Association between baseline fetal hemoglobin levels and incidence of severe vaso-occlusive pain episodes in children with sickle cell anemia

Pallav Bhatnagar; Jeffrey R. Keefer; James F. Casella; Emily A. Barron-Casella; Christopher J. Bean; Craig W. Hooper; Amanda B. Payne; Dan E. Arking; Michael R. Debaun

doi:10.1002/pbc.24588

Association between baseline fetal hemoglobin levels and incidence of severe vaso-occlusive pain episodes in children with sickle cell anemia

Pallav Bhatnagar, Jeffrey R. Keefer, James F. Casella, Emily A. Barron-Casella, Christopher J. Bean, Craig W. Hooper, Amanda B. Payne, Dan E. Arking, Michael R. Debaun

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The ameliorating effect of high fetal hemoglobin (HbF) levels on the incidence of pain episodes in sickle cell anemia (SCA) is well-known; however, in children this relationship is less clearly established. We hypothesized that higher HbF levels in children with SCA are associated with fewer severe pain episodes. A meta-analysis of data from the Silent Infarct Transfusion Trial (n=456) and the Cooperative Study of Sickle Cell Disease (n=764), demonstrated that baseline HbF levels were associated with the incidence of severe pain, commonly defined across studies as an event requiring hospitalization (P-value=0.02). Pediatr Blood Cancer 2013;60:E125-E127.

Original language	English (US)
Pages (from-to)	E125-E127
Journal	Pediatric Blood and Cancer
Volume	60
Issue number	10
DOIs	https://doi.org/10.1002/pbc.24588
State	Published - Oct 2013

Keywords

Fetal hemoglobin
Sickle cell anemia
Vaso-occlusive pain

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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Bhatnagar, P., Keefer, J. R., Casella, J. F., Barron-Casella, E. A., Bean, C. J., Hooper, C. W., Payne, A. B., Arking, D. E., & Debaun, M. R. (2013). Association between baseline fetal hemoglobin levels and incidence of severe vaso-occlusive pain episodes in children with sickle cell anemia. Pediatric Blood and Cancer, 60(10), E125-E127. https://doi.org/10.1002/pbc.24588

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abstract = "The ameliorating effect of high fetal hemoglobin (HbF) levels on the incidence of pain episodes in sickle cell anemia (SCA) is well-known; however, in children this relationship is less clearly established. We hypothesized that higher HbF levels in children with SCA are associated with fewer severe pain episodes. A meta-analysis of data from the Silent Infarct Transfusion Trial (n=456) and the Cooperative Study of Sickle Cell Disease (n=764), demonstrated that baseline HbF levels were associated with the incidence of severe pain, commonly defined across studies as an event requiring hospitalization (P-value=0.02). Pediatr Blood Cancer 2013;60:E125-E127.",

keywords = "Fetal hemoglobin, Sickle cell anemia, Vaso-occlusive pain",

author = "Pallav Bhatnagar and Keefer, {Jeffrey R.} and Casella, {James F.} and Barron-Casella, {Emily A.} and Bean, {Christopher J.} and Hooper, {Craig W.} and Payne, {Amanda B.} and Arking, {Dan E.} and Debaun, {Michael R.}",

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AU - Bhatnagar, Pallav

AU - Keefer, Jeffrey R.

AU - Casella, James F.

AU - Barron-Casella, Emily A.

AU - Bean, Christopher J.

AU - Hooper, Craig W.

AU - Payne, Amanda B.

AU - Arking, Dan E.

AU - Debaun, Michael R.

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AB - The ameliorating effect of high fetal hemoglobin (HbF) levels on the incidence of pain episodes in sickle cell anemia (SCA) is well-known; however, in children this relationship is less clearly established. We hypothesized that higher HbF levels in children with SCA are associated with fewer severe pain episodes. A meta-analysis of data from the Silent Infarct Transfusion Trial (n=456) and the Cooperative Study of Sickle Cell Disease (n=764), demonstrated that baseline HbF levels were associated with the incidence of severe pain, commonly defined across studies as an event requiring hospitalization (P-value=0.02). Pediatr Blood Cancer 2013;60:E125-E127.

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Association between baseline fetal hemoglobin levels and incidence of severe vaso-occlusive pain episodes in children with sickle cell anemia

Abstract

Keywords

ASJC Scopus subject areas

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