Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder

Daniel J. Müller, Thomas G. Schulze, Esther Jahnes, Sven Cichon, Harald Krauss, Kristina Kesper, Tilo Held, Wolfgang Maier, Peter Propping, Markus M. Nöthen, Marcella Rietschel

Research output: Contribution to journalArticle

Abstract

In the past decade, several chromosomal regions have been analyzed for linkage with bipolar affective disorder (BPAD). There have been conflicting results regarding the involvement of X-chromosomal regions in harboring susceptibility genes for BPAD. Recently, a new candidate gene (SYBL1) for BPAD has been described on Xq28. SYBL1, which maps to the Xq pseudoautosomal region (PAR), encodes a member of the synaptobrevin family of proteins involved in synaptic vesicle docking, exocytosis, and membrane transport. A subsequent case-control association study, including 110 US-American patients with BPAD and 119 unrelated controls, investigated a potential etiological role of a novel polymorphism (G→C transversion) in a regulatory region of the SYBL1 gene. In this analysis, the C allele showed a statistical trend to be more frequent in males with BPAD than in respective controls (P=0.06). This finding prompted us to verify whether a similar effect was also present in a larger German sample of 164 unrelated patients with BPAD (148 patients with BP I disorder, 16 patients with BP II disorder) and 267 controls. We observed a significantly increased frequency of genotypes homozygous for the C allele in females with BPAD in comparison with controls (P=0.017). Thus, our data strengthen the role of the SYBL1 gene as a candidate gene for BPAD.

Original languageEnglish (US)
Pages (from-to)74-78
Number of pages5
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume114
Issue number1
DOIs
StatePublished - Jan 8 2002
Externally publishedYes

Fingerprint

X-Linked Genes
Mood Disorders
Bipolar Disorder
Genes
Alleles
R-SNARE Proteins
Synaptic Vesicles
Nucleic Acid Regulatory Sequences
Exocytosis
Case-Control Studies
Genotype
Membranes

Keywords

  • Association study
  • Female gender
  • Manic depressive illness
  • SNARE complex proteins
  • X-chromosome

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder. / Müller, Daniel J.; Schulze, Thomas G.; Jahnes, Esther; Cichon, Sven; Krauss, Harald; Kesper, Kristina; Held, Tilo; Maier, Wolfgang; Propping, Peter; Nöthen, Markus M.; Rietschel, Marcella.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 114, No. 1, 08.01.2002, p. 74-78.

Research output: Contribution to journalArticle

Müller, DJ, Schulze, TG, Jahnes, E, Cichon, S, Krauss, H, Kesper, K, Held, T, Maier, W, Propping, P, Nöthen, MM & Rietschel, M 2002, 'Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 114, no. 1, pp. 74-78. https://doi.org/10.1002/ajmg.10115
Müller, Daniel J. ; Schulze, Thomas G. ; Jahnes, Esther ; Cichon, Sven ; Krauss, Harald ; Kesper, Kristina ; Held, Tilo ; Maier, Wolfgang ; Propping, Peter ; Nöthen, Markus M. ; Rietschel, Marcella. / Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 2002 ; Vol. 114, No. 1. pp. 74-78.
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