Assessment of visual function in patients with gyrate atrophy who are considered candidates for gene replacement

Rafael C. Caruso, Robert B. Nussenblatt, Karl G. Csaky, David Valle, Muriel I. Kaiser-Kupfer

Research output: Contribution to journalArticle


Objective: To assess the course of change of visual function outcome variables in 5 patients with gyrate atrophy before a gene replacement therapy clinical trial. Methods: The outcome variables selected were visual field sensitivity and electroretinogram amplitude. The course of change of these outcome variables was determined by calculation of their half-lives. Results: In the 4 to 6 years during which each patient was followed up for this study, median visual field half-lives were 17.0 years (static perimetry) and 11.4 years (kinetic perimetry). Median electroretinogram half-lives were 16.0 years (maximal response) and 10.7 years (flicker response). Conclusions: The course of the decline of visual function outcome variables is frequently slow. Thus, a long-term clinical trial would be required to assess the efficacy of the intervention in the preservation of visual function.

Original languageEnglish (US)
Pages (from-to)667-669
Number of pages3
JournalArchives of ophthalmology
Issue number5
StatePublished - Jan 1 2001


ASJC Scopus subject areas

  • Ophthalmology

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