TY - JOUR
T1 - Association between BRAF V600E mutation and recurrence of papillary thyroid cancer
AU - Xing, Mingzhao
AU - Alzahrani, Ali S.
AU - Carson, Kathryn A.
AU - Shong, Young Kee
AU - Kim, Tae Yong
AU - Viola, David
AU - Elisei, Rossella
AU - Bendlová, Bela
AU - Yip, Linwah
AU - Mian, Caterina
AU - Vianello, Federica
AU - Tuttle, R. Michael
AU - Robenshtok, Eyal
AU - Fagin, James A.
AU - Puxeddu, Efisio
AU - Fugazzola, Laura
AU - Czarniecka, Agnieszka
AU - Jarzab, Barbara
AU - O'Neill, Christine J.
AU - Sywak, Mark S.
AU - Lam, Alfred K.
AU - Riesco-Eizaguirre, Garcilaso
AU - Santisteban, Pilar
AU - Nakayama, Hirotaka
AU - Clifton-Bligh, Roderick
AU - Tallini, Giovanni
AU - Holt, Elizabeth H.
AU - Sýkorová, Vlasta
N1 - Publisher Copyright:
© 2014 by American Society of Clinical Oncology.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Purpose: To investigate the prognostic value of BRAFV600E mutation for the recurrence of papillary thyroid cancer (PTC) Patients and Methods: This was a retrospective multicenter study of the relationship between BRAF V600E mutation and recurrence of PTC in 2,099 patients (1,615 women and 484 men), with a median age of 45 years (interquartile range [IQR], 34 to 58 years) and a median follow-up time of 36 months (IQR, 14 to 75 months) Results: The overall BRAF V600E mutation prevalence was 48.5% (1,017 of 2,099). PTC recurrence occurred in 20.9% (213 of 1,017) of BRAFV600E mutation-positive and 11.6% (125 of 1,082) of BRAFV600E mutation-negative patients. Recurrence rates were 47.71 (95% CI, 41.72 to 54.57) versus 26.03 (95% CI, 21.85 to 31.02) per 1,000 person-years in BRAF mutation-positive versus - Negative patients (P <.001), with a hazard ratio (HR) of 1.82 (95% CI, 1.46 to 2.28), which remained significant in a multivariable model adjusting for patient sex and age at diagnosis, medical center, and various conventional pathologic factors. Significant association between BRAF mutation and PTC recurrence was also found in patients with conventionally low-risk disease stage or II and micro-PTC and within various subtypes of PTC. For example, in BRAF mutation-positive versus - Negative follicular-variant PTC, recurrence occurred in 21.3% (19 of 89) and 7.0% (24 of 342) of patients, respectively, with recurrence rates of 53.84 (95% CI, 34.34 to 84.40) versus 19.47 (95% CI, 13.05 to 29.04) per 1,000 person-years (P <.001) and an HR of 3.20 (95% CI, 1.46 to 7.02) after adjustment for clinicopathologic factors. BRAF mutation was associated with poorer recurrence-free probability in Kaplan-Meier survival analyses in various clinicopathologic categories. Conclusion: This large multicenter study demonstrates an independent prognostic value of BRAF V600E mutation for PTC recurrence in various clinicopathologic categories.
AB - Purpose: To investigate the prognostic value of BRAFV600E mutation for the recurrence of papillary thyroid cancer (PTC) Patients and Methods: This was a retrospective multicenter study of the relationship between BRAF V600E mutation and recurrence of PTC in 2,099 patients (1,615 women and 484 men), with a median age of 45 years (interquartile range [IQR], 34 to 58 years) and a median follow-up time of 36 months (IQR, 14 to 75 months) Results: The overall BRAF V600E mutation prevalence was 48.5% (1,017 of 2,099). PTC recurrence occurred in 20.9% (213 of 1,017) of BRAFV600E mutation-positive and 11.6% (125 of 1,082) of BRAFV600E mutation-negative patients. Recurrence rates were 47.71 (95% CI, 41.72 to 54.57) versus 26.03 (95% CI, 21.85 to 31.02) per 1,000 person-years in BRAF mutation-positive versus - Negative patients (P <.001), with a hazard ratio (HR) of 1.82 (95% CI, 1.46 to 2.28), which remained significant in a multivariable model adjusting for patient sex and age at diagnosis, medical center, and various conventional pathologic factors. Significant association between BRAF mutation and PTC recurrence was also found in patients with conventionally low-risk disease stage or II and micro-PTC and within various subtypes of PTC. For example, in BRAF mutation-positive versus - Negative follicular-variant PTC, recurrence occurred in 21.3% (19 of 89) and 7.0% (24 of 342) of patients, respectively, with recurrence rates of 53.84 (95% CI, 34.34 to 84.40) versus 19.47 (95% CI, 13.05 to 29.04) per 1,000 person-years (P <.001) and an HR of 3.20 (95% CI, 1.46 to 7.02) after adjustment for clinicopathologic factors. BRAF mutation was associated with poorer recurrence-free probability in Kaplan-Meier survival analyses in various clinicopathologic categories. Conclusion: This large multicenter study demonstrates an independent prognostic value of BRAF V600E mutation for PTC recurrence in various clinicopathologic categories.
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U2 - 10.1200/JCO.2014.56.8253
DO - 10.1200/JCO.2014.56.8253
M3 - Article
C2 - 25332244
AN - SCOPUS:84920593838
SN - 0732-183X
VL - 33
SP - 42
EP - 50
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 1
ER -