TY - JOUR
T1 - Association between age and striatal volume Stratified by CAG repeat length in prodromal Huntington disease
AU - Aylward, Elizabeth
AU - Mills, James
AU - Liu, Dawei
AU - Nopoulos, Peggy
AU - Ross, Christopher A.
AU - Pierson, Ronald
AU - Paulsen, Jane S.
PY - 2011
Y1 - 2011
N2 - Background: Longer CAG repeat length is associated with faster clinical progression in Huntington disease, although the effect of higher repeat length on brain atrophy is not well documented. Method: Striatal volumes were obtained from MRI scans of 720 individuals with prodromal Huntington disease. Striatal volume was plotted against age separately for groups with CAG repeat lengths of 38-39, 40, 41, 42, 43, 44, 45, 46, and 47-54. Results: Slopes representing the association between age and striatal volume were significantly steeper as CAG repeat length increased. Discussion: Although cross-sectional, these data suggest that striatal atrophy, like clinical progression, may occur faster with higher CAG repeat lengths.
AB - Background: Longer CAG repeat length is associated with faster clinical progression in Huntington disease, although the effect of higher repeat length on brain atrophy is not well documented. Method: Striatal volumes were obtained from MRI scans of 720 individuals with prodromal Huntington disease. Striatal volume was plotted against age separately for groups with CAG repeat lengths of 38-39, 40, 41, 42, 43, 44, 45, 46, and 47-54. Results: Slopes representing the association between age and striatal volume were significantly steeper as CAG repeat length increased. Discussion: Although cross-sectional, these data suggest that striatal atrophy, like clinical progression, may occur faster with higher CAG repeat lengths.
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U2 - 10.1371/currents.RRN1235
DO - 10.1371/currents.RRN1235
M3 - Article
C2 - 21593963
AN - SCOPUS:84863708297
SN - 2157-3999
JO - PLoS Currents
JF - PLoS Currents
M1 - ecurrents.RRN1235
ER -