Association between a serotonin transporter promoter polymorphism (5HTTLPR) and personality disorder traits in a community sample

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: The serotonin transporter (SERT) polymorphism (5HTTLPR) has been reported to be associated with several psychiatric conditions. Specific personality disorders could be intermediate factors in the known relationship between 5HTTLPR and psychiatric disorders. This is the first study to test the association between this polymorphism and dimensions of all DSM-IV personality disorders in a community sample. Methods: 374 white participants were assessed by clinical psychologists using the International Personality Disorder Examination (IPDE). Associations between dimensions of each DSM-IV personality disorder and the long (l) and short (s) alleles of the 5HTTLPR were evaluated using non-parametric tests and regression models. Results: The s allele of the 5HTTLPR polymorphism was significantly associated with higher avoidant personality trait scores in the whole sample. Males with the s allele had a significantly lower likelihood of higher obsessive-compulsive personality disorder (OCPD) trait scores, whereas females with the s allele were likely to have higher OCPD personality trait scores. Conclusion: This paper provides preliminary data on the relationship between personality disorders and the 5HTTLPR polymorphism. The relationship of the s allele and avoidant PD is consistent with findings of a nonspecific relationship of this polymorphism to anxiety and depressive disorders. Concerning the unusual sexual dimorphic result with OCPD, several hypotheses are presented. These findings need further replication, including a more detailed study of additional variants in SERT.

Original languageEnglish (US)
Pages (from-to)1153-1159
Number of pages7
JournalJournal of Psychiatric Research
Volume45
Issue number9
DOIs
StatePublished - Sep 2011

Keywords

  • Avoidant personality
  • Obsessive compulsive personality
  • Personality disorders
  • Polymorphism
  • Serotonin transporter gene
  • Sex differences

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Association between a serotonin transporter promoter polymorphism (5HTTLPR) and personality disorder traits in a community sample'. Together they form a unique fingerprint.

Cite this