Assisted hatching in the treatment of poor prognosis in vitro fertilization candidates

W. B. Schoolcraft, T. Schlenker, M. Gee, G. S. Jones, H. W. Jones

Research output: Contribution to journalArticlepeer-review


Objective: To access the effect of augmenting IVF with assisted hatching in the treatment of poor-prognosis patients. Design: Thirty-three poor- prognosis IVF patients were treated with assisted hatching and were compared with 43 control subjects without assisted hatching. Setting: Center for Reproductive Medicine, Swedish Medical Center, Englewood, Colorado. Participants: Seventy-six women undergoing IVF with a poor prognosis for pregnancy. Poor prognosis was defined as Elevated day 3 FSH level; age ≥ 39 years; and multiple prior IVF failures. Main Outcome Measures: Pregnancy and implantation rates per embryo. Results: The incidence of ongoing pregnancy in the assisted hatching group was 64% compared with 19% in the control group. Implantation rate per embryo transferred was 33% in the assisted hatching group versus 6.5% in the control group. Conclusions: These results demonstrate that assisted hatching, when applied to poor-prognosis patients, improves embryonic implantation and pregnancy rates.

Original languageEnglish (US)
Pages (from-to)551-554
Number of pages4
JournalFertility and sterility
Issue number3
StatePublished - 1994


  • Assisted hatching
  • elevated follicle-stimulating hormones
  • embryonic implantation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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