Abstract
Objective: To assess the course of change of visual function outcome variables in 5 patients with gyrate atrophy before a gene replacement therapy clinical trial. Methods: The outcome variables selected were visual field sensitivity and electroretinogram amplitude. The course of change of these outcome variables was determined by calculation of their half-lives. Results: In the 4 to 6 years during which each patient was followed up for this study, median visual field half-lives were 17.0 years (static perimetry) and 11.4 years (kinetic perimetry). Median electroretinogram half-lives were 16.0 years (maximal response) and 10.7 years (flicker response). Conclusions: The course of the decline of visual function outcome variables is frequently slow. Thus, a long-term clinical trial would be required to assess the efficacy of the intervention in the preservation of visual function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 667-669 |
| Number of pages | 3 |
| Journal | Archives of Ophthalmology |
| Volume | 119 |
| Issue number | 5 |
| State | Published - 2001 |
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ASJC Scopus subject areas
- Ophthalmology
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Assessment of visual function in patients with gyrate atrophy who are considered candidates for gene replacement. / Caruso, Rafael C.; Nussenblatt, Robert B.; Csaky, Karl G.; Valle, David; Kaiser-Kupfer, Muriel I.
In: Archives of Ophthalmology, Vol. 119, No. 5, 2001, p. 667-669.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessment of visual function in patients with gyrate atrophy who are considered candidates for gene replacement
AU - Caruso, Rafael C.
AU - Nussenblatt, Robert B.
AU - Csaky, Karl G.
AU - Valle, David
AU - Kaiser-Kupfer, Muriel I.
PY - 2001
Y1 - 2001
N2 - Objective: To assess the course of change of visual function outcome variables in 5 patients with gyrate atrophy before a gene replacement therapy clinical trial. Methods: The outcome variables selected were visual field sensitivity and electroretinogram amplitude. The course of change of these outcome variables was determined by calculation of their half-lives. Results: In the 4 to 6 years during which each patient was followed up for this study, median visual field half-lives were 17.0 years (static perimetry) and 11.4 years (kinetic perimetry). Median electroretinogram half-lives were 16.0 years (maximal response) and 10.7 years (flicker response). Conclusions: The course of the decline of visual function outcome variables is frequently slow. Thus, a long-term clinical trial would be required to assess the efficacy of the intervention in the preservation of visual function.
AB - Objective: To assess the course of change of visual function outcome variables in 5 patients with gyrate atrophy before a gene replacement therapy clinical trial. Methods: The outcome variables selected were visual field sensitivity and electroretinogram amplitude. The course of change of these outcome variables was determined by calculation of their half-lives. Results: In the 4 to 6 years during which each patient was followed up for this study, median visual field half-lives were 17.0 years (static perimetry) and 11.4 years (kinetic perimetry). Median electroretinogram half-lives were 16.0 years (maximal response) and 10.7 years (flicker response). Conclusions: The course of the decline of visual function outcome variables is frequently slow. Thus, a long-term clinical trial would be required to assess the efficacy of the intervention in the preservation of visual function.
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UR - http://www.scopus.com/inward/citedby.url?scp=0035016875&partnerID=8YFLogxK
M3 - Article
C2 - 11346393
AN - SCOPUS:0035016875
VL - 119
SP - 667
EP - 669
JO - JAMA Ophthalmology
JF - JAMA Ophthalmology
SN - 2168-6165
IS - 5
ER -