Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization

J. T. Elder, A. Åström, U. Pettersson, J. J. Voorhees, J. M. Trent

Research output: Contribution to journalArticle

Abstract

Two highly conserved forms of cellular retinoic acid binding protein (CRABP-I and CRABP-II) have been described, and one, CRABP-II, is highly expressed in human skin. We have utilized a 10-kb fragment containing the human CRABP-II (hCRABP-II) gene (isolated from a human genomic library) to localize hCRABP-II to human chromosome 1 band q21 by fluorescence in situ hybridization. Localization to 1q was confirmed by hybridization of a hCRABP-II cDNA clone against a human-mouse hybrid cell line containing a t(1;6)(q21;q13) translocation chromosome. The hCRABP-II gene is therefore localized to a band known to contain several other genes that are expressed in the context of epidermal differentiation, including profilaggrin, loricrin, involucrin, and calcyclin.

Original languageEnglish (US)
Pages (from-to)487-490
Number of pages4
JournalHuman Genetics
Volume89
Issue number5
DOIs
StatePublished - Jul 1992
Externally publishedYes

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In Situ Hybridization
Chromosomes
Genes
Genomic Library
Hybrid Cells
Chromosomes, Human, Pair 1
Human Chromosomes
cellular retinoic acid binding protein II
Fluorescence In Situ Hybridization
Complementary DNA
Clone Cells
Cell Line
Skin

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Elder, J. T., Åström, A., Pettersson, U., Voorhees, J. J., & Trent, J. M. (1992). Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization. Human Genetics, 89(5), 487-490. https://doi.org/10.1007/BF00219171

Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization. / Elder, J. T.; Åström, A.; Pettersson, U.; Voorhees, J. J.; Trent, J. M.

In: Human Genetics, Vol. 89, No. 5, 07.1992, p. 487-490.

Research output: Contribution to journalArticle

Elder, JT, Åström, A, Pettersson, U, Voorhees, JJ & Trent, JM 1992, 'Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization', Human Genetics, vol. 89, no. 5, pp. 487-490. https://doi.org/10.1007/BF00219171
Elder, J. T. ; Åström, A. ; Pettersson, U. ; Voorhees, J. J. ; Trent, J. M. / Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization. In: Human Genetics. 1992 ; Vol. 89, No. 5. pp. 487-490.
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