Association between baseline fetal hemoglobin levels and incidence of severe vaso-occlusive pain episodes in children with sickle cell anemia

Pallav Bhatnagar, Jeffrey Keefer, James F Casella, Emily Barron-Casella, Christopher J. Bean, Craig W. Hooper, Amanda B. Payne, Dan Arking, Michael R. Debaun

Research output: Contribution to journalArticle


The ameliorating effect of high fetal hemoglobin (HbF) levels on the incidence of pain episodes in sickle cell anemia (SCA) is well-known; however, in children this relationship is less clearly established. We hypothesized that higher HbF levels in children with SCA are associated with fewer severe pain episodes. A meta-analysis of data from the Silent Infarct Transfusion Trial (n=456) and the Cooperative Study of Sickle Cell Disease (n=764), demonstrated that baseline HbF levels were associated with the incidence of severe pain, commonly defined across studies as an event requiring hospitalization (P-value=0.02). Pediatr Blood Cancer 2013;60:E125-E127.

Original languageEnglish (US)
JournalPediatric Blood and Cancer
Issue number10
StatePublished - Oct 2013



  • Fetal hemoglobin
  • Sickle cell anemia
  • Vaso-occlusive pain

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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