Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5

D. Sieburth; E. W. Jabs; J. A. Warrington; X. Li; J. Lasota; S. LaForgia; K. Kelleher; K. Huebner; J. J. Wasmuth; S. F. Wolf

doi:10.1016/S0888-7543(05)80283-6

Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5

D. Sieburth, E. W. Jabs, J. A. Warrington, X. Li, J. Lasota, S. LaForgia, K. Kelleher, K. Huebner, J. J. Wasmuth, S. F. Wolf

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

Abstract

IL12 (formerly NKSF or CLMF) is a unique cytokine composed of two unrelated disulfide-linked subunits. The larger 40-kDa subunit (p40) is a member of the cytokine receptor family, and the smaller 35-kDa subunit (p35) is related to IL6 and GCSF. The chromosomal localization of these two subunits was determined by PCR analysis of DNA from rodent-human hybrids. More refined mapping was obtained by PCR analysis of hybrids containing translocation chromosomes and for p40, by analysis of radiation hybrids. The subunits map to different chromosomes: p40 (IL12B) to 5q31-q33 and p35 (IL12A) to 3p12-3q13.2.

Original language	English (US)
Pages (from-to)	59-62
Number of pages	4
Journal	Genomics
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/S0888-7543(05)80283-6
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1016/S0888-7543(05)80283-6

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title = "Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5",

abstract = "IL12 (formerly NKSF or CLMF) is a unique cytokine composed of two unrelated disulfide-linked subunits. The larger 40-kDa subunit (p40) is a member of the cytokine receptor family, and the smaller 35-kDa subunit (p35) is related to IL6 and GCSF. The chromosomal localization of these two subunits was determined by PCR analysis of DNA from rodent-human hybrids. More refined mapping was obtained by PCR analysis of hybrids containing translocation chromosomes and for p40, by analysis of radiation hybrids. The subunits map to different chromosomes: p40 (IL12B) to 5q31-q33 and p35 (IL12A) to 3p12-3q13.2.",

author = "D. Sieburth and Jabs, {E. W.} and Warrington, {J. A.} and X. Li and J. Lasota and S. LaForgia and K. Kelleher and K. Huebner and Wasmuth, {J. J.} and Wolf, {S. F.}",

year = "1992",

doi = "10.1016/S0888-7543(05)80283-6",

language = "English (US)",

volume = "14",

pages = "59--62",

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publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5

AU - Sieburth, D.

AU - Jabs, E. W.

AU - Warrington, J. A.

AU - Li, X.

AU - Lasota, J.

AU - LaForgia, S.

AU - Kelleher, K.

AU - Huebner, K.

AU - Wasmuth, J. J.

AU - Wolf, S. F.

PY - 1992

Y1 - 1992

N2 - IL12 (formerly NKSF or CLMF) is a unique cytokine composed of two unrelated disulfide-linked subunits. The larger 40-kDa subunit (p40) is a member of the cytokine receptor family, and the smaller 35-kDa subunit (p35) is related to IL6 and GCSF. The chromosomal localization of these two subunits was determined by PCR analysis of DNA from rodent-human hybrids. More refined mapping was obtained by PCR analysis of hybrids containing translocation chromosomes and for p40, by analysis of radiation hybrids. The subunits map to different chromosomes: p40 (IL12B) to 5q31-q33 and p35 (IL12A) to 3p12-3q13.2.

AB - IL12 (formerly NKSF or CLMF) is a unique cytokine composed of two unrelated disulfide-linked subunits. The larger 40-kDa subunit (p40) is a member of the cytokine receptor family, and the smaller 35-kDa subunit (p35) is related to IL6 and GCSF. The chromosomal localization of these two subunits was determined by PCR analysis of DNA from rodent-human hybrids. More refined mapping was obtained by PCR analysis of hybrids containing translocation chromosomes and for p40, by analysis of radiation hybrids. The subunits map to different chromosomes: p40 (IL12B) to 5q31-q33 and p35 (IL12A) to 3p12-3q13.2.

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EP - 62

JO - Genomics

JF - Genomics

IS - 1

ER -

Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5

Abstract

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