Assignment of the hypoxia-inducible factor 1α gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q

G. L. Semenza, E. A. Rue, N. V. Iyer, M. G. Pang, W. G. Kearns

Research output: Contribution to journalArticle

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor that mediates homeostatic responses to hypoxia. HIF-1 is a heterodimer consisting of HIF-1α, which is encoded by the HIF1A gene, complexed with HIF-1β, which is encoded by the ARNT gene. In this paper we report the assignment of Hif1a and HIF1A to mouse chromosome 12 and human chromosome 14, respectively. HIF1A was assigned to human chromosome 14q21- q24 by analysis of somatic cell hybrids and by fluorescence in situ hybridization. Hipo was localized by interspecific backcross analysis within a region of mouse chromosome 12 encompassing >30 cM that demonstrates conservation of synteny with a region of human chromosome 14 extending from PAX9 at 14q12-q13 to IGHC at 14q32.33.

Original languageEnglish (US)
Pages (from-to)437-439
Number of pages3
JournalGenomics
Volume34
Issue number3
DOIs
StatePublished - Jun 15 1996

ASJC Scopus subject areas

  • Genetics

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