Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization

J. T. Elder, A. Åström, U. Pettersson, J. J. Voorhees, J. M. Trent

Research output: Contribution to journalArticlepeer-review

Abstract

Two highly conserved forms of cellular retinoic acid binding protein (CRABP-I and CRABP-II) have been described, and one, CRABP-II, is highly expressed in human skin. We have utilized a 10-kb fragment containing the human CRABP-II (hCRABP-II) gene (isolated from a human genomic library) to localize hCRABP-II to human chromosome 1 band q21 by fluorescence in situ hybridization. Localization to 1q was confirmed by hybridization of a hCRABP-II cDNA clone against a human-mouse hybrid cell line containing a t(1;6)(q21;q13) translocation chromosome. The hCRABP-II gene is therefore localized to a band known to contain several other genes that are expressed in the context of epidermal differentiation, including profilaggrin, loricrin, involucrin, and calcyclin.

Original languageEnglish (US)
Pages (from-to)487-490
Number of pages4
JournalHuman genetics
Volume89
Issue number5
DOIs
StatePublished - Jul 1992

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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