AB - Chronic disseminated candidiasis (CDC) is a form of Candida species infection observed primarily in patients with acute leukemia. To investigate possible genetic factors associated with CDC, we conducted a pilot study of 40 patients with both leukemia and CDC and 50 control patients with leukemia only. A common haplotype of the IL4 promoter (-1098T/-589C/-33C) was overrepresented in patients with CDC (P = .01; odds ratio [OR], 2.16), whereas another common haplotype (-1098T/-589T/-33T) appeared to be protective against CDC (P = .018; OR, 0.47). Genetic variants of IL4 could contribute to the development of CDC in patients with acute leukemia.

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Association between chronic disseminated candidiasis in adult acute leukemia and common IL4 promoter haplotypes

Abstract

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