Assignment of the ζ-Crystallin Gene (CRYZ) to Human Chromosome 1p22-p31 and Identification of Restriction Fragment Length Polymorphisms

C. Heinzmann, T. L. Kojis, P. Gonzalez, P. V. Rao, J. S. Zigler, M. H. Polymeropoulos, I. Klisak, R. S. Sparkes, T. Mohandas, J. B. Bateman

Research output: Contribution to journalArticle

Abstract

ζ-Crystallin is a lens protein that has been associated with autosomal dominant congenital cataracts in guinea pigs and thus is a candidate for human congenital cataracts. We have assigned the ζ-crystallin gene (CRYZ) to human chromosome 1 using a Southern panel of 17 human-mouse somatic cell hybrids and regionally localized it to 1p22-p31 by fluorescence in situ hybridization. Five restriction fragment length polymorphisms were identified by analyzing the DNA from 10 unrelated, unaffected individuals. Our results will permit evaluation of its role in human cataractogenesis.

Original languageEnglish (US)
Pages (from-to)403-407
Number of pages5
JournalGenomics
Volume23
Issue number2
DOIs
StatePublished - Sep 15 1994
Externally publishedYes

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Crystallins
Human Chromosomes
Restriction Fragment Length Polymorphisms
Genes
Hybrid Cells
Chromosomes, Human, Pair 1
Fluorescence In Situ Hybridization
Cataract
Guinea Pigs
DNA

ASJC Scopus subject areas

  • Genetics

Cite this

Heinzmann, C., Kojis, T. L., Gonzalez, P., Rao, P. V., Zigler, J. S., Polymeropoulos, M. H., ... Bateman, J. B. (1994). Assignment of the ζ-Crystallin Gene (CRYZ) to Human Chromosome 1p22-p31 and Identification of Restriction Fragment Length Polymorphisms. Genomics, 23(2), 403-407. https://doi.org/10.1006/geno.1994.1516

Assignment of the ζ-Crystallin Gene (CRYZ) to Human Chromosome 1p22-p31 and Identification of Restriction Fragment Length Polymorphisms. / Heinzmann, C.; Kojis, T. L.; Gonzalez, P.; Rao, P. V.; Zigler, J. S.; Polymeropoulos, M. H.; Klisak, I.; Sparkes, R. S.; Mohandas, T.; Bateman, J. B.

In: Genomics, Vol. 23, No. 2, 15.09.1994, p. 403-407.

Research output: Contribution to journalArticle

Heinzmann, C, Kojis, TL, Gonzalez, P, Rao, PV, Zigler, JS, Polymeropoulos, MH, Klisak, I, Sparkes, RS, Mohandas, T & Bateman, JB 1994, 'Assignment of the ζ-Crystallin Gene (CRYZ) to Human Chromosome 1p22-p31 and Identification of Restriction Fragment Length Polymorphisms', Genomics, vol. 23, no. 2, pp. 403-407. https://doi.org/10.1006/geno.1994.1516
Heinzmann, C. ; Kojis, T. L. ; Gonzalez, P. ; Rao, P. V. ; Zigler, J. S. ; Polymeropoulos, M. H. ; Klisak, I. ; Sparkes, R. S. ; Mohandas, T. ; Bateman, J. B. / Assignment of the ζ-Crystallin Gene (CRYZ) to Human Chromosome 1p22-p31 and Identification of Restriction Fragment Length Polymorphisms. In: Genomics. 1994 ; Vol. 23, No. 2. pp. 403-407.
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