Association between age and striatal volume Stratified by CAG repeat length in prodromal Huntington disease

Elizabeth H. Aylward, James Mills, Dawei Liu, Peggy Nopoulos, Christopher A Ross, Ronald Pierson, Jane S. Paulsen

Research output: Contribution to journalArticle

Abstract

Background: Longer CAG repeat length is associated with faster clinical progression in Huntington disease, although the effect of higher repeat length on brain atrophy is not well documented. Method: Striatal volumes were obtained from MRI scans of 720 individuals with prodromal Huntington disease. Striatal volume was plotted against age separately for groups with CAG repeat lengths of 38-39, 40, 41, 42, 43, 44, 45, 46, and 47-54. Results: Slopes representing the association between age and striatal volume were significantly steeper as CAG repeat length increased. Discussion: Although cross-sectional, these data suggest that striatal atrophy, like clinical progression, may occur faster with higher CAG repeat lengths.

Original languageEnglish (US)
Article numberecurrents.RRN1235
JournalPLoS Currents
DOIs
StatePublished - 2011

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Corpus Striatum
Huntington Disease
Atrophy
Age Groups
Magnetic Resonance Imaging
Brain

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Association between age and striatal volume Stratified by CAG repeat length in prodromal Huntington disease. / Aylward, Elizabeth H.; Mills, James; Liu, Dawei; Nopoulos, Peggy; Ross, Christopher A; Pierson, Ronald; Paulsen, Jane S.

In: PLoS Currents, 2011.

Research output: Contribution to journalArticle

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AU - Pierson, Ronald

AU - Paulsen, Jane S.

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