Assiociations of patella lead with polymorphisms in the vitamin D receptor, δ-aminolevulinic acid dehydratase and endothelial nitric oxide synthase genes

Keson Theppeang, Brian Schwartz, Byung Kook Lee, Mark E. Lustberg, Ellen K. Silbergeld, Karl T. Kelsey, Patrick J. Parsons, Andrew C. Todd

Research output: Contribution to journalArticlepeer-review

Abstract

A cross-sectional analysis was performed to evaluate associations of polymorphisms in the vitamin D receptor (VDR), δ-aminolevulinic acid dehydratase (ALAD), and endothelial nitric oxide synthase (eNOS) genes with patella lead concentrations in 652 lead workers in the Republic of Korea. There was a wide range of patella lead (from below detection limit to 946 μg Pb/g bone mineral), with a mean (standard deviation) of 75.2 (101.0). There were no associations of ALAD or eNOS genotypes with patella lead, but workers with the VDR B allele had significantly (P value <0.05) higher patella lead (on average, 25% or approximately 6.6 μg Pb/g bone mineral) than lead workers with the VDR bb genotype. There was evidence that the relation between age and patella lead was modified by both the VDR and eNOS genotypes.

Original languageEnglish (US)
Pages (from-to)528-537
Number of pages10
JournalJournal of occupational and environmental medicine
Volume46
Issue number6
DOIs
StatePublished - Jun 1 2004

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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