Assessment of vitamin A status of preschool children in Indonesia using plasma retinol-binding protein

Richard David Semba, Y. Yuniar, M. V. Gamble, G. Natadisastra, Muhilal

Research output: Contribution to journalArticle

Abstract

Although plasma retinol-binding protein (RBP) has been proposed as an indicator of vitamin A status of populations in less technologically developed settings, potential factors which could influence this indicator include inflammation and protein energy status. Plasma RBP, retinol, α1-acid glycoprotein (AGP), C-reactive protein (CRP), and albumin were measured in a study of 236 preschool children in Bandung, Indonesia. Spearman correlation coefficient between plasma RBP and retinol concentrations was 0.55 (p <0.0001). By linear regression, 0.70 μmol/l retinol was equivalent to 0.69 μmol/l RBP. With these cut-off points for defining vitamin A deficiency and plasma retinol as the standard for comparison, RBP had a sensitivity and specificity of 75.0 per cent and 63.2 per cent, respectively. The correlation between RBP and retinol was not affected by plasma AGP, CRP, or albumin concentration. Measurement of plasma RBP by radial immunodiffusion is simple and inexpensive, and this test can be used as a simple surrogate measure for vitamin A concentrations in large field studies.

Original languageEnglish (US)
Pages (from-to)84-87
Number of pages4
JournalJournal of Tropical Pediatrics
Volume48
Issue number2
DOIs
StatePublished - 2002

Fingerprint

Plasma Retinol-Binding Proteins
Indonesia
Preschool Children
Vitamin A
Retinol-Binding Proteins
C-Reactive Protein
Albumins
Cellular Retinol-Binding Proteins
Vitamin A Deficiency
Acids
Immunodiffusion
Linear Models
Inflammation
Sensitivity and Specificity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Assessment of vitamin A status of preschool children in Indonesia using plasma retinol-binding protein. / Semba, Richard David; Yuniar, Y.; Gamble, M. V.; Natadisastra, G.; Muhilal.

In: Journal of Tropical Pediatrics, Vol. 48, No. 2, 2002, p. 84-87.

Research output: Contribution to journalArticle

Semba, Richard David ; Yuniar, Y. ; Gamble, M. V. ; Natadisastra, G. ; Muhilal. / Assessment of vitamin A status of preschool children in Indonesia using plasma retinol-binding protein. In: Journal of Tropical Pediatrics. 2002 ; Vol. 48, No. 2. pp. 84-87.
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