Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization

J. T. Elder; A. Åström; U. Pettersson; J. J. Voorhees; J. M. Trent

doi:10.1007/BF00219171

Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization

J. T. Elder, A. Åström, U. Pettersson, J. J. Voorhees, J. M. Trent

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Abstract

Two highly conserved forms of cellular retinoic acid binding protein (CRABP-I and CRABP-II) have been described, and one, CRABP-II, is highly expressed in human skin. We have utilized a 10-kb fragment containing the human CRABP-II (hCRABP-II) gene (isolated from a human genomic library) to localize hCRABP-II to human chromosome 1 band q21 by fluorescence in situ hybridization. Localization to 1q was confirmed by hybridization of a hCRABP-II cDNA clone against a human-mouse hybrid cell line containing a t(1;6)(q21;q13) translocation chromosome. The hCRABP-II gene is therefore localized to a band known to contain several other genes that are expressed in the context of epidermal differentiation, including profilaggrin, loricrin, involucrin, and calcyclin.

Original language	English (US)
Pages (from-to)	487-490
Number of pages	4
Journal	Human genetics
Volume	89
Issue number	5
DOIs	https://doi.org/10.1007/BF00219171
State	Published - Jul 1992
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization",

abstract = "Two highly conserved forms of cellular retinoic acid binding protein (CRABP-I and CRABP-II) have been described, and one, CRABP-II, is highly expressed in human skin. We have utilized a 10-kb fragment containing the human CRABP-II (hCRABP-II) gene (isolated from a human genomic library) to localize hCRABP-II to human chromosome 1 band q21 by fluorescence in situ hybridization. Localization to 1q was confirmed by hybridization of a hCRABP-II cDNA clone against a human-mouse hybrid cell line containing a t(1;6)(q21;q13) translocation chromosome. The hCRABP-II gene is therefore localized to a band known to contain several other genes that are expressed in the context of epidermal differentiation, including profilaggrin, loricrin, involucrin, and calcyclin.",

author = "Elder, {J. T.} and A. {\AA}str{\"o}m and U. Pettersson and Voorhees, {J. J.} and Trent, {J. M.}",

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T1 - Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization

AU - Elder, J. T.

AU - Åström, A.

AU - Pettersson, U.

AU - Voorhees, J. J.

AU - Trent, J. M.

PY - 1992/7

Y1 - 1992/7

N2 - Two highly conserved forms of cellular retinoic acid binding protein (CRABP-I and CRABP-II) have been described, and one, CRABP-II, is highly expressed in human skin. We have utilized a 10-kb fragment containing the human CRABP-II (hCRABP-II) gene (isolated from a human genomic library) to localize hCRABP-II to human chromosome 1 band q21 by fluorescence in situ hybridization. Localization to 1q was confirmed by hybridization of a hCRABP-II cDNA clone against a human-mouse hybrid cell line containing a t(1;6)(q21;q13) translocation chromosome. The hCRABP-II gene is therefore localized to a band known to contain several other genes that are expressed in the context of epidermal differentiation, including profilaggrin, loricrin, involucrin, and calcyclin.

AB - Two highly conserved forms of cellular retinoic acid binding protein (CRABP-I and CRABP-II) have been described, and one, CRABP-II, is highly expressed in human skin. We have utilized a 10-kb fragment containing the human CRABP-II (hCRABP-II) gene (isolated from a human genomic library) to localize hCRABP-II to human chromosome 1 band q21 by fluorescence in situ hybridization. Localization to 1q was confirmed by hybridization of a hCRABP-II cDNA clone against a human-mouse hybrid cell line containing a t(1;6)(q21;q13) translocation chromosome. The hCRABP-II gene is therefore localized to a band known to contain several other genes that are expressed in the context of epidermal differentiation, including profilaggrin, loricrin, involucrin, and calcyclin.

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Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization

Abstract

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