TY - JOUR
T1 - Association between adult height, genetic susceptibility and risk of glioma
AU - Kitahara, Cari M.
AU - Wang, Sophia S.
AU - Melin, Beatrice S.
AU - Wang, Zhaoming
AU - Braganza, Melissa
AU - Inskip, Peter D.
AU - Albanes, Demetrius
AU - Andersson, Ulrika
AU - Beane freeman, Laura E.
AU - Buring, Julie E.
AU - Carreón, Tania
AU - Feychting, Maria
AU - Gapstur, Susan M.
AU - Gaziano, J. Michael
AU - Giles, Graham G.
AU - Hallmans, Goran
AU - Hankinson, Susan E.
AU - Henriksson, Roger
AU - Hsing, Ann W.
AU - Johansen, Christoffer
AU - Linet, Martha S.
AU - Mckean-cowdin, Roberta
AU - Michaud, Dominique S.
AU - Peters, Ulrike
AU - Purdue, Mark P.
AU - Rothman, Nathaniel
AU - Ruder, Avima M.
AU - Sesso, Howard D.
AU - Severi, Gianluca
AU - Shu, Xiao Ou
AU - Stevens, Victoria L.
AU - Visvanathan, Kala
AU - Waters, Martha A.
AU - White, Emily
AU - Wolk, Alicja
AU - Zeleniuch-jacquotte, Anne
AU - Zheng, Wei
AU - Hoover, Robert
AU - Fraumeni, Joseph F.
AU - Chatterjee, Nilanjan
AU - Yeager, Meredith
AU - Chanock, Stephen J.
AU - Hartge, Patricia
AU - Rajaraman, Preetha
N1 - Funding Information:
For PLCO: This research was supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics and by contracts from the Division of Cancer Prevention, NCI, National Institutes of Health (NIH) and Department of Health and Human Services (DHHS). The authors thank Drs Christine Berg and Philip Prorok, Division of Cancer Prevention, NCI, the Screening Center investigators and staff of the PLCO cancer screening trial, Mr Tom Riley and staff, Information Management Services, Inc., Ms Barbara O’Brien and staff, Westat, Inc., Mr Tim Sheehy and staff, DNA Extraction and Staging Laboratory, SAIC-Frederick, Inc. and Ms Jackie King and staff, BioReliance, Inc.
Funding Information:
For MCCS: Infrastructure support for the MCCS recruitment and follow-up is provided by the Cancer Council Victoria, and cohort recruitment was partly funded by VicHealth. This work using the MCCS was supported by the Australian National Health and Medical Research Council (grant numbers 209057, 251533 and 396414).
Funding Information:
For NYUWHS: The NYUWHS is supported by National Cancer Institute grants R01 CA098661 and P30 CA016087 and by Center grant ES000260 from the National Institute of Environmental Health Sciences.
Funding Information:
For VITAL: Grant K05CA154337 is funded by the NCI and the NIH Office of Dietary Supplements (ODS).
Funding Information:
For CLUE: Cancer incidence data were provided by the Maryland Cancer Registry, Center for Cancer Surveillance and Control, Department of Health and Mental Hygiene, 201 W. Preston Street, Room 400, Baltimore, MD 21201, USA; www.fha.state.md.us/ cancer/registry/, 410-767-4055. The authors acknowledge the State of Maryland, the Maryland Cigarette Restitution Fund and the National Program of Cancer Registries of the Centers for Disease Control and Prevention for the funds that support the collection and availability of the cancer registry data. The findings and conclusions of this report are those of the authors and do not necessarily represent the views of the Maryland Cancer Registry.
Funding Information:
For CPS-II Nutrition Cohort: The Cancer Prevention Studies are supported by the American Cancer Society. Efforts of the ACS the study management group to maintain and follow the cohort are acknowledged. ACS investigators also acknowledge the contributions from central cancer registries supported through the Centers for Disease Control and Prevention’s National Program of Cancer Registries and cancer registries supported by the National Cancer Institute’s Surveillance Epidemiology and End Results Program.
Funding Information:
This work was supported in part by the Intramural Research Program of the NCI, National Institutes of Health.
PY - 2012/8
Y1 - 2012/8
N2 - Background: Some, but not all, observational studies have suggested that taller stature is associated with a significant increased risk of glioma. In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated effect modification by genetic susceptibility to the disease. Methods: We standardized and combined individual-level data on 1354 cases and 4734 control subjects from 13 prospective and 2 case-control studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for glioma and glioma sub-types were estimated using logistic regression models stratified by sex and adjusted for birth cohort and study. Pooled ORs were additionally estimated after stratifying the models according to seven recently identified glioma-related genetic variants. Results: Among men, we found a positive association between height and glioma risk (≥190 vs 170-174 cm, pooled OR = 1.70, 95% CI: 1.11-2.61; P-trend = 0.01), which was slightly stronger after restricting to cases with glioblastoma (pooled OR = 1.99, 95% CI: 1.17-3.38; P-trend = 0.02). Among women, these associations were less clear (≥175 vs 160-164 cm, pooled OR for glioma = 1.06, 95% CI: 0.70-1.62; P-trend = 0.22; pooled OR for glioblastoma = 1.36, 95% CI: 0.77-2.39; P-trend = 0.04). In general, we did not observe evidence of effect modification by glioma-related genotypes on the association between height and glioma risk. Conclusion: An association of taller adult stature with glioma, particularly for men and stronger for glioblastoma, should be investigated further to clarify the role of environmental and genetic determinants of height in the etiology of this disease. Published by Oxford University Press on behalf of the International Epidemiological Association 2012.
AB - Background: Some, but not all, observational studies have suggested that taller stature is associated with a significant increased risk of glioma. In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated effect modification by genetic susceptibility to the disease. Methods: We standardized and combined individual-level data on 1354 cases and 4734 control subjects from 13 prospective and 2 case-control studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for glioma and glioma sub-types were estimated using logistic regression models stratified by sex and adjusted for birth cohort and study. Pooled ORs were additionally estimated after stratifying the models according to seven recently identified glioma-related genetic variants. Results: Among men, we found a positive association between height and glioma risk (≥190 vs 170-174 cm, pooled OR = 1.70, 95% CI: 1.11-2.61; P-trend = 0.01), which was slightly stronger after restricting to cases with glioblastoma (pooled OR = 1.99, 95% CI: 1.17-3.38; P-trend = 0.02). Among women, these associations were less clear (≥175 vs 160-164 cm, pooled OR for glioma = 1.06, 95% CI: 0.70-1.62; P-trend = 0.22; pooled OR for glioblastoma = 1.36, 95% CI: 0.77-2.39; P-trend = 0.04). In general, we did not observe evidence of effect modification by glioma-related genotypes on the association between height and glioma risk. Conclusion: An association of taller adult stature with glioma, particularly for men and stronger for glioblastoma, should be investigated further to clarify the role of environmental and genetic determinants of height in the etiology of this disease. Published by Oxford University Press on behalf of the International Epidemiological Association 2012.
KW - Brain cancer
KW - Cancer
KW - Epidemiology
KW - Glioma
KW - Height
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U2 - 10.1093/ije/dys114
DO - 10.1093/ije/dys114
M3 - Article
C2 - 22933650
AN - SCOPUS:84865725722
SN - 0300-5771
VL - 41
SP - 1075
EP - 1085
JO - International journal of epidemiology
JF - International journal of epidemiology
IS - 4
M1 - dys114
ER -