TY - JOUR
T1 - Association between central sleep apnea and left ventricular structure
T2 - the Multi-Ethnic Study of Atherosclerosis
AU - Javaheri, Sogol
AU - Sharma, Ravi K.
AU - Bluemke, David A.
AU - Redline, Susan
N1 - Funding Information:
NIH 5T32HL007901, 1R01HL083075, R01HL098433, R01 HL098433-02S1, 1U34HL105277-01, 1R01HL110068-01A1, 1R01HL113338-01, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168 and N01-HC-95169 from the National Heart, Lung, and Blood Institute and by grants UL1-TR-000040 and UL1-TR-001079 from NCRR.
Publisher Copyright:
© 2017 European Sleep Research Society
PY - 2017/8
Y1 - 2017/8
N2 - We assessed whether the presence of central sleep apnea is associated with adverse left ventricular structural changes. We analysed 1412 participants from the Multi-Ethnic Study of Atherosclerosis who underwent both overnight polysomnography and cardiac magnetic resonance imaging. Subjects had been recruited 10 years earlier when free of cardiovascular disease. Our main exposure is the presence of central sleep apnea as defined by central apnea–hypopnea index = 5 or the presence of Cheyne–Stokes breathing. Outcome variables were left ventricular mass/height, left ventricular ejection fraction, and left ventricular mass/volume ratio. Multivariate linear regression models adjusted for age, gender, race, waist circumference, tobacco use, hypertension, and the obstructive apnea–hypopnea index were fit for the outcomes. Of the 1412 participants, 27 (2%) individuals had central sleep apnea. After adjusting for covariates, the presence of central sleep apnea was significantly associated with elevated left ventricular mass/volume ratio (β = 0.11 ± 0.04 g mL−1, P = 0.0071), an adverse cardiac finding signifying concentric remodelling.
AB - We assessed whether the presence of central sleep apnea is associated with adverse left ventricular structural changes. We analysed 1412 participants from the Multi-Ethnic Study of Atherosclerosis who underwent both overnight polysomnography and cardiac magnetic resonance imaging. Subjects had been recruited 10 years earlier when free of cardiovascular disease. Our main exposure is the presence of central sleep apnea as defined by central apnea–hypopnea index = 5 or the presence of Cheyne–Stokes breathing. Outcome variables were left ventricular mass/height, left ventricular ejection fraction, and left ventricular mass/volume ratio. Multivariate linear regression models adjusted for age, gender, race, waist circumference, tobacco use, hypertension, and the obstructive apnea–hypopnea index were fit for the outcomes. Of the 1412 participants, 27 (2%) individuals had central sleep apnea. After adjusting for covariates, the presence of central sleep apnea was significantly associated with elevated left ventricular mass/volume ratio (β = 0.11 ± 0.04 g mL−1, P = 0.0071), an adverse cardiac finding signifying concentric remodelling.
KW - cardiac magnetic resonance imaging
KW - ejection fraction
KW - left ventricular mass
KW - left ventricular mass/volume ratio
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U2 - 10.1111/jsr.12501
DO - 10.1111/jsr.12501
M3 - Article
C2 - 28220556
AN - SCOPUS:85013432439
SN - 0962-1105
VL - 26
SP - 477
EP - 480
JO - Journal of Sleep Research
JF - Journal of Sleep Research
IS - 4
ER -